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Yayın Burkitt Lymphoma Like Nodular Diffuse Atypical Lymphoid Infiltration: A Case Report(Aves, 2013) Çelik, Öner; Atespare, Altay; Boyaci, Zerrin; Yener, Nese; Vural, ÇetinBurkitt's lymphoma is a type of B-cell lymphoma that grows rapidly and it usually localizes extranodally. Sometimes it occurs as leukemia-like infiltration. Lymph node involvement is rare. It has very high mitotic index. Starry sky view occurs as a result of phagocytosis of overproduced apoptotic cells by macrophages. Although it is a very fast growing tumor, cure can be achieved with intensive therapy. A twenty-six-year-old female patient presented to our clinic with a complaint of swelling in the neck. Fine needle aspiration biopsy was performed. Pre-diagnosis of the mass was atypical Burkitt's lymphoma. We agreed to perform excisional biopsy. In this paper we are presenting a rare case of 'Burkitt's lymphoma-like atypical diffuse lymphoid nodular-infiltration', finally diagnosed as a result of advanced hemato-pathologic analysis. Despite no oncological treatment, no recurrence occured in 1 year period of follow up.Yayın DUCTAL CARCINOMA INSITU SITUATED INSIDE A FIBROADENOMA: A CASE REPORT(Aves, 2012) Manukyan, Manuk Norayık; Deveci, Uğur; Kebudi, Abut; Midi, Ahmet; Yener, Nese; Çelik, LeventFibroadenomas are tumors consisting of a fibrous stroma without cytologic atypia and ductal carcinoma insitu is a malign epitelial proliferation limited within the breast ducts. A 21 years old patient was operated by her choice with the ultrasonographic diagnosis of a 27*16 mm fibroadenoma. The pahtological evaluation detected ductal carcinoma insitu situated inside the fibroadenoma. Some authorities prefer to enucleate the fibroadenomas while the others prefer a diagnostic biopsy and a long term follow up because fibroadenomas are usually detected in young women at ages that cancer is rarely diagnosed. Although ductal carcinoma insitu situated inside fibroadenomas has been reported before the treatment is controversial. Local excision with radiotherapy is the most popular choice. But in our case the ductal carcinoma insitu was totally inside the adenoma and regarding the side effects in such a young age radiotherapy was ommited. The follow up of the other fibroadenomas detected by magnetic resonance imaging is also contoversial.Yayın Gallstones and Concomitant Gastric Helicobacter pylori Infection(HINDAWI LTD, 2013) Attaallah, Wafi; Yener, Nese; Ugurlu, M. Umit; Manukyan, Manuk Norayık; Asmaz, Ebru; Aktan, A. OzdemirBackground. The association of gallstones with Helicobacter pylori has been investigated but not clearly demonstrated. In this study, the presence of H. pylori in the gallbladder mucosa of patients with symptomatic gallstones was investigated. Method. Ninety-four consecutive patients with symptomatic gallstone disease were enrolled for the study. Gastroscopy and gastric H. pylori urease test were done before cholecystectomy to all patients who accepted. After cholecystectomy, the gallbladder tissue was investigated in terms of H. pylori by urease test, Giemsa, and immunohistochemical stain. Results. Overall 35 patients (37%) gallbladder mucosa tested positive for H. pylori with any of the three tests. Correlation of the three tests Giemsa, IHC, and rapid urease test was significant (r(s): 0590, P > 0.001). Rapid urease test was positive in the gastricmucosa in 47 (58.7%) patients, and it was positive in the gallbladder mucosa in 21 patients (22%). In 15 patients both gastric and gallbladder tested positive with the urease test. There was significant correlation of rapid urease test in both of gallbladder and gastric mucosa (P = 0.0001). Conclusion. Study demonstrates the presence of H. pylori in the gallbladders of 37% of patients with symptomatic gallstones.Yayın Giant Tubular Adenoma of the Breast: A Rare Entity(WILEY-BLACKWELL, 2012) Dusunceli, Fikret; Manukyan, Manuk Norayık; Midi, Ahmet; Deveci, Uğur; Yener, Nese; Deveci, Uğur…Yayın MECHANICAL STIFFNESS OF PEGDA BASED HYDROGELS AFFECTS FORMATION OF HEPG2 SPHEROIDS IN 3D SCAFFOLDS(Wiley, 2021) Ulugöl, R. K.; Demirel, Gamze; Akbulut, Zeynep; Yener, Nese; Tok, Olgu Enis; Decker, Heather; Mellot, A. J.