Neurocognitive Functions in Bipolar Disorder in Relation to Comorbid ADHD

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dc.authoridCeylan, Deniz/0000-0002-1438-8240en_US
dc.authoridOZERDEM, AYSEGUL/0000-0002-9455-5896en_US
dc.contributor.authorArat Çelik, Hidayet Ece
dc.contributor.authorCeylan, Deniz
dc.contributor.authorHidiroğlu Ongun, Ceren
dc.contributor.authorErdoğan, Ayşe
dc.contributor.authorTan, Devran
dc.contributor.authorGumuskesen, Peren
dc.contributor.authorBagci, Basak
dc.date.accessioned2024-07-12T21:37:28Z
dc.date.available2024-07-12T21:37:28Z
dc.date.issued2021en_US
dc.department[Belirlenecek]en_US
dc.description.abstractIntroduction: Bipolar disorder (BD) and attention deficit hyperactivity disorder (ADHD) often co-occur in adult population. Both conditions present various neurocognitive and behavioral problems. We aimed to examine neurocognitive functions in adult patients with comorbid BD and ADHD (BD+ADHD) in comparison to patients with only BD, only ADHD and healthy controls (HCs). Method: An extensive cognitive battery which evaluates verbal learning and memory, visual memory, processing speed, attention, executive functions, working memory and verbal fluency, was used to assess neurocognitive functions respectively in adult (age 18-65 years) patients with BD (n=37), ADHD (n=43), BD+ADHD (n=20) in comparison to HCs (n=51). The Multivariate Analysis of Covariance models, where age, level of education and total BIS-11 scores were included as covariates, were used for comparing neurocognitive scores among groups. Results: Both BD and BD+ADHD groups showed significantly poorer performance than HCs in processing speed, attention, executive functions, and verbal fluency domains. The BD group had additional significant deficits in executive functions, verbal learning and memory domains. There were no significant differences between BD and BD+ADHD groups with regards to verbal learning and memory, visual memory, processing speed, attention, executive functions, working memory and verbal fluency domains. Patients with only ADHD showed significantly poorer performance than HCs in verbal fluency domain. Conclusions: Our results show similarities in the neurocognitive functions of adults with BD and BD+ADHD across a wide range of cognitive domains. The findings point to the need for further exploration of diverging and converging neurodevelopmental trajectories of BD and ADHD.en_US
dc.identifier.doi10.29399/npa.27290
dc.identifier.endpage93en_US
dc.identifier.issn1300-0667
dc.identifier.issn1309-4866
dc.identifier.issue2en_US
dc.identifier.pmid34188588en_US
dc.identifier.scopus2-s2.0-85109653823en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage87en_US
dc.identifier.trdizinid459001en_US
dc.identifier.urihttps://doi.org/10.29399/npa.27290
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/459001
dc.identifier.urihttps://hdl.handle.net/20.500.12415/6792
dc.identifier.volume58en_US
dc.identifier.wosWOS:000662245500003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTurkish Neuropsychiatry Assoc-Turk Noropsikiyatri Dernegien_US
dc.relation.ispartofNoropsikiyatri Arsivi-Archives of Neuropsychiatryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY04134
dc.subjectBipolar Disorderen_US
dc.subjectAttention Deficit Hyperactivity Disorderen_US
dc.subjectNeurocognitive Functionsen_US
dc.titleNeurocognitive Functions in Bipolar Disorder in Relation to Comorbid ADHDen_US
dc.typeArticle
dspace.entity.typePublication

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