Giant Cell Glioblastoma; Long-Term Survival, and Correlation With Usual Glioblastoma

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dc.authorid0000-0002-5947-947Xen_US
dc.authorid0000-0002-6197-7654en_US
dc.authorid0000-0002-7326-7801en_US
dc.contributor.authorMidi, Ahmet
dc.contributor.authorBelirgen, Muhittin
dc.contributor.authorSav, Aydin
dc.contributor.authorBozkurt, Suheyla
dc.contributor.authorMidi, Ipek
dc.contributor.authorKilic, Tuerker
dc.date.accessioned2024-07-12T21:51:01Z
dc.date.available2024-07-12T21:51:01Z
dc.date.issued2008en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractBackground: Giant cell glioblastoma (GCGB) is a rare tumor of the central nervous system and it accounts for only 1% of all intracranial tumors and 5% of glioblastomas. Objective: The aim of this study is to assess the histopathological and immunohistochemical findings and their correlation with survival time. Material-Method: We retrieved 23 consecutive GCGB specimens from a cohort of 650 glioblastoma cases and 24 usual glioblastoma cases with known survival information between 1995 and 2003. We used silver stain for reticulin framework, Ki-67, GFAP and CD45 as immunohistochemical stains. Results: GCGB accounts for 5% of all glioblastomas. The average survival is 31 and 16 months in GCGB and UGB respectively. There were significant differences between GCGB and UGB including the tumor infiltrating lymphocyte, perivascular lymphocyte, giant cell and oligodendroglia-like cells as histologic parameters. Presence of oligodendroglia-like cells was positively correlated with survival in GCGB. The parameters that were correlated with survival in UGB were younger age, high mitosis rate and a high Ki-67 proliferating index. Other parameters were not statistically significant in correlation with survival. Conclusion: GCGB had an overall longer survival rate than classical glioblastoma but the result was not statically significant.en_US
dc.identifier.endpage282en_US
dc.identifier.issn1302-1664
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-67650085844en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage272en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8232
dc.identifier.volume25en_US
dc.identifier.wosWOS:000264311800009en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherJOURNAL NEUROLOGICAL SCIENCESen_US
dc.relation.ispartofJOURNAL OF NEUROLOGICAL SCIENCES-TURKISHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY01984
dc.subjectGiant cell glioblastomaen_US
dc.subjectsurvivalen_US
dc.subjectimmunohistochemistryen_US
dc.subjectoligodendroglia-like cellen_US
dc.titleGiant Cell Glioblastoma; Long-Term Survival, and Correlation With Usual Glioblastomaen_US
dc.typeArticle
dspace.entity.typePublication

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