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Yayın A case of urinary tract infection caused by Flavimonas oryzihabitans(ANKARA MICROBIOLOGY SOC, 2007) Topkaya, Aynur E.; Ozakkas, Fatma; Aksungar, Fehime B.; Tulbek, YasarFlavimonas oryzihabitans is an uncommon bacterial species isolated from clinical specimens. In this report, a 53 years old female patient who had been followed up with the diagnosis of rectum cancer and renal failure for five and two years, respectively, was presented. F.oryzihabitans was isolated from the urine culture of the patient, and the clinical response to ofloxacin therapy was excellent even the urinary catheter has not been removed. Although this pathogen is mostly community aquired, it was found resistant to most of the antimicrobial agents tested. Since it was susceptible to fluoroquinolones and carbapenems, these antibiotics could be the drug of choice for the treatment of infections caused by F.oryzihabitans. The aim of this presentation was to withdraw attention to this bacterium which is thought to be the first urine isolate in our country.Yayın Coagulation status and biochemical and inflammatory markers in multiple sclerosis(ELSEVIER SCI LTD, 2008) Aksungar, Fehime B.; Topkaya, Aynur E.; Yildiz, Zeynep; Sahin, Sevki; Turk, UlkuMultiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system and is the most common cause of neurologic disability in young adults. in this study, the coagulation status and biochemical and non-specific inflammatory markers in patients with MS were investigated. Plasma prothrombin time, activated partial thrombin time, fibrinogen, D-dimer, serum high sensitive C-reactive protein, homocysteine, blood urea nitrogen, creatinine, calcium, total protein, albumin, total cholesterol, vitamin B 12, folate levels and erythrocyte sedimentation rate were measured in 42 patients with MS and 31 healthy subjects as a control group. There was a positive correlation between homocysteine and D-dimer levels (r = 0.84, p < 0.01). However, there was no significant correlation between homocysteine, vitamin B12 (r = 0.18) and folate (r = 0.23) levels. Serum total protein, albumin and calcium levels of MS patients were lower than the control group. There are some alterations in the coagulation and biochemical status in MS patients. These findings may contribute to better understanding of the etiopathogenesis and clinical characteristics of this disease. (C) 2007 Elsevier Ltd. All rights reserved.Yayın Flavimonas oryzihabitans'ın etken olduğu bir üriner sistem enfeksiyonu olgusu(2007) Aksungar, Fehime B.; Tülbek, Yaşar; Özaktaş, Fatma; Topkaya, Aynur E.Flavimonas oryzihabitans klinik örneklerden nadiren izole edilen bir bakteri türüdür. Bu raporda, beş yıldır rektum kanseri ve iki yıldır böbrek yetmezliği nedeniyle izlenen 53 yaşındaki bir kadın hastanın idrar örneğinden izole edilen bir F.oıyzihabitans susu bildirilmektedir. Hastanın üreter kateteri çıkarıimaksızın uygulanan ofloksasin tedavisi ile oldukça iyi bir klinik yanıt alınmıştır. F.oryzihabitans'in toplum kaynaklı bir enfeksiyon etkeni olmasına karşın, test edilen birçok antimikrobiyal ajana karşı dirençli olduğu saptanmıştır. Ancak bakterinin florokinolon ve karbapenemlere duyarlı bulunması, tedavide bu grup antibiyotiklerin kullanılabileceğini göstermiştir. Yurdumuzda idrardan izole edilen ilk F.oryzihabitans susu olduğunu düşündüğümüz olgu, bu bakteriye dikkatin çekilmesi amacıyla sunulmaktadır.Yayın A grubu beta-hemolitik streptokokların antibiyotik duyarlılıkları(Antibiyotik ve Kemoterapi Derneği, 2007) Özakkaş, Fatma; Aksungar, Fehime B.; Eren Topkaya, AynurA grubu beta-hemolitik streptokoklar (Streptococcus pyogenes) bakteriyel farenjitlerin en sık saptanan etkenidir. Penisilin ve diğer beta-laktam antibiyotiklere henüz direnç bildirilmemiştir. Ancak, penisilin allerjisi olan veya tolerans varlığında hastaların tedavisinde alternatif olan makrolidlere karşı giderek artan oranlarda direnç bildirilmiştir. Bu çalışmada, Ocak 2006-Haziran 2006 tarihlerinde boğaz kültürlerinden izole edilen, 100 S.pyogenes suşunun ampisilin, seftriakson, azitromisin, tetrasiklin, kloramfenikol ve siprofloksasine duyarlılıkları araştırılmıştır. Suşların tümü ampisilin, seftriakson ve azitromisine duyarlı bulunmuştur. En yüksek direnç oranı kloramfenikol için saptanırken (% 19), bunu sırasıyla tetrasiklin (% 14) ve siprofloksasin (% 12) dirençleri izlemiştir. Test ettiğimiz makrolid grubu antibiyotik olan azitromisine karşı direnç olmaması, penisilin allerjisi ya da tolerans varlığında, bu gruptaki antibiyotiklerin üst solunum yolu infeksiyonlarının tedavisinde alternatif olabileceğini düşündürmektedir.Yayın Interleukin-6, C-reactive protein and biochemical parameters during prolonged intermittent fasting(KARGER, 2007) Aksungar, Fehime B.; Topkaya, Aynur E.; Akyildiz, MahmutBackground: It is well known that nutritional habits, sleeping patterns and meal frequency have profound effects on maintaining human health. Ramadan is a religious month for Islam, during which Muslims do not eat and drink during the daylight hours. The duration of restricted food and beverage intake is approximately 12 h/day for 1 month, which makes Ramadan a model of prolonged intermittent fasting. Methods: In order to evaluate the effects of long- lasting modifications of food intake on inflammatory markers and biochemical parameters 40 healthy volunteers of normal weight [ 20 females aged between 20 and 38 years, 20 males aged between 23 and 39 years, body mass index (BMI) < 25 kg/m(2)] who fasted during Ramadan and another 28 healthy age and BMI-matched volunteers (14 males, 14 females) who did not fast participated in the study. Venous blood samples were taken 1 week before Ramadan, during the last week of Ramadan and 3 weeks after Ramadan. Serum interleukin-6 (IL-6), C-reactive protein (CRP), homocysteine, vitamin B-12, folate, total cholesterol (TC), triglycerides, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) levels were measured. Results: No significant changes were observed in serum total cholesterol, triglycerides and LDL levels. TC/HDL ratio (HDL risk factor) was decreased during and after Ramadan in both genders in the fasting group while there were no changes in the nonfasting group. IL-6 (p < 0.001), CRP (p < 0.001) and homocysteine (p < 0.01) levels were significantly low during Ramadan in the fasting subjects of both genders when compared to basal values (1 week before Ramadan). Conclusion: Our results demonstrate that prolonged intermittent fasting in a model like Ramadan has some positive effects on the inflammatory status of the body and on the risk factors for cardiovascular diseases such as homocysteine, CRP and TC/HDL ratio. Copyright (c) 2007 S. Karger AG, Basel
