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Yayın Comparison of Two Different Ultrasound Methods of Phacoemulsification(ELSEVIER SCIENCE INC, 2014) Helvacioglu, Firat; Yeter, Celal; Sencan, Sadik; Tunc, Zeki; Uyar, O. MuratPURPOSE: To compare the safety and efficacy of micro-coaxial phacoemulsification surgeries performed with the OZil Intelligent Phaco torsional mode (Alcon Laboratories, Inc., Fort Worth, USA) and combined torsional/longitudinal ultrasound mode using 45 degree aperture angled tips. DESIGN: Prospective randomized clinical trial. METHODS: SETTING: Maltepe University, Istanbul. PATIENT POPULATION: Eighty eyes of 80 cataract patients were randomly assigned to 2.2 mm microcowdal phacoemulsification using the OZil Intelligent Phaco torsional mode (Group 1) or combined torsional/longitudinal ultrasound mode (Group 2). OBSERVATION PROCEDURE: Intraoperative fluid and energy usage and postoperative examinations were evaluated. MAIN OUTCOME MEASURES: Ultrasound time, cumulative dissipated energy, longitudinal and torsional ultrasound amplitudes, mean operation time, mean volume of fluid used, and surgical complications. RESULTS: Both groups included 40 eyes. Mean ultrasound time, cumulative dissipated energy, and longitudinal and torsional ultrasound amplitudes in Group 1 were 58.21 +/- 33.81 seconds, 7.74 +/- 6.23, 0.45 +/- 0.30, and 26.30 +/- 12.60%, respectively, and these parameters in Group 2 were 64.75 +/- 30.23 seconds, 12.61 +/- 6.21, 26.32 +/- 5.85, and 40.98 +/- 8.33%, respectively. Cumulative dissipated energy and longitudinal and torsional amplitudes were found to be significantly lower in Group 1 (P = .001, P < .001, P < .001). Mean volumes of fluid used in Groups 1 and 2 were 73.30 +/- 19.87 cc and 107.07 +/- 21.82 cc, respectively (P < .001). CONCLUSION: With the aid of a 45 degree aperture angled tip, the OZil Intelligent Phaco torsional mode provided more effective lens removal than the combined torsional/longitudinal ultrasound mode, with a lower cumulative dissipated energy and volume of fluid used. (C) 2014 by Elsevier Inc. All rights reserved.Yayın Hemorrhagic Age-Related Macular Degeneration Managed With Vitrectomy, Subretinal Injection of Tissue Plasminogen Activator, Gas Tamponade, and Upright Positioning(SLACK INC, 2013) Kapran, Ziya; Ozkaya, Abdullah; Uyar, O. MuratBACKGROUND AND OBJECTIVE: To investigate the outcomes of vitrectomy, subretinal tissue plasminogen (tPA) injection, gas tamponade, and upright positioning in patients with hemorrhagic neovascular age-related macular degeneration (AMD). PATIENTS AND METHODS: Retrospective, noncomparative case series. Records of patients who were diagnosed with submacular hemorrhage secondary to neovascular AMD and underwent treatment with the combined method between 2004 and 2010 were reviewed. The main outcome measure was the difference between preoperative and postoperative best corrected visual acuity (BCVA). RESULTS: In 10 eyes of 10 patients, mean preoperative and postoperative BCVA values were 1.75 and 1.23 logMAR, respectively (P = .011), after a mean follow-up time of 38.7 +/- 26.5 months (range: 10 to 71 months). Eight of 10 patients (80%) gained at least three lines. CONCLUSION: In patients with hemorrhagic neovascular AMD, treatment with vitrectomy, subretinal tPA injection, gas tamponade, and upright positioning was associated with better visual outcomes than those reported for patients with untreated disease.Yayın