[Abstract Not Available]Yayın Melatonin with 1,25-Dihydroxyvitamin D3 Protects against Apoptotic Ischemia-Reperfusion Injury in the Rat Kidney(INFORMA HEALTHCARE, 2012) Sinanoglu, Orhun; Sezgin, Gulbuz; Ozturk, Guler; Tuncdemir, Matem; Guney, Sevin; Aksungar, Fehime Benli; Yener, NeseThis study was designed to evaluate the preventive role of melatonin (Mel) and 1,25-dihydroxyvitamin D3 (VD3) in biochemical and apoptotic events leading to tissue injury and renal dysfunction after ischemia-reperfusion (I/R). Thirty male Wistar rats were divided into five groups: sham-operated, I/R, Mel + I/R, VD3 + I/R, and Mel + VD3 + I/R. The rats were intraperitoneally administered with Mel (10 mg/kg), VD3 (0.5 mu g/kg), or Mel (10 mg/kg) plus VD3 (0.5 mu g/kg) each day at 1 week prior to ischemia. Right nephrectomy was initially performed and left renal I/R injury was induced by 45 min of bilateral renal ischemia followed by 45 min of reperfusion. After reperfusion, kidneys and blood were obtained for histopathologic and biochemical evaluation. Mel and VD3 had an ameliorative effect on biochemical parameters such as serum creatinine, blood urea nitrogen, alanine aminotransferase, aspartate aminotransferase, and apoptosis (caspase-3 and terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling staining) in the kidneys against renal I/R injury in rats. Additionally, VD3 combined with Mel significantly reduced apoptotic and histological alterations when compared with Mel or VD3 alone. This preventive effect on renal tubular apoptosis was remarkable when Mel was combined with VD3.Yayın Neurotoxic effects of levobupivacaine and fentanyl on rat spinal cord(ELSEVIER SCIENCE INC, 2015) Abut, Yesim Cokay; Turkmen, Asti Zengin; Midi, Ahmet; Eren, Burak; Yener, Nese; Nurten, AsiyeBackground: The purpose of the study was to compare the neurotoxic effects of intrathecally administered levobupivacaine, fentanyl and their mixture on rat spinal cord. Methods: In experiment, there were four groups with medication and a control group. Rats were injected 15 mu L saline or fentanyl 0.0005 mu g/15 mu L, levobupivacaine 0.25%/15 mu L and fentanyl 0.0005 mu g + levobupivacaine 0.25%/15 mu L intrathecally for four days. Hot plate test was performed to assess neurologic function after each injection at 5th, 30th and 60th min. Five days after last lumbal injection, spinal cord sections between the T5 and T6 vertebral levels were obtained for histologic analysis. A score based on subjective assessment of number of eosinophilic neurons - Red neuron - which means irreversible neuronal degeneration. They reflect the approximate number of degenerating neurons present in the affected neuroanatomic areas as follows: 1, none; 2, 1-20%; 3, 21-40%; 4, 41-60%; and 5, 61-100% dead neurons. An overall neuropathologic score was calculated for each rat by summating the pathologic scores for all spinal cord areas examined. Results: In the results of HPT, comparing the control group, analgesic latency statistically prolonged for all four groups. In neuropathologic investment, the fentanyl and fentanyl + levobupivacaine groups have statistically significant high degenerative neuron counts than control and saline groups. Conclusions: These results suggest that, when administered intrathecally in rats, fentanyl and levobupivacaine behave similar for analgesic action, but fentanyl may be neurotoxic for spinal cord. There was no significant degeneration with levobupivacaine, but fentanyl group has had significant