The importance of 3D cell culture in drug discovery and development

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dc.authorid0000-0002-5501-3736
dc.authorid0000-0002-7330-1301
dc.contributor.authorDemirel, Gamze
dc.contributor.authorKoltuk, Gürsel
dc.date.accessioned2025-01-08T12:19:08Z
dc.date.available2025-01-08T12:19:08Z
dc.date.issued2024
dc.departmentRektörlük, Rektörlüğe Bağlı Birimler, Kanser ve Kök Hücre Araştırma ve Uygulama Merkezi
dc.description.abstractThree-dimensional (3D) cell culture techniques represent a transformative advancement in biomedical research, particularly in drug discovery and development. By more closely replicating the physiological and microenvironmental conditions of in vivo tissues, 3D cell cultures enable more accurate assessments of drug efficacy, toxicity, and therapeutic potential compared to traditional two-dimensional (2D) cultures. These systems not only provide a more realistic model for preclinical testing but also allow for the study of complex cell-cell and cell-matrix interactions, which are often overlooked in 2D systems. This review provides a comprehensive examination of studies utilizing spheroids and organoids in 3D culture systems for drug screening and development. Furthermore, it highlights the critical role of these models in uncovering novel therapeutic targets, understanding disease mechanisms, and optimizing drug delivery strategies. Key challenges, such as scalability, standardization, and integration with high-throughput screening platforms, are also discussed. In conclusion, 3D cell culture techniques hold immense promise for revolutionizing the drug discovery pipeline, offering a more predictive and ethical approach to preclinical research while bridging the gap between laboratory findings and clinical outcomes.
dc.identifier.citationDemirel, G. ve Koltuk, G. (2024). The importance of 3D cell culture in drug discovery and development, Frontiers in Life Sciences and Related Technologies, İbrahim İlker ÖZYİĞİT, 5(3), s.224-230.
dc.identifier.doi10.51753/flsrt.1488871
dc.identifier.endpage230
dc.identifier.issn2718-062X
dc.identifier.issue3
dc.identifier.startpage224
dc.identifier.urihttps://dergipark.org.tr/en/pub/flsrt/issue/89205/1488871
dc.identifier.urihttps://hdl.handle.net/20.500.12415/13215
dc.identifier.volume5
dc.language.isoen
dc.publisherİbrahim İlker ÖZYİĞİT
dc.relation.ispartofFrontiers in Life Sciences and Related Technologies
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subject3D Cell Culture
dc.subjectDrug Discovery
dc.subjectOrganoids
dc.subjectSpheroid
dc.titleThe importance of 3D cell culture in drug discovery and development
dc.typeArticle
dspace.entity.typePublication

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