Prognostic significance of thrombocytosis in node-negative colon cancer
Küçük Resim Yok
Tarih
2005
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Sage Journals
Erişim Hakkı
CC0 1.0 Universal
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess
Özet
Several clinical studies have shown that thrombocytosis is a poor prognostic factor in some types of cancer, but data about the impact of thrombocytosis on prognosis in patients with colon cancer are very limited. We investigated the prevalence and prognostic effect of pre-operative thrombocytosis, defined as a platelet count > 400 × 109/l, retrospectively in patients with node-negative colon cancer. Out of 198 patients, 24 (12.1%) had thrombocytosis, and its presence correlated with tumour depth and lymphatic invasion. Univariate analysis revealed that disease-free survival and overall survival were shorter in patients with pre-operative thrombocytosis than those without thrombocytosis. On multivariate analysis, thrombocytosis alone retained significance as a poor prognostic factor for both disease-free survival and overall survival. In conclusion, this study shows an association between thrombocytosis and poor survival in patients with node-negative colon cancer. The pre-operative platelet count may help to identify patients with an unfavourable prognosis in this subgroup.
Açıklama
Anahtar Kelimeler
Node-negative colon cancer, Thrombocytosis, Prognostic factors
Kaynak
Journal of International Medical Research
WoS Q Değeri
Scopus Q Değeri
Q3
Cilt
33
Sayı
2
Künye
Kandemir, E. G., Mayadagli, A., Karagoz, B., Bilgi, O., Turken, O. ve Yaylaci, M. (2005). Prognostic significance of thrombocytosis in node-negative colon cancer. The Journal of international medical research, Sage Journals. 33(2), 228–235.
