Could Weight Loss During Clozapine Therapy be an Indicator of Poor Response?: A Case Report

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dc.authoridKök Kendirlioğlu, Burcu/0000-0003-0632-1617en_US
dc.contributor.authorKök Kendirlioğlu, Burcu
dc.contributor.authorHariri, Aytul Gursu
dc.date.accessioned2024-07-12T21:37:42Z
dc.date.available2024-07-12T21:37:42Z
dc.date.issued2021en_US
dc.department[Belirlenecek]en_US
dc.description.abstractEven though effectiveness of clozapine on treatment resistant schizophrenia has been repeatedly demonstrated, it is also associated with many adverse effects including weight gain. Curiously, significant weight loss may occur in some patients. In this case report we discussed whether the observed weight loss could be a negative prognostic factor. The 56 year-old male patient, followed up with the diagnosis of schizophrenia for 20 years, had persistent positive and negative symptoms despite concurrent use of different antiypsychotics. He was diagnosed with treatment-resistant schizophrenia and started on clozapine with dose titration to 500 mg/day over 3 months. He was observed to have lost 17.6% of his initial body weight after 7 months of therapy. The Positive and Negative Syndrome Scale (PANSS) score of the patient did not change significantly. There are a few case reports in the literature on weight loss during clozapine therapy. Some proposed that the weight loss could be a sign of weak response to treatment which is based on the observation that the clinical response might be poor when there is a weight loss and no change in blood triglyceride levels is observed with the treatment. There is a need for more case-control and preclinical studies to explain the mechanisms underlying weight loss and weak response to clozapine therapy in schizophrenia.en_US
dc.identifier.doi10.5080/u25185
dc.identifier.endpage141en_US
dc.identifier.issn1300-2163
dc.identifier.issue2en_US
dc.identifier.pmid34392510en_US
dc.identifier.startpage137en_US
dc.identifier.trdizinid515002en_US
dc.identifier.urihttps://doi.org/10.5080/u25185
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/515002
dc.identifier.urihttps://hdl.handle.net/20.500.12415/6889
dc.identifier.volume32en_US
dc.identifier.wosWOS:000732788700001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTurkiye Sinir Ve Ruh Sagligi Dernegien_US
dc.relation.ispartofTurk Psikiyatri Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY04231
dc.subjectClozapineen_US
dc.subjectSchizophreniaen_US
dc.subjectWeight Lossen_US
dc.subjectPoor Responseen_US
dc.subjectTriglycerideen_US
dc.titleCould Weight Loss During Clozapine Therapy be an Indicator of Poor Response?: A Case Reporten_US
dc.typeArticle
dspace.entity.typePublication

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