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    Childhood trauma in alcoholics
    (OXFORD UNIV PRESS, 2004) Mirsal, H; Kalyoncu, A; Pektas, O; Tan, D; Beyazyurek, M
    Aims: Many studies have been conducted to evaluate the relationship between childhood trauma and alcoholism. In this study 80 alcoholics were chosen according to their hospitalization order. The control group consisted of 60 subjects, with no history of alcohol use, matched with the patient group in age and sex. Methods: A sociodemographic and clinical data form, a questionnaire focusing on traumatic life experiences in childhood and The Childhood Trauma Questionnaire, Hamilton Depression Rating Scale, and Hamilton Anxiety Rating Scale were applied to both groups. Results: Significant differences were found between the two groups on traumatic life experiences in childhood. Results suggested that childhood trauma positively correlates with anxiety and affective symptoms among alcoholics. Conclusions: Further studies are needed concerning this issue.
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    Increased mirror movements after epileptic seizure in a case of polymicrogyria
    (LIPPINCOTT WILLIAMS & WILKINS, 2006) Sahin, S; Tan, D; Aydin, S; Kiziltan, M; Karsidag, S
    Background: Mirror movements (MM) are involuntary movements during the voluntary movements of the contralateral homologous body parts. Review Summary: We report a patient with an increase in MM after suffering an epileptic seizure of his upper and lower limbs due to the right frontoparietal polymicrogyria, including the supplementary motor area as evidenced by magnetic resonance imaging. MM have been investigated using transcranial magnetic stimulation and other electrophysiological techniques in our case. Conclusion: This case is notable in that it is the first recorded observation of a patient manifesting mirroring after apparently suffering an epileptic seizure. In our case, we suggest that epileptic seizure increases MM by inducing cortical reorganization.
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    Major depressive disorder with psychotic features induced by interferon-alpha treatment for hepatitis C in a polydrug abuser
    (SAGE PUBLICATIONS LTD, 2005) Kalyoncu, OA; Tan, D; Mirsal, H; Pektas, O; Beyazyurek, M
    Infectious diseases, especially hepatitis C, are prevalent among drug abusers. Interferon-alpha (IFN-alpha) is the pharmacological treatment of choice for this condition. Patients being treated with IFN-alpha can be expected to experience such psychiatric side-effects as development of depression, mania, irritability, changes in personality, hallucinations or delirium. In addition, certain patients are considered to be at greater risk of developing neuropsychiatric side-effects. Individuals meeting the following criteria are particularly vulnerable: over 40 years of age; having central nervous system abnormalities; a previous neurological or psychiatric history; a past familial psychiatric history; use of narcotics or having alcohol or substance use disorders; being HIV-positive; coadministration of other cytokines; receiving high doses of IFN-alpha (> 6 million units). We report the case of a 29-year-old patient with chronic non-active hepatitis C, a previous psychiatric history of polydrug abuse (cannabis, heroin and illegal use of the psychotropic drug biperiden) and anxiety disorder. Two weeks after the initiation of IFN-alpha treatment, he developed fatigue, sleeplessness and persecutory delusions. The patient responded partially to the discontinuation of the IFN-alpha treatment. Due to the presence of three risk factors in this patient, he was considered to belong to the group of patients being 'at high risk' of developing neuropsychiatric side-effects. This is the first case report of major depressive disorder with psychotic features in such a 'high-risk patient' This case report may prompt other research by showing the importance of the close monitoring, and the prevention of the progression of IFN-alpha-related psychiatric disorders in 'at high-risk patient'.
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    Use of lamotrigine to augment clozapine in patients with resistant schizophrenia and comorbid alcohol dependence: a potent anti-craving effect?
    (SAGE PUBLICATIONS LTD, 2005) Kalyoncu, A; Mirsal, H; Pektas, O; Unsalan, N; Tan, D; Beyazyurek, M
    Comorbid alcohol dependence is common in patients with schizophrenia and is associated with a variety of serious adverse consequences. Although case reports exist concerning the positive impact of lamotrigine addition on clozapine treatment in resistant schizophrenia, a review of the literature fails to document any evidence regarding a combination of the two in the treatment of patients with schizophrenia and comorbid alcohol dependence. In the present study, we present three cases in which patients with resistant schizophrenia and comorbid alcohol use disorder were given lamotrigine to augment clozapine. Our findings suggest that clozapine plus lamotrigine may be helpful inreducing alcohol consumption and craving among patients with schizophrenia and comorbid alcohol dependence.