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Yayın Are increased carotid artery pulsatility and resistance indexes early signs of vascular abnormalities in young obese males?(WILEY-BLACKWELL, 2012) Ozari, H. Onur; Oktenli, Cagatay; Celik, Serkan; Tangi, Fatih; Ipcioglu, Osman; Terekeci, Hakan M.; Top, Cihan; Uzun, Mehmet; Sanisoglu, Yavuz S.; Nalbant, SelimPurpose: To provide insight into the factors by which obesity in itself may directly lead to early arterial damage, we aimed to determine early sonographic markers of obesity-related vascular dysfunction in young obese males. Methods: Thirty-five young obese males and 23 age-matched healthy male volunteers were recruited into the study. Common carotid artery pulsatility index and resistance index were calculated from blood flow velocities curves obtained by pulsed Doppler ultrasonography. Results: The mean pulsatility index, resistance index, body mass index, waist circumference, systolic and diastolic blood pressure, homeostasis model assessment for insulin resistance, plasma fasting glucose, insulin, C-peptide, triglycerides, low-density lipoprotein cholesterol, and high-sensitivity C-reactive protein were statistically higher in obese subjects than in healthy controls. Conclusions: Our results suggest that depressed vessel compliance and increased vascular resistance are features of young, obese, normotensive subjects independently of and in addition to cardiovascular risk factors. As changes in arterial wall properties may be incipient in young obese subjects, future studies will be required to demonstrate whether early intervention such as diet and exercise in this population can improve vascular functions. (C) 2012 Wiley Periodicals, Inc. J Clin Ultrasound, 2012Yayın Brakiyal arter intima-media kalınlığı/Brakiyal arter intima-media kalınlığının endotel fonksiyonu ve sol ventrikül kütle indeksi ile ilişkisi(KARE Publishing, 2010) Yiğiner, Ömer; Işılak, Zafer; Uz, Ömer; Uzun, MehmetAnadolu Kardiyoloji Dergisi Haziran 2010 sayisinda yayinlanan "Brakiyal Arter Intima Media Kalinliginin Endotel Fonksiyonu ve Sol ventrikül Kütle Indeksi ile Iliskisi" baslikli makalemize gösterdigi ilgiden ve tamamlayici elestirilerinden dolayi sayin meslektaslarima tesekkür ederim. Ölçümlerin hangi koldan yapildigi sorulmustur. Çalismamizda tüm olgularda, brakiyal arter intima-media kalinligi (IMK) ve akim aracili vazodilatasyon (FMD) için tüm ölçümler, ultrasonografi cihazi ve sedye yerlesimi açisindan ölçüm almaya daha uygun oldugu için, sag koldan alindi. Yayinimizda ölçümlerin hangi koldan yapildigi açikça belirtilmediginden, bu duruma açiklik getirme firsati verdigi için bir kez daha yazarlara tesekkür ederim. Sag ve sol brakiyal IMK arasinda anlamli fark olup olmayacagi çalismalarla ortaya konmasi gerekmektedir. Gerçekten bu konuyu arastiran bir çalisma ilgi çekecektir.Yayın Effects of patient education and counseling about life style on quality of life in patients with coronary artery disease(Turkish Society of Cardiology, 2011) Işılak, Zafer; Tokatlı, Alptuğ; Uzun, MehmetEffects of patient education and counseling about life style on quality of life in patients with coronary artery diseaseYayın Hiperlipidemi tanımı(Türkiye Klinikleri, 2012) Yalçın, Murat; Uzun, Mehmetperlipidemi, kullanım amacına uygun olarak yapılan çeşitli karşılaştırmalara göre kullanılan bir terimdir. Kan lipidlerinin toplum ortalamasından yüksek olması, çeşitli hastalıklar için risk etmeni olması, maliyet-etkin tedavi sağlanan alt sınır değerlerden daha yüksek olması gibi çeşitli tanımlama yöntemleri vardır. Bu yazıda, bu yöntemlere, kısaca lipid metabolizmasına ve hiperlipidemilerin sınıflandırılmasına değinilmiştir.Yayın Kardiyak rehabilitasyon ve kardiyopulmoner egzersiz testi(Türkiye Klinikleri, 2012) Uzun, Mehmet; Yalçın, Murat; Işılak, ZaferKardiyopulmoner egzersiz testi, kardiyolojide gittikçe artan sıklıkta kullanılan, noninvaziv bir testtir. Egzersiz intoleransının değerlendirilmesinde ve ayırıcı tanısında altın standart yöntemdir. Temel kullanım alanlarından biri de kalp hastalıklarının tanı, tedavi ve takibidir. Kalp hastalıklarında tanıya katkısı bu yazının kapsamı dışında tutulmuş, tedavi ve takibin en önemli unsurlarından biri olan kardiyak rehabilitasyondaki kullanımına ve prognostik değerine değinilmiştir.Yayın Perindopril, atenolol, and amlodipine prevent aortic ultrastructural changes in rats exposed to ethanol(International Scientific Information, 2008) Yokuşoğlu, Mehmet; Sağ, Cemal; Uzun, Mehmet; Kayır, Hakan; Köz, Cem; Baykal, Barış; Özkan, Mustafa; Özoğul, Candan; Baysan, Oben; Uzbay, İsmail TayfunBackground: The effects of perindopril, an angiotensin-converting enzyme inhibitor, atenolol, a beta adrenergic receptor blocker, and amlodipine, a calcium channel blocker, were investigated in chronic alcohol administered rats. Material/methods: Adult male Wistar rats (240-320 g) were used in the present study. Alcohol was given to rats on a modified