Yazar "Us, MH" seçeneğine göre listele

Listeleniyor 1 - 3 / 3
  • Küçük Resim Yok
    Yayın
    Coronary artery bypass grafting alone - for advanced ischemic left ventricular dysfunction with significant mitral regurgitation: Early and midterm outcomes in a small series
    (Texas Heart Inst, 2004) Ogus, NT; Us, MH; Ogus, H; Isik, O
    In 31 consecutive patients with ischemic left ventricular dysfunction and mitral regurgitation ranging from 2/4 to 3/4 (mean, 2.87 +/- 0.34), we performed coronary bypass grafting alone and assessed early and midterm outcomes. Our patients' mean preoperative New York Heart Association functional class was 3.64 +/- 0.48, and their mean left ventricular ejection fraction was 0.25 +/- 0.05. Preoperative thallium imaging revealed that all patients had at minimum a partially reversible defect in the anterior wall. All patients survived the operation. Hospital length of stay ranged from 5 to 21 days (mean, 8.35 +/- 4.07 days), and mean length of follow-up was 21.35 +/- 13.24 months. Postoperatively, patients' functional classification improved to a mean of 1.32 +/- 0.6; left ventricular ejection fraction improved to a mean of 0.43 +/- 0.09; and severity of mitral regurgitation decreased to a mean of 1.35 +/- 0.96. Statistical analysis showed that all improvements were significant. Five late cardiac deaths occurred. Preoperative variables showed no correlation with late death. However postoperative left ventricular ejection fraction and mitral regurgitation did correlate with late death, which suggests that the reversibility of damaged ischemic myocardium plays an important role after revascularization. This study supports the concept that ischemic mitral regurgitation might well improve after myocardial revascularization regardless of its severity; therefore, it should not be corrected at the primary operation, except in patients with organic valvular changes.
  • Küçük Resim Yok
    Yayın
    Reperfusion strategy after regional ischaemia: Simulation of emergency revascularization and effects of integrated cardioplegia on myocardial resuscitation
    (SAGE PUBLICATIONS LTD, 2004) Us, MH; Ogus, NT; Yildirim, T; Ogus, H; Ozkan, S; Ozturk, OY; Isik, O
    We induced ischaemia in the left anterior descending artery of 16 dogs while the heart was beating, followed by cardiopulmonary bypass (CPB), aortic cross clamping and blood cardioplegia. Half of the dogs received integrated blood cardioplegia and sudden uncontrolled reperfusion (group A) while the others received the same cardioplegia followed by pressure-controlled tepid initial reperfusion (group B). The effects on myocardial cell metabolism, oxidative stress and ultrastructure were recorded. The recovery period was significantly longer and cardiac output levels after CPB significantly lower in group A compared with group B. Group A showed a failure to uptake and utilize oxygen during the recovery period and significant lipid peroxidation. Marked tissue oedema was seen in group A but mitochondrial and organelle integrity was almost normal in both groups. We conclude that integrated cardioplegia could partially resuscitate the myocardium in this model, and pressure controlled reperfusion during the first 2 min is needed as an adjunct procedure.
  • Küçük Resim Yok
    Yayın
    Sternal cyanoacrylate gluing in mediastinitis - Effects on infection, stability and bone healing
    (EDIZIONI MINERVA MEDICA, 2002) Ogus, TN; Us, MH; Cicek, S; Ozkan, S; Ozturk, OY; Isic, O
    Background It is crucial to determine stability, histocompatibility and antibacterial properties of the cyanoacrylate used for sternal fixation. Methods. Clinical study: in 17 cases of mediastinitis, debridement and rewiring the sternum, was applied as the treatment method (Group I). Eighteen cases of mediastinitis were treated with the same method added sternal cyanoacrylate gluing (Group 11). A comparative study was done;, the follow-up period was 36.7 +/- 4 and 18.5 +/- 6.9 months in Group I and H, respectively. Animal study: in 10 rats, upper sternotomy was done and the sternal bone was contaminated. Direct wound closure was done in 4 rats (Group A), in 6 animals, wounds were dosed after applying cyanoacrylate in sternal split (Group B). in this prospective study, all rats alive were sacrificed at the 3rd and 8th weeks and sternums were examined histologically. Results. Clinical study: in Group 1, 6 patients required additional interventions due to recurrent sternal detachment and osteomyelitis (35.3%). In Group H neither osteomyelitis nor sternal detachment occurred, 3 patients required re-intervention related to cyanoacrylate histotoxicity. Hospital stay was higher in Group I than Group II (24.06 +/- 4.7 vs 14.16 +/- 3.98 days, respectively). Experimental study: all of the animals in Group A died of sepsis. In Group B all rats survived the procedure. At the 3rd week histologic evaluations showed that cyanoacrylate was not degraded, and no infection or foreign body reaction was observed. At the 8th week histologic examination showed that cyanoacrylate was completely degraded and replaced by connective tissue. Conclusions. Cyanoacrylate is effective in diminishing sternal wound complications and related cost and hospital stay of mediastinitis.