Outcomes of torsional microcoaxial phacoemulsification using tips with 30-degree and 45-degree aperture angles(ELSEVIER SCIENCE INC, 2014) Helvacioglu, Firat; Sencan, Sadik; Yeter, Celal; Tunc, Zeki; Uyar, O. MuratPURPOSE: To compare the safety and efficacy of Ozil Intelligent Phaco torsional microcoaxial phacoemulsification surgeries performed using 30-degree and 45-degree aperture angled tips. SETTING: Maltepe University School of Medicine Department of Ophthalmology, Istanbul, Turkey. DESIGN: Comparative case series. METHODS: Eyes were assigned to 2.2 mm microcoaxial phacoemulsification using the torsional mode with a 45-degree (Group 1) or 30-degree (Group 2) aperture angled tip. A quick-chop surgical technique was used. The primary outcome measures were ultrasound time (UST), cumulative dissipated energy (CDE), longitudinal and torsional ultrasound (US) amplitudes, mean surgical time, mean balanced salt solution volume used, and mean central corneal thickness (CCT) changes. RESULTS: The mean UST, CDE, and longitudinal and torsional US amplitudes were 58.21 seconds +/- 33.81 (SD), 7.74 +/- 6.23, 0.45 +/- 0.30, and 26.30 +/- 12.60 in Group 1 and 63.83 +/- 23.42 seconds, 12.36 +/- 6.75, 0.23 +/- 0.26, and 44.65 +/- 14.38 in Group 2, respectively. The mean CDE and torsional amplitudes were significantly lower in Group 1 (P=.002 and P=.001, respectively). The mean balanced salt solution volume was 73.30 +/- 19.87 cc in Group 1 and 74.30 +/- 19.44 cc in Group 2 (P=.821). The mean CCT change was 52.40 +/- 38.08 mu m and 99.35 +/- 47.14 mu m, respectively (P<.001). CONCLUSION: Torsional phacoemulsification performed with a 45-degree aperture angled tip provided more effective lens removal with a lower CDE and less CCT change than a 30-degree aperture angled tip.Yayın Travmatik ve İyatrojenik Koroid Neovaskülarizasyonları(2017) Uyar, O. MuratTravmatik koroid neovaskülarizasyonu (KNV) patogenezinde özellikle künt travmalar sonucu gelişen koroid rüptürleri önemli rol oynamaktadır. Angioid streaks (AS) gibi Bruch membranı (BM) daha kırılgan olgularda KNV gelişimi daha fazla görülmektedir. Yaşa bağlı yaş tip makula dejenerasyonundan (YBMD) çeşitli farkları olmasına rağmen tanı yöntemleri ve günümüze kadar uygulanan tedavileri benzerlik göstermektedir. Rüptürün yeri ve büyüklüğüne göre değişmekle birlikte, travma olgularının görece daha genç oluşu, eşlik eden kronik hastalıkların azlığı, KNV'lerin küçüklüğü, subfoveal yerleşimin daha az oluşu, RPE düzeyindeki çeşitli rejeneratif mekanizmalar nedeniyle prognoz daha iyidir. Tedavide son on yıla kadar termal lazer, fotodinamik tedavi, besleyici damarın fotokoagülasyonu ve koroidal neovasküler membran (KNVM) eksizyonu uygulanmışken günümüzde intravitreal antiVGEFler ile daha iyi ve uzun süreli cevap alınmaktadır. Ancak AS olgularında daha sık enjeksiyonlar gerekebilmektedir.İyatrojenik KNV'ler ise çoğunlukla termal lazerlerin yüksek doz ve düşük spot çapında uygulanmaları sonucu ve daha nadir olarak da çeşitli oküler cerrahilere bağlı olarak bildirilmiştir. Ülkemizde başta iş ve trafik kazaları olmak üzere travma nedenlerine karşı alınacak önlemler büyük önem taşımaktadır. Özellikle lazer ve makula cerrahileri başta olmak üzere branş uzmanlık eğitimi ile dikkat ve özenin üst düzeyde olması da iyatrojenik KNV riskini azaltacaktır. Çeşitli faktörler, moleküller ve gen transferleri ile yapılmakta olan deneysel hayvan çalışmaları da patogenez ve tedavi açısından umut vericidir