liquid diet for 21 days. Perindopril (2.5 and 5 mg/kg), atenolol (5 and 10 mg/kg), and amlodipine (5 and 10 mg/kg) were injected into rats in different groups intraperitoneally for 21 days. Control rats were pair fed an isocaloric liquid diet containing sucrose as a caloric substitute for alcohol. Saline was injected into the control rats for 21 days. The hearts were removed after the rats were anesthetized by ether, and 1-mm3 samples from the ascending aortas were fixed. Five fields per aorta were examined and photographed with a transmission electron microscope. Blood alcohol levels were also measured spectrophotometrically. Results: Daily alcohol consumption of the rats was in the range of 12.09-15.50 g/kg. Blood alcohol concentrations were 145.63 mg/dl on the 21st day of alcohol consumption. Chronic alcohol consumption caused some marked aortic wall injuries. Perindopril, atenolol, and amlodipine at high doses, but not low doses, produced some significant beneficial effects on alcohol-induced aortic wall damage. Conclusions: These results imply that perindopril, atenolol, and amlodipine may have protective effects on heavy chronic alcohol consumption-induced aortic wall injury in rats only in high doses.Yayın The prevention of myocardial ultrastructural changes by perindopril, atenolol and amlodipine in chronic alcohol administered rats(Elsevier, 2006) Sağ, Cemal; Yokuşoğlu, Mehmet; Özkan, Mustafa; Kayır, Hakan; Uzun, Mehmet; Baykal, Barış; Özoğul, Candan; Baysan, Oben; Uzbay, TayfunThe effects of perindopril, an angiotensin converting enzyme inhibitor, atenolol, a beta adrenergic receptor blocker and amlodipine, a calcium channel blocker were investigated in chronic alcohol administered rats. Adult male Wistar rats (240–320 g) were used in the present study. Alcohol was given to rats by a modified liquid diet for 21 days. Perindopril (2.5 and 5 mg kg?1), atenolol (5 and 10 mg kg?1) and amlodipine (5 and 10 mg kg?1) were injected to rats in different groups intraperitoneally for 21 days. Control rats were pair fed by an isocaloric liquid diet containing sucrose as a caloric substitute for alcohol. Saline was injected to control rats for 21 days. Rats were anesthetized with ether. Their hearts were removed and 1 mm3 samples from left ventricles were fixed. Five fields per heart were examined and photographed with transmission electron microscope. Blood alcohol levels were also measured spectrophotometrically. Daily alcohol consumption of the rats was in a range of 12.09–15.5 g kg?1. Blood alcohol concentrations were found as 145.63 mg dl?1 at 21st day of alcohol consumption. Chronic alcohol consumption caused some marked myocardial injuries. Perindopril and atenolol but not amlodipine produced some significant beneficial effects on alcohol-induced myocardial damages. Our results imply that perindopril and atenolol but not amlodipine have protective effects on heavy chronic alcohol consumption-induced myocardial injury in rats.Yayın A simplified proximal isovelocity surface area method for mitral valve area calculation in mitral stenosis: not requiring angle correction and calculator(DOAJ, 2011) Yiğiner, Ömer; Uzun, Mehmet; Kardeşoğlu, Ejder; Atalay, Murat; Işılak, Zafer; Uz, Ömer; Keser, Nurgül; Cebeci, Bekir SıtkıAim: To simplify proximal isovelocity surface area (PISA) method for mitral valve area (MVA) calculation that does not necessitate the usage of a calculator and angle correction, and to compare values estimated using this novel method with the values obtained by the conventional PISA, planimetry and pressure half-time (PHT) methods. Methods: We evaluated patients with a wide range of mitral stenosis (MS) severity. The MVA was measured by the methods of PHT (MVA PHT), planimetry (MVApl), conventional PISA (MVAC-PISA) and the novel method of simple PISA (MVAS-PISA). Application of simple PISA was performed subsequently by division of the peak mitral inflow velocity by four; measurement of the radius by adjusting the aliasing velocity to this value; square of the radius gives the MVAS-PISA. Results: Twenty patients were enrolled in the study. Peak and mean pressure gradients of patients were 20 ± 6 mmHg and 10 ± 4 mmHg, respectively. The average values of MVApl, MVAPHT, MVAC-PISA, and MVA S-PISA were 1,54 ± 0,41, 1,65 ± 0,40, 1,58 ± 0,42, 1,57 ± 0,44 cm2, respectively. MVAS-PISA had a strong correlation with the MVAC-PISA, MVApl and MVAPHT . Furthermore, there was no significant difference between simple PISA and the other methods. The agreement between planimetry and simple PISA methods for detecting severe mitral stenosis (MVA <1.5 cm2) determined by ROC analysis was very good with a sensitivity and specificity of 100 % and 92%, respectively. Conclusions: Simple PISA is a user friendly method which does not take time and gives simple and correct results. If the diagnostic power of the technique is proven by more comprehensive studies, it can supersede the conventional PISA method.
