Comparison of Melatonin Effect on Oxidant Status and Antioxidant Capacity in Liver and Heart of Young and Aged Rats

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dc.authorid0000-0001-6968-5472en_US
dc.contributor.authorGuney, Sevin
dc.contributor.authorCumaoglu, Ahmet
dc.contributor.authorOzturk, Guler
dc.contributor.authorAkbulut, K. Gonca
dc.contributor.authorKarasu, Cimen
dc.date.accessioned2024-07-12T21:49:50Z
dc.date.available2024-07-12T21:49:50Z
dc.date.issued2013en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractBackground: Oxidative stress is involved in several pathologic conditions such as metabolic or cardiovascular disease, and in aging. Oxidative damage of biomolecules increases with age. Melatonin is the main neurohormone of the pineal gland and specific antioxidants may act against age-related oxidative damage. Objective: This study investigated the effects of administration of melatonin on aging-related parameters such as total oxidant status (TOS), hydrogen peroxide (H2O2) and lipid hydroperoxide (LOOH) levels and total antioxidant capacity (TAC) in the heart and liver in a rat model of aging. Methods: Young (3-month-old) and aged (24-month-old) male Wistar rats were divided into control and melatonin-treated groups. Melatonin was given for 21 days (10 mg/kg/day). At the end of the treatment period, TOS, TAC, H2O2, and LOOH levels were measured. Results: H2O2 in the liver, but not in the heart, was found to be increased in aged rats. Melatonin treatment diminished H2O2 in the heart of both group of rats compared with those of untreated control rats. Melatonin treatment also led to a decrease in H2O2 in the liver of aged rats. LOOH were found to be increased in both tissues of aged rats whereas melatonin treatment decreased LOOH levels in heart and liver tissues of aged rats. In the young rats melatonin also inhibited LOOH in liver. TAC in heart and liver was not found to be statistically different between young and aged rats. In young rats, melatonin treatment resulted in an increase in TAC that was associated with increased H2O2. In the liver and heart of the rats, TOS was increased with age and was ameliorated by melatonin treatment. Conclusion: Our results demonstrate that there is no dramatic overall decline in the antioxidant system with age. However, total oxidant status increased with age. Melatonin has a restorative effect on oxidative status. Copyright (C) 2012, Taiwan Society of Geriatric Emergency & Critical Care Medicine. Published by Elsevier Taiwan LLC. All rights reserved.en_US
dc.identifier.doi10.1016/j.ijge.2012.11.010
dc.identifier.endpage49en_US
dc.identifier.issn1873-9598
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-84875278131en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage45en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.ijge.2012.11.010
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8094
dc.identifier.volume7en_US
dc.identifier.wosWOS:000317945800009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherELSEVIER TAIWANen_US
dc.relation.ispartofINTERNATIONAL JOURNAL OF GERONTOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY01292
dc.subjectagingen_US
dc.subjectantioxidanten_US
dc.subjectmelatoninen_US
dc.subjectoxidanten_US
dc.titleComparison of Melatonin Effect on Oxidant Status and Antioxidant Capacity in Liver and Heart of Young and Aged Ratsen_US
dc.typeArticle
dspace.entity.typePublication

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