Sphingosine-1-phosphate (S1P) receptors in nonmetastatic and metastatic breast cancer patients

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dc.authorid0000-0003-3771-3277en_US
dc.contributor.authorTurgut Coşan, Didem
dc.contributor.authorSoyocak, Ahu
dc.contributor.authorÇalış, I. U.
dc.contributor.authorÖner, Çağrı
dc.contributor.authorMetcalfe, E.
dc.contributor.authorErkasap, S.
dc.contributor.authorMutlu, F.
dc.date.accessioned2024-07-12T20:59:37Z
dc.date.available2024-07-12T20:59:37Z
dc.date.issued2018en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractIntroduction: S1P receptors S1P1 and S1P3 encourage cancer progression. In this study, the aim was to evaluate the functional roles in the progression of disease by determining the expression of S1P1 and S1P3 in non-metastatic and metastatic breast cancer. Materials and Methods: Breast tissue specimens were obtained by surgery and reduction mammoplasty. The peripheral mononuclear cells (PBMC) of non-metastatic, metastatic breast cancer patients and noncancerous individuals were also taken. Total RNA isolation was carried out by tissues and cells. Gene expression of S1P1 and S1P3 was determined by Real-Time PCR. Results: In this study, S1P1 and S1P3 gene expressions in tissues (1.03 and 1.16 fold, respectively) were found to be higher than PBMC samples in non-metastatic breast cancer patients. In addition, in PBMC samples S1P1 levels decreased by 2.90 fold in patients with non-metastatic breast cancer, increased by 1.33 fold in patients with metastatic breast cancer. S1P3 levels decreased by 3.35 fold in patients with non-metastatic breast cancer and 1.45 fold in patients with metastatic breast cancer. Conclusions: The result of our study showed that both gene expressions were higher in cancerous tissues than in normal tissues. The expression of the S1P1 gene in PBMCs is increased in nonmetastatic breast cancer patients compared to non-cancer individuals, while it is increased in metastatic breast cancer patients. S1P3 is lower in both non-metastatic and metastatic individuals than non-cancer individuals. These results indicate that, for the S1P receptors in the studies done in PBMC and tissue samples should be considered different expression properties.en_US
dc.identifier.citationTurgut Coşan, D., Soyocak, A., Çalış, I.U. vd. (2018). Sphingosine-1-phosphate (S1P) receptors in nonmetastatic and metastatic breast cancer patients. Abstracts from the 50th European Society of Human Genetics Conference: Electronic Posters içinde (ss. 967-968). Denmark: Nature.en_US
dc.identifier.endpage968en_US
dc.identifier.startpage967en_US
dc.identifier.urihttps://www.nature.com/articles/s41431-018-0248-6
dc.identifier.urihttps://hdl.handle.net/20.500.12415/3323
dc.institutionauthorÖner, Çağrı
dc.language.isoenen_US
dc.publisherNatureen_US
dc.relation.ispartofAbstracts from the 50th European Society of Human Genetics Conference: Electronic Postersen_US
dc.relation.isversionof10.1038/s41431-018-0248-6en_US
dc.relation.publicationcategoryUluslararası Konferans Öğesien_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY07216
dc.titleSphingosine-1-phosphate (S1P) receptors in nonmetastatic and metastatic breast cancer patientsen_US
dc.typeConference Object
dspace.entity.typePublication

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