Protective effects of glutathione administration on ischemia-reperfusion injury in rat ovaries

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dc.contributor.authorGürsoy, A.
dc.contributor.authorIpek, B.O.
dc.contributor.authorSade, A.G.
dc.contributor.authorAtasayan, K.
dc.contributor.authorDogan, Tekbaş E.
dc.contributor.authorSitar, M.E.
dc.date.accessioned2024-07-12T21:40:15Z
dc.date.available2024-07-12T21:40:15Z
dc.date.issued2023en_US
dc.department[Belirlenecek]en_US
dc.description.abstractWe aimed to examine the biochemical and histopathological potential beneficial effects of glutathione administration on the ovarian ischemia/reperfusion injury (IRI) model. Thirty Wistar Albino female rats were used in this experimental study and were divided into five groups. Group 1 (sham) underwent observational laparotomy. Group 2 (torsion) had their left ovaries torsioned. Group 3 (torsion + detorsion) was detorsioned after torsion. Groups 4 and 5 received the same procedure as group 3. 0,2 ml glutathione was applied to the left ovaries of group 4 (torsion + detorsion + intraovarian glutathione injection) after detorsion. Group 5 (torsion + detorsion + intraperitoneal glutathione injection) was administered 1 ml glutathione intraperitoneally five times. Fifteenth-day blood samples were taken to examine total antioxidant status, total oxidant status, oxidative stress index, anti-mullerian hormone (AMH), and malondialdehyde (MDA) values. Besides, the left ovaries were resected for histopathological examination. Total antioxidant status was significantly higher in the intraperitoneal injection group (p<0.05). The AMH values of the sham and intraovarian groups were similar (p>0.05). MDA value did not differ significantly between the sham, intraovarian, and intraperitoneal injection groups (p>0.05). In histopathological examination, no significant benefit of glutathione application on follicle numbers was shown. The main limitations of our study were the relatively small size of our series, the absence of serial blood measurement, the absence of a group in which intraovarian and intraperitoneal injections were administered together, and the absence of a sham + drug group. Glutathione administration reduces the detrimental effects of ovarian IRI. © 2023 Ondokuz Mayis Universitesi. All rights reserved.en_US
dc.description.sponsorship2019/09/04en_US
dc.description.sponsorshipThis study was funded by Maltepe University Scientific Investigation Projects Coordination Unit Maltepe University Animal Ethics Committee Approval Number: 2019/09/04en_US
dc.description.sponsorshipThis study was funded by Maltepe University Scientific Investigation Projects Coordination Uniten_US
dc.identifier.doi10.52142/omujecm.40.1.1
dc.identifier.endpage6en_US
dc.identifier.issn1309-4483
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85153521250en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.52142/omujecm.40.1.1
dc.identifier.urihttps://hdl.handle.net/20.500.12415/7204
dc.identifier.volume40en_US
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherOndokuz Mayis Universitesien_US
dc.relation.ispartofJournal of Experimental and Clinical Medicine (Turkey)en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY05114
dc.subjectAnti-Mullerian Hormoneen_US
dc.subjectGlutathioneen_US
dc.subjectIschemia Reperfusion Injuryen_US
dc.subjectOvarian Torsionen_US
dc.titleProtective effects of glutathione administration on ischemia-reperfusion injury in rat ovariesen_US
dc.typeArticle
dspace.entity.typePublication

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