Regulation of mitogen activated protein kinases through heterotrimeric G proteins

Basit Öğe Kaydı
dc.contributor.authorKucukkaya, Bahire
dc.contributor.authorAfrasyap, Lale
dc.date.accessioned2024-07-12T21:58:20Z
dc.date.available2024-07-12T21:58:20Z
dc.date.issued2013en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractHeterotrimeric G proteins are known as G proteins, consist of alpha, beta, and gamma subunits. G protein mediated signaling is employed by virtually all cells in the mammalian organism and is centrally involved in diverse physiological functions such as perception of sensory information, modulation of synaptic transmission, hormone release and actions, regulation of cell contraction and migration, or cell growth and differentiation. The amino acid identity of the alpha subunits has been used as basis for the classification of G proteins into four families G(s), G(i), G(q), and G(12). G proteins stimulate distinct downstream effectors including enzymes, ion channels and small GTPase, thus regulating multiple signaling pathways including those involved in the activation of mitogen-activated protein kinase pathways. Mitogen-activated protein kinases are a family that constitute signaling pathways involved in processes that control gene expression, cell division, cell survival, apoptosis, metabolism, differentiation and motility. The mitogen-activated protein kinase family includes ERK1/2, c-Jun N-terminal kinazlar 1, 2 ve 3, p38MAPK alpha, beta, gamma, and delta, and ERK5 as classical mitogen-activated protein kinases, and ERK3, ERK4 NLK, and ERK7 as atypical mitogen-activated protein kinases. Each of mitogen-activated protein kinase pathways consists of three distinct kinases, namely an upstream respectively; mitogen-activated protein kinase kinase kinase, mitogen-activated protein kinase kinase and mitogen-activated protein kinaseen_US
dc.identifier.doi10.5505/tjb.2013.62534
dc.identifier.endpage228en_US
dc.identifier.issn0250-4685
dc.identifier.issn1303-829X
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-84879912336en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage218en_US
dc.identifier.urihttps://dx.doi.org/10.5505/tjb.2013.62534
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8782
dc.identifier.volume38en_US
dc.identifier.wosWOS:000323181600014en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isotren_US
dc.publisherWALTER DE GRUYTER GMBHen_US
dc.relation.ispartofTURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISIen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY09303
dc.subjectHeterotrimeric G proteinsen_US
dc.subjectG proteinsen_US
dc.subjectMitogen activated protein kinaseen_US
dc.subjectMAP Kinaseen_US
dc.subjectMAPKen_US
dc.titleRegulation of mitogen activated protein kinases through heterotrimeric G proteinsen_US
dc.typeReview
dspace.entity.typePublication

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu