Comparison of the Effects of Local and Systemic Dexamethasone on the Rat Traumatic Sciatic Nerve Model

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dc.contributor.authorSuslu, Husnu
dc.contributor.authorAltun, Murat
dc.contributor.authorErdivanli, Basar
dc.contributor.authorSuslu, Hikmet Turan
dc.date.accessioned2024-07-12T21:56:40Z
dc.date.available2024-07-12T21:56:40Z
dc.date.issued2013en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractAIM: The aim of the study was to evaluate the effect of peroperatively locally administered dexamethasone on nerve recovery after induced nerve crush injury. MATERIAL and METHODS: 4 groups of 8 animals were formed. The sciatic nerves of 32 rats were exposed at midthigh level and those of 24 rats were crushed for 30 seconds with a pair of jeweler's forceps. RESULTS: Sciatic functional index (SFI) measurements of all the animals included at days 7, 14, 21 and 28 was statistically significant (p<0.05). Pinch tests that were done on the first 13 days gave negative results in all the groups. There was a difference between the test results of Group II and those of Group III and IV at days 14, 21 and 28. When the duration of the experiment was taken as a whole, no difference was observed between the test results of Group Ill and IV. CONCLUSION: Recovery in the group treated with local dexamethasone was more remarkable than that in the group treated with systemic dexamethasone in our study. As the difference was statistically significant, we recommend the perioperative use of local dexamethasone in procedures that might induce nerve injury.en_US
dc.identifier.doi10.5137/1019-5149.JTN.7761-13.0
dc.identifier.endpage629en_US
dc.identifier.issn1019-5149
dc.identifier.issue5en_US
dc.identifier.pmid24101310en_US
dc.identifier.scopus2-s2.0-84888396634en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage623en_US
dc.identifier.trdizinid177200en_US
dc.identifier.urihttps://dx.doi.org/10.5137/1019-5149.JTN.7761-13.0
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8584
dc.identifier.volume23en_US
dc.identifier.wosWOS:000327575300008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTURKISH NEUROSURGICAL SOCen_US
dc.relation.ispartofTURKISH NEUROSURGERYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY03711
dc.subjectDexamethasoneen_US
dc.subjectNerve injuryen_US
dc.subjectSciatic nerveen_US
dc.titleComparison of the Effects of Local and Systemic Dexamethasone on the Rat Traumatic Sciatic Nerve Modelen_US
dc.typeArticle
dspace.entity.typePublication

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