The histology and the proapoptotic control in the ipsilateral and the contralateral testes following unilateral vasectomy

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dc.authorid0000-0001-5337-5226en_US
dc.authorid0000-0003-0395-1154en_US
dc.contributor.authorHazar, Aydin Ismet
dc.contributor.authorCakiroglu, Basri
dc.contributor.authorSakalli, Ertan
dc.contributor.authorBalci, Mustafa Bahadir Can
dc.contributor.authorEyyupoglu, Erkan
dc.contributor.authorTas, Tuncay
dc.contributor.authorSinanoglu, Orhun
dc.contributor.authorTuzlali, Pinar
dc.contributor.authorCilesiz, Nusret Can
dc.date.accessioned2024-07-12T21:45:08Z
dc.date.available2024-07-12T21:45:08Z
dc.date.issued2015en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractObjective: The aim of this study was to enlighten both the testicular histology and the genetic aspects of the apoptotic process. Thus an experimental study was designed with a model of unilateral vasectomy. Methods: Twenty-two adult male rats were used and 4 main groups were formed. The first (A), the second (B), the third (C), and the fourth group (D) consisted of 4, 4, 4 and 10 rats respectively. Rats in group A had sham operation while rats in other groups (B, C, D) underwent left vasectomy operation including binding of ductus deferens with a 3/0 silk and cutting a minimum of 1 cm part while preserving the vascular structure under 9x magnification. Rats undergoing unilateral vasectomy were sacrificed at the 1st, 2nd and 8th weeks and their testicular structure and proapoptotic gene proteins were compared with that of the control group undergoing sham operation. Results: We found that vasectomy gradually caused destruction and both ipsilateral and contralateral testicles were affected showing initial apoptosis. Conclusion: The procedure causes destruction in the testicular structure by causing bilateral intratubular germ cell necrosis, unilateral obstruction, increase in the tubular pressure and processes that are aggravated by some probable autoimmune reactions.en_US
dc.description.sponsorshipPathology Laboratory, Taksim Training and Research Hospitalen_US
dc.description.sponsorshipWe thank Pathology Laboratory, Taksim Training and Research Hospital for laboratory facilities, technical assistance and financial aid.en_US
dc.identifier.doi10.4081/aiua.2015.3.198
dc.identifier.endpage203en_US
dc.identifier.issn1124-3562
dc.identifier.issn2282-4197
dc.identifier.issue3en_US
dc.identifier.pmid26428640en_US
dc.identifier.scopus2-s2.0-84953853297en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage198en_US
dc.identifier.urihttps://dx.doi.org/10.4081/aiua.2015.3.198
dc.identifier.urihttps://hdl.handle.net/20.500.12415/7800
dc.identifier.volume87en_US
dc.identifier.wosWOS:000440260800004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherPAGEPRESS PUBLen_US
dc.relation.ispartofARCHIVIO ITALIANO DI UROLOGIA E ANDROLOGIAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY00327
dc.subjectTestisen_US
dc.subjectSpermatogenesisen_US
dc.subjectVasectomyen_US
dc.subjectApoptosisen_US
dc.subjectBCL-2 proteinen_US
dc.titleThe histology and the proapoptotic control in the ipsilateral and the contralateral testes following unilateral vasectomyen_US
dc.typeArticle
dspace.entity.typePublication

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