Angiotensin-converting enzyme inhibitor captopril ameliorates renal damage in a rat model of thermal injury

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dc.authorid0000-0002-0021-8400en_US
dc.contributor.authorEmekli-Alturfan, Ebru
dc.contributor.authorOzdemir, Gulsen
dc.contributor.authorSaglam, Esra
dc.contributor.authorOzdamar, Emine Nur
dc.contributor.authorSehirli, Ozer
dc.contributor.authorSener, Goksel
dc.date.accessioned2024-07-12T21:45:09Z
dc.date.available2024-07-12T21:45:09Z
dc.date.issued2013en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractBackground: Burn is a posttraumatic inflammatory condition accompanied by both local and distant effects leading to intense inflammation, tissue damage, and infection. Acute renal failure is a well-known complication of severe burns and is an important factor leading to an increase in mortality. Objective: To determine the effect of captopril treatment on renal damage in a rat model of thermal injury by evaluating oxidant antioxidant system parameters, sialic acid levels, glutathione-S-transferase (GST), and tissue factor (TF) activities. Methods: Under ether anesthesia, the shaved dorsum of the rats was exposed to a 90 degrees C water bath for 10 seconds to induce burn injury. Captopril (1 mg/kg) or saline was administered intraperitoneally immediately after, and at 24 hours after burn injury. Rats were decapitated at 48 hours following the burn injury and trunk blood was collected to assay blood urea nitrogen (BUN) and creatinine concentrations. To evaluate the presence of oxidant injury, kidney tissue samples were taken to determine malondialdehyde (MDA), glutathione (GSH), sialic acid levels, and the activities of superoxide dismutase (SOD), catalase, GST, and TF. In the sham group the same protocol was applied except that the dorstun was dipped in a 25 degrees C water bath for 10 seconds. Results: Severe skin scald injury (30% of total body surface area) caused significant decreases in GSH level, SOD and catalase activities, and significant increases in TF and GST activities, and sialic acid levels. Treatment of rats with captopril (1mg/kg) significantly elevated the reduced GSH levels, SOD and catalase activities, while it decreased MDA, sialic acid levels, GST and TF activities. Conclusions: The present study showed for the first time that, captopril scavenging of reactive free radicals, normalizing the activities of TF and GST seems to be a promising agent for restoring renal damage following thermal trauma.en_US
dc.description.sponsorshipCommission of Scientific Investigations Projects of Marmara University [SAG-C-YLP-210311-0046]en_US
dc.description.sponsorshipThis study was supported by project number (SAG-C-YLP-210311-0046) from the Commission of Scientific Investigations Projects of Marmara University. All the authors declare that there is no conflict of interest in this work.en_US
dc.identifier.doi10.5372/1905-7415.0703.190
dc.identifier.endpage389en_US
dc.identifier.issn1905-7415
dc.identifier.issn1875-855X
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-84880693029en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage381en_US
dc.identifier.urihttps://dx.doi.org/10.5372/1905-7415.0703.190
dc.identifier.urihttps://hdl.handle.net/20.500.12415/7803
dc.identifier.volume7en_US
dc.identifier.wosWOS:000341273300012en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherWALTER DE GRUYTER GMBHen_US
dc.relation.ispartofASIAN BIOMEDICINEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY00349
dc.subjectBurnen_US
dc.subjectkidneyen_US
dc.subjectcaptoprilen_US
dc.subjectcatalaseen_US
dc.subjectglutathioneen_US
dc.subjectlipid peroxidationen_US
dc.subjectsialic aciden_US
dc.subjectsuperoxide dismutaseen_US
dc.subjecttissue factoren_US
dc.titleAngiotensin-converting enzyme inhibitor captopril ameliorates renal damage in a rat model of thermal injuryen_US
dc.typeArticle
dspace.entity.typePublication

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