degeneration. (C) 2013 Sociedade Brasileira de Anestesiologia. Published by Elsevier Editora Ltda. All rights reserved.Yayın Solitary Cerebellar Metastasis from a non-muscle Invasive Transitional Cell Carcinoma of Bladder(JOURNAL NEUROLOGICAL SCIENCES, 2015) Kelten, Bilal; Ekici, Sinan; Erdogan, Hakan; Sinanoglu, Orhun; Yener, Nese; Karaoglan, AlperBrain metastasis from non muscle invasive transitional cell carcinoma of the urinary bladder occurs very rarely. Herein, a patient who underwent transurethral resection of bladder tumor and received intravesical bacillus Calmette- Guerin for pT1, G3 bladder carcinoma accompanied by carcinoma in situ, and who subsequently developed solitary cerebellar metastasis following 18 months cystoscopic follow-up period with normal findings was reported. To our knowledge, only two cases of solitary cerebellar metastasis from pT1 bladder cancer was reported in the English literature.Yayın Vacuum-assisted stereotactic biopsy for isolated BI-RADS 4 microcalcifications: evaluation with histopathology and midterm follow-up results(AVES, 2015) Atasoy, Mehmet Mahir; Tasali, Nuri; Cubuk, Rahmi; Narin, Burcu; Deveci, Uğur; Yener, Nese; Celik, Levent; Deveci, UğurPURPOSE The aim of this study was to evaluate the 10-gauge vacuum-assisted stereotactic biopsy (VASB) of isolated Breast Imaging Reporting and Data System (BI-RADS) 4 microcalcifications, using histology and follow-up results. METHODS From January 2011 to June 2013, VASB was performed on 132 lesions, and 66 microcalcification-only lesions of BI-RADS 4 were included into our study. VASB was performed using lateral decubitis stereotaxy for all patients. Pathologic results of VASB and further surgical biopsies were reviewed retrospectively. Patients who were diagnosed to have benign lesions by VASB were referred for follow-up. VASB and surgical histopathology results were compared to determine the underestimation ratios. RESULTS Fifteen out of 66 lesions from 63 patients (median age, 47 years; range, 34-88 years) were identified as malignant by VASB. Pathological results after surgery revealed three cases of invasive ductal carcinoma among the 12 VASB-diagnosed ductal carcinoma in situ (DCIS) lesions, for a DCIS underestimation rate of 25%. The atypical ductal hyperplasia underestimation rate was 0% for the three lesions. The follow-up period was at least 10 months, with an average of 22.7 months for all patients and 21.2 months for patients with VASB-diagnosed benign lesions. None of the patients had malignancy during the follow-ups. The false-negative rate was 0% in the follow-up of 48 patients. CONCLUSION VASB should be the standard method of choice for BI-RADS 4 microcalcifications. This method obviates the need for a surgical procedure in 73% of BI-RADS 4 microcalcification-only patients.Yayın Xanthogranulomatous salpingitis as a rare pathologic aspect of chronic active pelvic inflammatory disease(MEDKNOW PUBLICATIONS, 2011) Yener, Nese; Ilter, Erdin; Midi, AhmetXanthogranulomatous salpingitis (XGS) is a rare form of chronic inflammation of the fallopian tubes. A 41-year old woman with a history of secondary infertility for 2 years is presented. The patient underwent bilateral salpingooopherectomy with presumptive diagnosis of adnexal mass with cystic component. Intraoperative pathology consultation was done. The diagnosis of bilateral XGS associated with chronic active follicular salpingitis was made. XGS is reported to be caused by an unsuccesfully treated pelvic inflammatory disease. Its association with chronic active follicular salpingitis has not been previously reported. Chronic active follicular salpingitis with xanthogranulomatous inflammation might give the impression of a cystic adnexal mass with septations on preoperative pelvic computed tomography. Frozen sections are necessary to rule out malignancy as done in our case.
