Hemostatic changes in active pulmonary tuberculosis

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dc.authorid0000-0002-4075-6692en_US
dc.contributor.authorKunter, E.
dc.contributor.authorSezer, M.
dc.contributor.authorSolmazgül, E.
dc.contributor.authorCerrahoğlu, K.
dc.contributor.authorBozkanat, E.
dc.contributor.authorÖztürk, A.
dc.contributor.authorİlvan, A.
dc.date.accessioned2024-07-12T21:04:21Z
dc.date.available2024-07-12T21:04:21Z
dc.date.issued2002en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractObjective: Severe pulmonary tuberculosis (PTB) is sometimes complicated by deep vein thrombosis (DVT). We have searched for possible hemostatic disturbances that are predisposing factors for venous thrombosis in patients with PTB. Design: Coagulation and platelet function tests were studied in 45 patients with active PTB and 20 healthy control volunteers before therapy. Findings were compared with results at 30 days. Results: Analysis in patients with active PTB showed anemia, leucocytosis, thrombocytosis, elevation in plasma fibrinogen, factor VIII, plasminogen activator inhibitor 1 (PAI-1) with depressed antithrombin III (AT III) and protein C (PC) levels. On the 30th day of treatment, anemia, leucocytosis and thrombocytosis were improved. Fibrinogen and factor VIII levels had decreased to normal levels, PC and AT III levels had increased to normal levels, and there was no difference in PAI-1 levels. We found no activated protein C resistance. Platelet aggregation studies demonstrated increased platelet activation. However, DVT was not detected in patients during the follow-up period. Conclusion: Decreased AT III, PC and elevated plasma fibrinogen levels and increased platelet aggregation appear to induce a hypercoagulable state seen in PTB and improve with treatment.en_US
dc.identifier.citationTürken, O., Kunter, E. Sezer, M., Solmazgül, E., Cerrahoğlu, K., Bozkanat, E., Öztürk, A. ve İlvan, A. (2002). Hemostatic changes in active pulmonary tuberculosis. International journal of tuberculosis and lung disease, Ingenta Connect. 6(10), s. 927-932.en_US
dc.identifier.endpage932en_US
dc.identifier.issue10en_US
dc.identifier.startpage927en_US
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/12365581/
dc.identifier.urihttps://hdl.handle.net/20.500.12415/3777
dc.identifier.volume6en_US
dc.institutionauthorTürken, Orhan
dc.language.isoenen_US
dc.publisherIngenta Connecten_US
dc.relation.ispartofInternational journal of tuberculosis and lung diseaseen_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıen_US
dc.rightsCC0 1.0 Universal*
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/*
dc.snmzKY01692
dc.subjectantithrombin IIIen_US
dc.subjecthypercoagulabilityen_US
dc.subjectplasminogen activator inhibitoren_US
dc.subjectprotein Cen_US
dc.subjecttuberculosisen_US
dc.titleHemostatic changes in active pulmonary tuberculosisen_US
dc.typeArticle
dspace.entity.typePublication

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