Western Diet and Cognitive Impairment: Links to Potential Mechanisms: A Review
Küçük Resim Yok
Tarih
2023
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Shiraz University of Medical Sciences
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Animal studies in recent years have shown that a Western diet style (WD-style) which is high in saturated fat and refined carbohydrates causes obesity, metabolic syndrome and cardiovascular diseases. In addition, results demonstrated that it can damage the structures that make up the nervous system. Accordingly, there is an evidence that systemic changes associated with the Western diet lead to blood-brain barrier (BBB) disruption, microglia activation, and the development of neuroinflammation. These changes are then followed by synaptic transmission dysfunction, neurodegeneration, and finally memory and cognitive deterioration. This review summarizes research on the mechanisms that show Western diet consumption is associated with cognitive impairment, with emphasis on learning and memory functions that depend on the integrity of the hippocampus. © 2023, Shiraz University of Medical Sciences. All rights reserved.
Açıklama
Anahtar Kelimeler
Cognitive Functions, Learning, Memory, Neuroinflammation, Western Diet
Kaynak
International Journal of Nutrition Sciences
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
8
Sayı
3
