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Yayın Association of prenatal, natal, and postnatal factors with maternal attachment(CUMHURIYET UNIV TIP FAK PSIKIYATRI ANABILIM DALI, 2015) Mutlu, Caner; Yorbik, Ozgur; Tanju, Ilhan Asya; Celikel, Fatih; Sezer, R. GonulObjective: The purpose of this study was to investigate the association of prenatal, natal and postnatal factors with maternal attachment in mothers having infants aged 1-4 months and defining no mental health problems. Methods: Information form, Symptom Checklist-90 (SCL-90) and Maternal Attachment Scale (MAS) were filled by mothers admitting to the pediatric clinics of two hospitals within six months, having infants aged 1-4 months, having birth records of their infants in one of these hospitals, having no previous psychiatric help for any reason, having no known psychiatric and/or chronic medical illness, being at least primary school graduates and agreeing to participate in the study (n=105). Associations of variables in the information form with scores of general symptom index (GSI) of the SCL-90 and MAS were evaluated. Results: Score of MBO of mothers having first baby was significantly higher compared to other mothers' scores. GSI score was significantly higher in mothers having a baby with undesired gender, compared to mothers having a baby with desired gender. There was no significant correlation between mother's age, length of marriage and the GSI score and MAS score. Conclusion: Having a baby for the first time, can be seen as one of the most important factors affecting attachment of mothers defining no mental health problems between the first and fourth months after birth. On the other hand, no difference found in almost all of prenatal, natal and postnatal factors in terms of maternal attachment suggests that maternal lovingly bonding process cannot be significantly affected by adverse conditions other than mental health problems.Yayın Effect of valproate on the plasma concentrations of aripiprazole in bipolar patients(INFORMA HEALTHCARE, 2014) Eryilmaz, Gul; Sayar, Gokben Hizli; Ozten, Eylem; Gul, Isil Gogcegoz; Karamustafalioglu, Oguz; Yorbik, OzgurObjective. There is very limited documentation available on the effects of valproate co-medication on the pharmacokinetics of aripiprazole in a naturalistic setting. The aim of the present study was to investigate the effect of co-medication with valproate on serum concentrations of aripiprazole in bipolar disorder patients in a clinical setting. Method. Plasma samples of bipolar disorder patients (n = 69) on a stable dose of aripiprazole 20 mg/day were analyzed by a liquid chromatography-mass spectrometry method in a routine therapeutic drug monitoring setting. Therapeutic drug monitoring was done for the entire study group before and aft er valproate co-administration. Results. We observed a statistically significant difference between the aripiprazole monotherapy and aripiprazole-valproate combination with respect to total aripiprazole plasma levels (p < 0.01). However, no statistically significant differences were noted in aripiprazole levels between the first week and the second week of valproate co-administration. Conclusion. In conclusion, concurrent treatment with valproate resulted in changes in the total aripiprazole plasma levels by 23%. But a lower total aripiprazole concentration during co-medication with valproate, caused by protein binding displacement, is reported being clinically insignificant in previous studies. The results from these studies are important in order to clarify clinical safety and efficacy.Yayın Frequencies of Allergic Diseases Among Children with Autism Spectrum Disorders(BILIMSEL TIP YAYINEVI, 2019) Akpinar, Fatma; Kutluk, Gunsel; Ozomay, Gulcan; Yorbik, Ozgur; Cetinkaya, FeyzullahObjective: Allergic diseases and autism spectrum disorders (ASD) affect millions of children worldwide and the frequencies of these diseases are increasing. Although some genetic and environmental factors have been implicated, the exact reasons of this increase have not been determined yet. In this study, we aimed to investigate the frequencies of allergic diseases among children with ASD. Materials and Methods: A questionnaire containing 23 questions related to asthma, allergic rhinitis, atopic dermatitis and food allergy adapted from the International Study of Asthma and Allergies in Childhood (ISAAC) was used and the questionnaires were filled out by the parents of children with ASD and controls. Results: The study and control groups comprised 59 and 50 children respectively. Allergic rhinitis was diagnosed in 12%, atopic dermatitis in 10.1%, food allergy in 