Evaluation of carotid wall thickness and vertebro-basilar system insufficiency in patients with obese polycystic ovary syndrome

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dc.authorid0000-0002-3166-9052en_US
dc.contributor.authorCoksuer, Hakan
dc.contributor.authorKoplay, Mustafa
dc.contributor.authorOghan, Fatih
dc.contributor.authorHaliloglu, Berna
dc.contributor.authorKeskin, Nadi
dc.date.accessioned2024-07-12T21:51:10Z
dc.date.available2024-07-12T21:51:10Z
dc.date.issued2011en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractAim: To investigate the risk of cardiovascular disease by measuring carotid intima-media thickness (CIMT) and to evaluate the diameters and blood flow volume of vertebral arteries using Doppler ultrasound and the possible contribution of hyperandrogenemia that exists in these patients. Material and Methods: We prospectively studied 64 Caucasian women aged 18-35 years (31 with polycystic ovary syndrome [PCOS] and 33 healthy controls). Patients were classified according to body mass index into obese (BMI > 27 kg/m(2)). All subjects were examined with ultrasound to measure CIMT and blood flow volume and diameters of vertebral arteries. Results: A significant difference between the two groups in CIMT (0.51 +/- 0.08 vs 0.39 +/- 0.02 mm, P < 0.001) and diameters of vertebral arteries (right, 3.03 +/- 0.37 vs 3.44 +/- 0.68 mm and left, 2.94 +/- 0.34 vs 3.33 +/- 0.63 mm, P < 0.05) were found, respectively. Right-left and total flow volumes of the vertebral arteries (VA) were significantly lower in the PCOS group than in the control group (P <= 0.001). Compared to the control group, diameters of right and left VA decreased (P < 0.05). Conclusion: The results of this study suggest that hyperandrogenemia in obese PCOS patients affects carotid and vertebro-basilar system arteries wall thickness. Pre-atherosclerotic vascular impairment with androgen excess should determine early examination of vertebro-basilar system with ultrasound. All patients with PCOS must be routinely examined using color Doppler ultrasound to measure CIMT carotid and vertebro-basilar arteries, and diameters and blood flow volume of vertebral arteries.en_US
dc.identifier.doi10.1111/j.1447-0756.2010.01472.x
dc.identifier.endpage1003en_US
dc.identifier.issn1341-8076
dc.identifier.issn1447-0756
dc.identifier.issue8en_US
dc.identifier.pmid21463430en_US
dc.identifier.scopus2-s2.0-80052696276en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage997en_US
dc.identifier.urihttps://dx.doi.org/10.1111/j.1447-0756.2010.01472.x
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8245
dc.identifier.volume37en_US
dc.identifier.wosWOS:000293234700005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofJOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY01997
dc.subjectcarotid intima-media thicknessen_US
dc.subjectobesityen_US
dc.subjectpolycystic ovary syndrome/hyperandrogenismen_US
dc.subjectvertebro-basilar flow volumeen_US
dc.titleEvaluation of carotid wall thickness and vertebro-basilar system insufficiency in patients with obese polycystic ovary syndromeen_US
dc.typeArticle
dspace.entity.typePublication

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