MTHFR, prothrombin and Factor V gene variants in Turkish patients with coronary artery stenosis

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dc.authorid0000-0001-5291-8620en_US
dc.contributor.authorCaner, Muege
dc.contributor.authorBircan, Rifat
dc.contributor.authorSevinc, Deniz
dc.contributor.authorBenli, Fehime
dc.contributor.authorGuney, A. Ilter
dc.contributor.authorKurtoglu, Nuri
dc.date.accessioned2024-07-12T21:47:08Z
dc.date.available2024-07-12T21:47:08Z
dc.date.issued2008en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractMany epidemiological studies have reported an association between hemostatic factors and risk of both coronary and peripheral artery diseases. Using polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) analysis, we investigated the association between coronary artery disease and polymorphisms in the methylenetetrahydrofolate reductase (MTHFR C677T and A1298C), prothrombin (G20210A), and factor V (A4070G) genes. We screened these gene variants in 174 subjects who had undergone coronary angiography - 115 patients with patent coronary artery disease (grade 3 vessel disease, i.e., significant coronary stenosis), and 59 healthy controls with grade 0 vessel disease. The analysis of our data did not show any statistically significant association between coronary artery disease (CAD) and the investigated polymorphisms.en_US
dc.identifier.doi10.1590/S1415-47572008005000023
dc.identifier.endpage838en_US
dc.identifier.issn1415-4757
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-62549138704en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage836en_US
dc.identifier.urihttps://dx.doi.org/10.1590/S1415-47572008005000023
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8011
dc.identifier.volume31en_US
dc.identifier.wosWOS:000261856700006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherSOC BRASIL GENETICAen_US
dc.relation.ispartofGENETICS AND MOLECULAR BIOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY01078
dc.subjectgenetic polymorphismen_US
dc.subjectcoronary diseaseen_US
dc.subjectMTHFR geneen_US
dc.subjectprothrombin geneen_US
dc.subjectFactor V geneen_US
dc.titleMTHFR, prothrombin and Factor V gene variants in Turkish patients with coronary artery stenosisen_US
dc.typeArticle
dspace.entity.typePublication

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