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Yayın THE ANALYSIS OF CULTURE RESULTS OF THE RIMS THAT BELONG TO THE DONOR CORNEAS WITH OR WITHOUT VANCOMYCINE APPLICATION IN PENETRATING KERATOPLASTY OPERATIONS(NOBEL ILAC, 2009) Yigit, Ulviye; Bilen, Harun; Agachan, Ahmet; Ozdemir, Secil; Helvacioglu, Firat; Sencan, SadikObjective: The purpose of this paper is to compare the culture results of donor corneas in penetrating keratoplasty operations with or without vancomycine application and to evaluate the efficacy of vancomycine. Material and Method: The study was performed on Haseki Eye Bank corneas from as a prospective, randomised, double blind and multicentered study. 94 donor corneas of 47 bodies were included. The corneal tissues taken from the corpses were carried to the tissue supply center in Optisol-GS solution (gentamycine, strepto-mycine). In tissue supply center the corneas taken from the same body were divided into two groups and sent to two different surgeons. Mile 1 mg/ml vancomycine was applied to the corneas in the first group for 5 minutes, nothing was clone to the corneas in the second group. All corneal rims were carried to the microbiology lab in sterile tubes. Results: Postoperative endophthalmitis was observed in none of the 94 eyes which the corneas were transplanted with or with-out vancomycine application. Mile the culture results in 2 (4.3%) of the 47 donor rim tissues which vancomycine was applied were positive, 6 (12.7%) of the 47 donor rim tissues without vancomycine application were positive. No statistically significance was observed between the two groups. On the side in two donor corneas taken from the same body the same bactery type was positive. Conclusion: Althought no significant difference was observed in this study, we believe that, as the literature supports, with the increase in the number of the cultured corneas statistically significant results will be reached.Yayın Bilateral Mutifocal Intraocular Lens Implantation on an Postoperative Hyperopic Patient(Turkish Ophthalmological Soc, 2009) Tunç, Z.; Ercalik, Yeşim; Sencan, SadikPurpose: Presentation of our bilateral multifocal intraocular lens (IOL) implantation results on an bilateral postoperative hyperopic laser in situ keratomileusis (LASIK) patient. Material-Methods: In April 2007, a female, 10 year- postoperative bilateral hyperopic LASIK patient was implanted by the same surgeon with bilateral multifocal IOLs following a facoemulsification operation, because she had developed cataract. Patients preoperative and postoperative visual acuities (distance, near and intermediate on both Snellen and Jaeger charts), corneal topography, keratometry values and postoperative contrast sensitivity results were followed up. Power of the IOL was calculated according to clinical narrative method. Patient was also asked questions regarding her quality of life, light reflections and personal satisfaction. Results: 70 year old female subject had received hyperopic LASIK treatment 10 years ago (OD: +3.75 D; OS: +3.50 -0.50 90 D). After cataract has developed, in April 2007, patient received bilateral multifocal IOL implantation following facoemulsification surgery. Right eye received a refractive IOL, while left eye received an aspheric diffractive IOL. At 2 months postoperative, uncorrected visual acuities were as follows; distant 0.8 and 1.0, near J3 and J1, intermediate J5 and J3. Postoperative best corrected visual acuities were as follows; distant 1.0 and 1.0, near J1 and J1, intermediate J2 and J1. At 2 months, postoperative refraction values were -0.75 D for the right eye and +0.00 for the left eye. Contrast sensitivity tests were conducted at 4th, 6th months and 1 year postop and improvement was observed. Patient noted the glare problems were diminishing by day. Overall satisfaction was rated as good. Conclusion: Our bilateral hyperopic LASIK patient was satisfied following the bilateral multifocal IOL implantation. Although the result is encouraging, further studies on more subjects are needed for proving the effectiveness and safety of the technique.Yayın Comparison of Two Different Ultrasound Methods of Phacoemulsification(ELSEVIER SCIENCE INC, 