Heterotrimeric G proteins

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dc.authorid0000-0003-2386-7646en_US
dc.contributor.authorKuecuekkaya, Bahire
dc.contributor.authorKan, Beki
dc.date.accessioned2024-07-12T21:58:20Z
dc.date.available2024-07-12T21:58:20Z
dc.date.issued2007en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractHeterotrimeric G proteins, commonly known as G proteins are members of the large GTPase superfamily that are conserved from bacteria to mammals. G proteins play an essential role in cellular signaling by coupling many cell surface receptors to effectors on the plasma membrane. G proteins are composed of an alpha-subunit that binds and hydrolyzes GTP and a beta gamma-subunit complex. To date over 20 different a subunits, 5 beta subunits and 14 gamma subtypes have been defined. Classification of G protein heterotrimers are based on the primary sequences of their alpha-subunits, resulting in four main families. In its inactive state, each G protein is a heterotimer in which the GDP bound alpha chain is tightly associated with the beta gamma subunits. Receptor activation promotes the replacement of GDP by GTP and the consequent dissociation of a from beta gamma. Both alpha GTP and the beta gamma complex interact with and regulate specific effectors. Activation is then terminated by the intrinsic GTPase activity of the a chain, which returns the protein to its inactive state. G proteins are regulated by posttranslational modifications including phosphorylation, myristoylation, palmitoylation, and prenylation of G alpha- and G beta gamma- subunits. G protein alpha- and beta gamma- subunits regulate the activities of diverse effectors. G proteins mediate a wide variety of cellular responses, including sensory perception, neuronal activity and hormonal regulation. Recent reports indicate that GPCRs and G proteins are also involved in the regulation of cell growth, differentiation and cellular transformation.en_US
dc.identifier.endpage50en_US
dc.identifier.issn0250-4685
dc.identifier.issn1303-829X
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage39en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8781
dc.identifier.volume32en_US
dc.identifier.wosWOS:000254852500007en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Science
dc.language.isotren_US
dc.publisherWALTER DE GRUYTER GMBHen_US
dc.relation.ispartofTURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISIen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY09302
dc.subjectHeterotrimeric G proteinsen_US
dc.subjectG proteinsen_US
dc.subjectcellular signalingen_US
dc.titleHeterotrimeric G proteinsen_US
dc.typeReview
dspace.entity.typePublication

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