Investigation of the effect of radiotherapy on the proliferative index (Ki-67) in recurring diffuse glial tumors

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dc.contributor.authorMidi, A.
dc.contributor.authorBelirgen, M.
dc.contributor.authorÇag?lar, H.
dc.contributor.authorSav, A.
dc.date.accessioned2024-07-12T21:38:04Z
dc.date.available2024-07-12T21:38:04Z
dc.date.issued2011en_US
dc.department[Belirlenecek]en_US
dc.description.abstractIntroduction: Radiotherapy (RT) has various effects such as apoptosis stimulation, mitosis inhibition, mutagenic effect, chromosomal aberration and neoplastic transformation. Aim: The aim of this study was to investigate the effect of RT administered to diffuse glial tumors on the proliferation activity and mitotic activity of the tumor. Material-Method: An overall of 49 re-operated recurrent cases (16 cases had received postoperative RT while 33 cases did not receive RT) diagnosed as glial tumor were included in this study. The tumor cohort consisted of diffuse astrocytoma, oligodendroglioma and oligoastrocytomas. Ki-67 proliferating index, mitoses and grades of the primary and recurrent tumors were compared. Result: We found that the grades of recurrent tumors were lower than the grade during the first surgery in cases that had RT compared to those that had not. Similarly, Ki-67 was lower in cases that had received RT. We also noted suppressed mitotic activity in cases that had received RT.en_US
dc.identifier.endpage70en_US
dc.identifier.issn1300-1817
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-79953736623en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage65en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12415/7055
dc.identifier.volume28en_US
dc.indekslendigikaynakScopus
dc.language.isotren_US
dc.publisherEge University Pressen_US
dc.relation.ispartofJournal of Neurological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY04460
dc.subjectGlial Tumorsen_US
dc.subjectKi-67en_US
dc.subjectMitosisen_US
dc.subjectRadiotherapyen_US
dc.subjectRecurrent Tumorsen_US
dc.titleInvestigation of the effect of radiotherapy on the proliferative index (Ki-67) in recurring diffuse glial tumorsen_US
dc.typeArticle
dspace.entity.typePublication

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