2014) Helvacioglu, Firat; Yeter, Celal; Sencan, Sadik; Tunc, Zeki; Uyar, O. MuratPURPOSE: To compare the safety and efficacy of micro-coaxial phacoemulsification surgeries performed with the OZil Intelligent Phaco torsional mode (Alcon Laboratories, Inc., Fort Worth, USA) and combined torsional/longitudinal ultrasound mode using 45 degree aperture angled tips. DESIGN: Prospective randomized clinical trial. METHODS: SETTING: Maltepe University, Istanbul. PATIENT POPULATION: Eighty eyes of 80 cataract patients were randomly assigned to 2.2 mm microcowdal phacoemulsification using the OZil Intelligent Phaco torsional mode (Group 1) or combined torsional/longitudinal ultrasound mode (Group 2). OBSERVATION PROCEDURE: Intraoperative fluid and energy usage and postoperative examinations were evaluated. MAIN OUTCOME MEASURES: Ultrasound time, cumulative dissipated energy, longitudinal and torsional ultrasound amplitudes, mean operation time, mean volume of fluid used, and surgical complications. RESULTS: Both groups included 40 eyes. Mean ultrasound time, cumulative dissipated energy, and longitudinal and torsional ultrasound amplitudes in Group 1 were 58.21 +/- 33.81 seconds, 7.74 +/- 6.23, 0.45 +/- 0.30, and 26.30 +/- 12.60%, respectively, and these parameters in Group 2 were 64.75 +/- 30.23 seconds, 12.61 +/- 6.21, 26.32 +/- 5.85, and 40.98 +/- 8.33%, respectively. Cumulative dissipated energy and longitudinal and torsional amplitudes were found to be significantly lower in Group 1 (P = .001, P < .001, P < .001). Mean volumes of fluid used in Groups 1 and 2 were 73.30 +/- 19.87 cc and 107.07 +/- 21.82 cc, respectively (P < .001). CONCLUSION: With the aid of a 45 degree aperture angled tip, the OZil Intelligent Phaco torsional mode provided more effective lens removal than the combined torsional/longitudinal ultrasound mode, with a lower cumulative dissipated energy and volume of fluid used. (C) 2014 by Elsevier Inc. All rights reserved.Yayın Evaluation of intrastromal corneal ring segments for treatment of keratoconus with a mechanical implantation technique(WOLTERS KLUWER MEDKNOW PUBLICATIONS, 2013) Tunc, Zeki; Helvacioglu, Firat; Sencan, SadikPurpose: To evaluate the clinical outcomes of intrastromal corneal ring segment (ICRS) implantation in patients with keratoconus using a mechanical implantation technique. Materials and Methods: Thirty eyes of 17 patients with keratoconus were enrolled. ICRSs (Keraring) were implanted after dissection of the tunnel using Tunc's specially designed dissector under suction. A complete ophthalmic examination was performed, including uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), spherical equivalent, keratometric readings, inferosuperior asymmetry index (ISAI), and ultrasound pachymetry. All 3-, 6-, and 12-month follow-ups were completed, and statistical analysis was performed. Results: The mean preoperative UDVA for all eyes was 1.36 +/- 0.64 logMAR. At 12 months, the mean UDVA was 0.51 +/- 0.28 logMAR (P = 0.001), and the mean preoperative CDVA was 0.57 +/- 0.29 logMAR, which improved to 0.23 +/- 0.18 (P = 0.001) at 1 year. There was a significant reduction in spherical equivalent refractive error from -6.42 +/- 4.69 diopters (D) preoperatively to -1.26 +/- 1.45 D (P = 0.001) at 1 year. In the same period, the mean K-readings improved from 49.38 +/- 3.72 D to 44.43 +/- 3.13 D (P = 0.001), and the mean ISAI improved from 7.92 +/- 3.12 to 4.21 +/- 1.96 (P = 0.003). No significant changes in mean central corneal thickness were observed postoperatively. There were no major complications during and or after surgery. Conclusion: ICRS implantation using a unique mechanical dissection technique is a safe and effective treatment for keratoconus. All parameters improved by the 1-year follow-up.Yayın Evaluation of intrastromal corneal ring segments for treatment of post-LASIK ectasia patients with a mechanical implantation technique(WOLTERS KLUWER MEDKNOW PUBLICATIONS, 2011) Tunc, Zeki; Helvacioglu, Firat; Sencan, SadikAim: To evaluate the clinical outcomes of Keraring segment implantation in patients with post-laser-assisted in situ keratomileusis (LASIK) ectasia, using a mechanical implantation technique. Materials and Methods: Twelve eyes of 10 patients with post-LASIK