8.4% and asthma in 6.8% of the children with ASD; and 16%, 6%, 8% and 10.0% respectively in the control group. Conclusion: These results suggest that frequency of allergic diseases among children with ASD are not different than controls.Yayın From Poster Presentation to Publication: National Congress of Child and Adolescent Psychiatry(AVES, 2015) Mutlu, Caner; Kaya Mutlu, Ebru; Kilicoglu, Ali Guven; Yorbik, OzgurIntroduction: The aims of this study were as follows: 1) to determine publication rate, time to publication, and study design of poster presentations accepted at the National Congress of Child and Adolescent Psychiatry (NCCAP) and converted to publication and the degree of first author in a published article and journal index and 2) to investigate the relationship of these data with each other. Methods: The poster presentations of four congresses organized between 2005 and 2008 were investigated separately. The presentations were screened by taking into account the title and the first and second author in English and Turkish languages via PubMed and Google Academic databases. Published studies, time between presentation and publishing date, study design, degree of first author, and journal index of these studies were recorded. Results: Fifty-four (25.2%) of 214 poster presentations were published in international and national peer-reviewed journals. Of the published articles, 74.1% (n=40) were research type and 61.1% (n=33) were found in the Science Citation Index (SCI) and Science Citation Index-Expanded (SCI-E) peer-reviewed journals. The first author in 42.6% (n=23) of published articles were assistant professors. The average time between presentation and publishing date was 30.72 +/- 18.89 months. Statistical differences were not determined between publication rate and study design; between time to publication and study type/study design, degree of first author, and journal index; and between journal index and study design and degree of first author (p>0.05). It was found that research articles were published significantly more by teaching staff than experts and other researchers (p<0.05). Conclusion: Compared with literature data, it was found that the time to publication was longer while the publication rate was similar for poster presentations in our congresses. Based on these results, it is important to create necessary conditions and encourage the researchers to publish the poster presentations presented in NCCAP.Yayın Possible Effects of Copper and Ceruloplasmin Levels on Auditory Event Potentials in Boys with Attention Deficit Hyperactivity Disorder(AVES, 2016) Yorbik, Ozgur; Mutlu, Caner; Ozdag, Mehmet Fatih; Olgun, Abdullah; Eryilmaz, Gul; Ayta, SemihIntroduction: The aims of the present study were to investigate the relationship between levels of plasma copper (Cu) and ceruloplasmin (Cp) and amplitudes and latencies of P1, N2, and P3 in the parietal and frontal areas of children with attention deficit hyperactivity disorder (ADHD) as well as to compare these Cu levels and event-related potentials (ERPs) indices in controls. Methods: Boys (n=41) with ADHD were divided into two subgroups according to a median split of plasma Cu and Cp levels, separately. ERP indices from the parietal and frontal regions were recorded in children with ADHD and 24 normal boys (control group) using an auditory oddball paradigm. Results: Parietal P3 latency was significantly longer, and parietal P3 amplitude, frontal P3 amplitude, and frontal N2 amplitudes were smaller in children with ADHD than in controls (all p values <0.017). Parietal P1 and frontal P1 latencies were significantly shorter in the higher Cu group than in the lower Cu group (both p values <0.017). Decreased latency of parietal P1 was dependent on plasma levels of Cu (p<0.05). Frontal N2 and parietal N2 amplitudes were significantly lower in the ADHD group with lower Cp levels than in the ADHD group with higher Cp levels (both p values <0.017). Decreased frontal N2 and parietal N2 amplitudes were dependent on plasma levels of Cp (both p values <0.05). Conclusion: Plasma Cu and Cp levels may have an effect on ERPs in ADHD, thus indicating the existence of effects on information processing. Cu levels may have a negative effect on the neuronal encoding of sound, whereas Cp levels may have a positive effect on the processes of cognitive control, conflict monitoring, and stimulus discrimination in children with ADHD.Yayın Possible negative effects of snoring and increased sleep fragmentation on developmental status of preschool children(WILEY-BLACKWELL, 2014) Yorbik, Ozgur; Mutlu, Caner; Koc, Derya; Mutluer, TubaLimited studies have