Regulation of mitogen activated protein kinases through heterotrimeric G proteins
Küçük Resim Yok
Tarih
2013
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
WALTER DE GRUYTER GMBH
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Heterotrimeric G proteins are known as G proteins, consist of alpha, beta, and gamma subunits. G protein mediated signaling is employed by virtually all cells in the mammalian organism and is centrally involved in diverse physiological functions such as perception of sensory information, modulation of synaptic transmission, hormone release and actions, regulation of cell contraction and migration, or cell growth and differentiation. The amino acid identity of the alpha subunits has been used as basis for the classification of G proteins into four families G(s), G(i), G(q), and G(12). G proteins stimulate distinct downstream effectors including enzymes, ion channels and small GTPase, thus regulating multiple signaling pathways including those involved in the activation of mitogen-activated protein kinase pathways. Mitogen-activated protein kinases are a family that constitute signaling pathways involved in processes that control gene expression, cell division, cell survival, apoptosis, metabolism, differentiation and motility. The mitogen-activated protein kinase family includes ERK1/2, c-Jun N-terminal kinazlar 1, 2 ve 3, p38MAPK alpha, beta, gamma, and delta, and ERK5 as classical mitogen-activated protein kinases, and ERK3, ERK4 NLK, and ERK7 as atypical mitogen-activated protein kinases. Each of mitogen-activated protein kinase pathways consists of three distinct kinases, namely an upstream respectively; mitogen-activated protein kinase kinase kinase, mitogen-activated protein kinase kinase and mitogen-activated protein kinase
Açıklama
Anahtar Kelimeler
Heterotrimeric G proteins, G proteins, Mitogen activated protein kinase, MAP Kinase, MAPK
Kaynak
TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
WoS Q Değeri
Q4
Scopus Q Değeri
Q4
Cilt
38
Sayı
2