ectasia were enrolled. Intracorneal ring segments (ICRS) were implanted aft er dissection of the tunnel using Tunc's specially designed dissector under suction. A complete ophthalmic examination was performed, including uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), spherical equivalent, keratometric (K) readings, inferosuperior asymmetry index (ISAI), and ultrasound pachymetry. All 3, 6, and 12-month follow-ups were completed, and statistical analysis was performed. Results: The mean preoperative UDVA for all eyes was 1.28 +/- 0.59 logMAR. At 12 months, the mean UDVA was 0.36 +/- 0.19 logarithm of the Minimum Angle of Resolution (logMAR) (P=0.002), and the mean preoperative CDVA was 0.58 +/- 0.3 logMAR, which improved to 0.15 +/- 0.12 (P=0.002) at 1 year. There was a significant reduction in cylindrical refractive and spherical equivalent refractive error from -5.29 +/- 2.47 diopters (D) and -5.54 +/- 5.04 D preoperatively to -1.47 +/- 0.71 D and -0.74 +/- 1.07 D (P=0.001, P=0.002), respectively, at 1 year. In the same period, the mean K-readings improved from 47.93 +/- 4.84 D to 40.87 +/- 2.36 D (P=0.002), and the mean ISAI improved from 5.34 +/- 3.05 to 2.37 +/- 1.68 (P=0.003). No significant changes in mean central corneal thickness were observed postoperatively. There were no major complications during or aft er surgery. Conclusion: ICRS implantation using a unique mechanical dissection technique is a safe and effective treatment for post-LASIK ectasia. All parameters showed improvement at 1-year follow-up.Yayın The Outcomes of Conventional and Bimanual Microincision Phacoemulsification Performed in Cataracts with Hard Nuclei(Turkish Ophthalmological Soc, 2008) Helvacioğlu, F.; Yigit, Ulviye; Sencan, Sadik; Özdemir, Secil; Kilic, MuratPurpose: To compare the safety and efficacy of bimanual microincision cataract surgery (MICS) and conventional phacoemulsification surgery performed in cataracts with hard nuclei. Methods: Between September 2005 and March 2006, MICS (Group 1) and conventional phaco (Group 2) were performed in 60 eyes of 60 patients. Patients with hard cataracts (grade34) were grouped randomly (both groups had 30 eyes) for the type of surgery. Patients were examined for intraoperative complications, mean phaco time, total phaco %, effective phaco time (EPT), % endothelial cell loss, postoperative corneal edema, anterior chamber reactions and mean uncorrected and best corrected visual acuities.. The safety and the efficacy of the systems were evaluated by the statistical analysis of surgical outcomes. Results: The mean US time, total phaco % and EPT were 132.20 seconds, 9.35% and 11.74 secs for G1 and 132.36 seconds, 8.41% and 10.69 secs for G2. The mean postoperative percentages of the endothelial cell losses were 8.5% for G1 and 8.6% for G2. The mean early postoperative uncorrected visual acuity and late postoperative best corrected visual acuity were 0.57 and 0.91 in snellen chart for G1 and 0.51 and 0.87 for G2. Mostly no or mild corneal edema and anterior chamber reactions were observed Conclusion: With the increased experience in bimanual technique and by the aid of adequate modern surgical systems MICS could be performed as safe and efficient as conventional phacoemulsification in cases with hard cataracts.Yayın Outcomes of torsional microcoaxial phacoemulsification performed by 12-degree and 22-degree bent tips(ELSEVIER SCIENCE INC, 2013) Helvacioglu, Firat; Yeter, Celal; Tunc, Zeki; Sencan, SadikPURPOSE: To compare the safety and efficacy of Ozil Intelligent Phaco torsional microcoaxial phacoemulsification surgeries performed with 12-degree and 22-degree bent tips using the Infiniti Vision System. SETTING: Maltepe University School of Medicine Department of Ophthalmology, Istanbul, Turkey. DESIGN: Comparative case series. METHODS: Eyes were assigned to 2.2 mm microcoaxial phacoemulsification using the torsional mode with a 22-degree bent tip (Group 1) or a 12-degree bent tip (Group 2). The primary outcome measures were ultrasound time (UST), cumulative dissipated energy (CDE), longitudinal and torsional ultrasound (US) amplitudes, mean surgical time, mean volume of balanced salt solution used, and surgical complications. RESULTS: Both groups