investigated the effects of snoring although harmful neurocognitive effects of obstructive sleep apnea syndrome are relatively well known. The aim of the present study was to investigate the effects of snoring and fragmented sleep on mental development in preschool children. The study population consisted of 212 healthy preschool children (age range 3.1-6 years; mean = 5.4 +/- 0.6 years; 112 boys, 100 girls). The developmental status of the children was investigated by using the Ankara Developmental Screening Inventory (ADSI) and Peabody Picture Vocabulary Test (PBT). Children's sleep and snoring frequency were assessed by using parent completed Children's Sleep Habits Questionnaire (CSHQ). Snoring children had lower scores of language/cognitive skills, social/activities of daily living skills, and general development compared to controls (P < 0.05). The snoring group had more males, and more fragmented sleep than controls (P < 0.05). No significant difference was found in sleep duration between the snoring children and controls (P > 0.05). Children with fragmented sleep had lower scores of language/cognitive skills, fine motor skills, social/activities of daily living skills, and general development compared to controls (P < 0.05). In addition, no significant correlation was found between sleep duration and the developmental test scores (P > 0.05). Present study suggested that healthy preschool children who have habitual snoring or sleep fragmentation may have reduced scores of various mental development compared to controls. Uninterrupted sleep may be more important than sleep duration for the development of the various mental abilities in healthy preschool children. More studies investigating snoring and sleep fragmentation on mental development in children are warranted for a definite conclusion.Yayın Possible Predictors of Hospitalization for Adolescents with Conduct Disorder Seen in Psychiatric Emergency Service(YERKURE TANITIM & YAYINCILIK HIZMETLERI A S, 2015) Mutlu, Caner; Ozdemir, Melike; Yorbik, Ozgur; Kilicoglu, Ali GuvenPossible predictors of hospitalization for adolescents with conduct disorder seen in psychiatric emergency service Objective: The aim was to investigate predictors of hospitalization of adolescents with conduct disorder (CD) seen in emergency service of a mental health hospital. Method: Patients were evaluated retrospectively by age, gender, school status, family structure, presenting symptoms and their duration, comorbid psychiatric diagnoses, prior emergency service or outpatient clinic use, prior psychiatric hospitalization and family history of any mental disorder, according to first presentation during a 6-month period. Results: Mean age was 15.69 +/- 1.26 (12-17) years. Of the total of 144 patients, 61.8% (n=89) were female and 50 (34.7%) were hospitalized. Adolescents admitted to the inpatient unit presented significantly more often with suicidal ideation, had longer symptom duration, and were more likely to have a comorbid psychiatric disorder and a family history of a psychiatric disorder compared to those not admitted. In multivariate logistic regression analysis, suicidal ideation, having a comorbid psychiatric disorder, and having family history of a mental disorder predicted admission to the psychiatric inpatient unit. Conclusion: Clinicians in emergency settings should be aware of the prediction of hospitalization in adolescents with CD who have suicidal ideation, a comorbid psychiatric disorder and family history of a mental disorder. Suicide attempt seems to have an indirect effect, rather than a direct effect, on the prediction of hospitalization in youths with CD.Yayın Salivary alpha amylase levels in youths with anxiety disorders(ELSEVIER IRELAND LTD, 2016) Yorbik, Ozgur; Mutlu, Caner; Ozturk, Ozlem; Altinay, Derya Koc; Tanju, Ilhan Asya; Kurt, IsmailIt is suggested that salivary alpha-amylase (sAA) may be a marker of sympathoadrenal medullary system activity. Thus, it can be a possible relationship sAA and anxiety disorders. The aim of this study is to investigate sAA in children and adolescents with anxiety disorders and healthy controls. Thirty drug-free youths, aged 8-16 years, who were diagnosed as any anxiety disorders and 36 healthy controls with similar socio-demographic characteristics were included in this study. The sAA was found to be significantly increased in anxiety group compared to control group. However, there was no correlation between sAA and any anxiety scores of the scales. Present study suggested that anxiety disorders in youths may be associated with increased autonomic activity. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
