Effect of uncomplicated obesity on QT interval in young men
Küçük Resim Yok
Tarih
2010
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Polish Society of Internal Medicine
Erişim Hakkı
Attribution-NonCommercial-ShareAlike 3.0 United States
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess
Özet
QT prolongation and obesity are associated with ventricular arrhythmia and sudden cardiac death. The relationship between uncomplicated obesity and QT interval prolongation is not clear. OBJECTIVES: The aim of the study was to investigate the effects of uncomplicated obesity on QT interval in young men. PATIENTS AND METHODS: A total of 122 men, including 59 obese patients and 63 controls, were recruited into the study. Patients with hypertension, diabetes mellitus, and ischemic heart disease were ineligible. Body mass index (BMI) of all patients was calculated. QT interval was measured from the precordial lead – V5, and corrected QT (QTC) was calculated using the Bazett’s formula. RESULTS: Mean age, BMI, and waist circumference (WC) of obese patients and controls were as follows: 22.0 ±3.0 years, 36.2 ±2.2 kg/m², and 114 ±8.1 cm; 22.6 ±2.9 years, 24.7 ±2.5 kg/m², and 81.6 ±7.5 cm, respectively. There was a statistically significant difference between the obese and control groups with regard to BMI and WC (P <0.001). Furthermore, statistically significant differences were observed between the 2 groups in terms of QTC (407.9 ±17.1 ms vs. 397.7 ±14.0 ms, respectively, P <0.001), systolic (126.9 ±8.2 mmHg vs. 114.2 ±11.1 mmHg, respectively, P <0.001) and diastolic blood pressure (78.3 ±4.5 mmHg vs. 66.9 ±10 mmHg, respectively, P <0.001). There was a positive correlation between QTC interval and both WC (r = 0.357, P <0.001) and BMI (r = 0.424, P <0.001). There was no association between QTC and blood pressure. CONCLUSIONS: Uncomplicated obesity in young men is associated with QT interval prolongation. Weight gain may inversely affect cardiac repolarization in uncomplicated obesity.
Açıklama
Anahtar Kelimeler
corrected QT, prolonged QT interval, uncomplicated obesity
Kaynak
Polish Archives of Internal Medicine
WoS Q Değeri
Scopus Q Değeri
Q3
Cilt
120
Sayı
6
Künye
Arslan, E., Yığıner, O., Yavaşoğlu, I., Özçelik, F., Kardeşoğlu, E. ve Nalbant, S. (2010). Effect of uncomplicated obesity on QT interval in young men. Polish Archives of Internal Medicine, Polish Society of Internal Medicine. 120(6), s. 209-213.