included 45 eyes. The mean UST, CDE, longitudinal US amplitude, and torsional US amplitude were 65 seconds +/- 27.23 (SD), 11.53 +/- 6.99, 0.22 +/- 0.26, and 42.86 +/- 15.64, respectively, in Group 1 and 84 +/- 45.04 seconds, 16.68 +/- 10.66, 0.48 +/- 0.68, and 46.27 +/- 14.74, respectively, in Group 2. The mean UST, CDE, and longitudinal amplitudes were significantly lower in Group 1 (P=.003, P=.008, and P=.022, respectively). The mean volume of balanced salt solution was 73.33 +/- 28.58 cc in Group 1 and 82.08 +/- 26.21 cc in Group 2 (P=.134). CONCLUSION: Torsional phacoemulsification performed with 22-degree bent tips provided more effective lens removal than 12-degree bent tips, with a lower UST and CDE.Yayın Outcomes of torsional microcoaxial phacoemulsification using tips with 30-degree and 45-degree aperture angles(ELSEVIER SCIENCE INC, 2014) Helvacioglu, Firat; Sencan, Sadik; Yeter, Celal; Tunc, Zeki; Uyar, O. MuratPURPOSE: To compare the safety and efficacy of Ozil Intelligent Phaco torsional microcoaxial phacoemulsification surgeries performed using 30-degree and 45-degree aperture angled tips. SETTING: Maltepe University School of Medicine Department of Ophthalmology, Istanbul, Turkey. DESIGN: Comparative case series. METHODS: Eyes were assigned to 2.2 mm microcoaxial phacoemulsification using the torsional mode with a 45-degree (Group 1) or 30-degree (Group 2) aperture angled tip. A quick-chop surgical technique was used. The primary outcome measures were ultrasound time (UST), cumulative dissipated energy (CDE), longitudinal and torsional ultrasound (US) amplitudes, mean surgical time, mean balanced salt solution volume used, and mean central corneal thickness (CCT) changes. RESULTS: The mean UST, CDE, and longitudinal and torsional US amplitudes were 58.21 seconds +/- 33.81 (SD), 7.74 +/- 6.23, 0.45 +/- 0.30, and 26.30 +/- 12.60 in Group 1 and 63.83 +/- 23.42 seconds, 12.36 +/- 6.75, 0.23 +/- 0.26, and 44.65 +/- 14.38 in Group 2, respectively. The mean CDE and torsional amplitudes were significantly lower in Group 1 (P=.002 and P=.001, respectively). The mean balanced salt solution volume was 73.30 +/- 19.87 cc in Group 1 and 74.30 +/- 19.44 cc in Group 2 (P=.821). The mean CCT change was 52.40 +/- 38.08 mu m and 99.35 +/- 47.14 mu m, respectively (P<.001). CONCLUSION: Torsional phacoemulsification performed with a 45-degree aperture angled tip provided more effective lens removal with a lower CDE and less CCT change than a 30-degree aperture angled tip.Yayın Ozil IP torsional mode versus combined torsional/longitudinal microcoaxial phacoemulsification(WICHTIG EDITORE, 2012) Helvacioglu, Firat; Tunc, Zeki; Yeter, Celal; Oguzhan, Hasan; Sencan, SadikPURPOSE. To compare the safety and efficacy of microcoaxial phacoemulsification surgeries performed with the Ozil Intelligent Phaco (IP) torsional mode and combined torsional/longitudinal ultrasound (US) mode using the Infiniti Vision System (Alcon Laboratories). METHODS. In this prospective randomized comparative study, 60 eyes were assigned to 2.2-mm microcoaxial phacoemulsification using the Ozil IP torsional mode (group 1) or combined torsional/longitudinal US mode (group 2). The primary outcome measures were US time (UST), cumulative dissipated energy (CDE), longitudinal and torsional ultrasound amplitudes, mean operation time, mean volume of balanced salt solution (BSS) used, and surgical complications. RESULTS. Both groups included 30 eyes. Mean UST, CDE, and longitudinal and torsional ultrasound amplitudes in group 1 were 1 minute 15 +/- 34.33 seconds, 8.74 +/- 5.64, 0.43 +/- 0.74, and 25.56 +/- 8.56, respectively, and these parameters in group 2 were 1 minute 40 +/- 51.44 seconds, 9.28 +/- 5.99, 3.64 +/- 1.55, and 3.71 +/- 1.34, respectively. UST and longitudinal amplitudes were found to be significantly low in group 1 (p<0.001, p<0.001), whereas torsional amplitude was found to be significantly high in this group (p=0.001). Mean volumes of BSS used in groups 1 and 2 were 63.30 +/- 18.00 cc and 84.50 +/- 28.65 cc, respectively (p=0.001). CONCLUSIONS. The Ozil IP torsional mode may provide more effective lens removal than the combined torsional/longitudinal US mode with a lower UST and volume of BSS used.