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    Effect of sertindole on QTc interval in patients with schizophrenia
    (ELSEVIER IRELAND LTD, 2008) Atmaca, Murad; Yavuzkir, Mustafa; Mermi, Osman; Topuz, Mehtap; Kanmaz, Ebru; Tezcan, Ertan
    Sertindole has been marketed and offered daily clinical practice only for 9 months in our country, so no data has been its QTc prolongation potential. In the present study, we performed a clinical trial to investigate the effects of sertindole on QTc in patients with schizophrenia. The study comprised 21 patients with schizophrenia. Sertindole was administered in the following dosing regime: treatment was initiated with 4 mg/day sertindole. From day 3 to day 6, the dose was increased to 8 mg/day, and up to day 9, it was raised to 12 mg/day. The protocol allowed up to dose of 20 mg/day according to effectiveness and tolerability. QTc values were determined at beginning, months 3 and 6. In addition, Positive and Negative Syndrome Scale (PANSS) were scored concomitantly. At the beginning of 6-month period, the mean QTc interval of patients was 391.7 +/- 19.2 ms. At the end of this period, it was 402.8 +/- 23.8 ms. Although the mean QTc interval changing was significant throughout 6-month period, of the patients, at any evaluation point, only 1 female (451 ms) and 1 male (433 ms) had borderline prolongation at month 3 for both, without any exceeding the dangerous limits. In summary, our results suggest that sertindole is tolerable and despite dose-related QT prolongation, sertindole had not the proarrhythmic profile. Future studies with larger sample evaluating the effects of treatment are required. (c) 2008 Published by Elsevier Ireland Ltd.
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    Hippocampus and amygdalar volumes in patients with refractory obsessive-compulsive disorder
    (PERGAMON-ELSEVIER SCIENCE LTD, 2008) Atmaca, Murad; Yildirim, Hanefi; Ozdemir, Huseyin; Ozler, Sinan; Kara, Bilge; Ozler, Zuhal; Kanmaz, Ebru; Mermi, Osman; Tezcan, Ertan
    Functional and structural neuroimaging studies have implicated the hippocampus-amygdala complex in the pathophysiology of obsessive-compulsive disorder (OCD), although no consensus has been established. These brain regions have not been investigated in refractory OCD patients. Volumes of the hippocampus, and amygdala were measured by magnetic resonance imaging (MRI) in a sample of 14 refractory OCD patients and 14 healthy comparison subjects. The mean left and right hippocampal and amygdala volumes of the patients were smaller than those of the healthy controls. OCD severity was not correlated with amygdala volumes but was related to the left hippocampus. Duration of illness was correlated with both hippocampus and left amygdala. Our findings suggest that hippocampus and amygdalar abnormalities can be considered in refractoriness to OCD. (C) 2008 Elsevier Inc. All rights reserved.
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    Neurochemistry of the hippocampus in patients with obsessive-compulsive disorder
    (WILEY-BLACKWELL PUBLISHING, INC, 2009) Atmaca, Murad; Yildirim, Hanefi; Ozdemir, Huseyin; Koc, Mustafa; Ozler, Sinan; Tezcan, Ertan
    Aim: To date, despite possible neuroanatomical importance, no magnetic resonance spectroscopy (MRS) study on hippocampus has been performed in obsessive-compulsive disorder (OCD). The purpose of the present study was therefore to compare hippocampal chemicals in patients with OCD with those in healthy subjects with no psychopathology. Methods: Eighteen patients meeting DSM-IV criteria for OCD and 18 healthy controls were studied. The patients and controls underwent proton magnetic resonance spectroscopy ((1)H-MRS), and measures of N-acetyl-l-aspartate (NAA), choline (CHO), and creatine (CRE) in hippocampal regions were obtained. Results: Both NAA/CRE and NAA/CHO ratios in the hippocampus in patients with OCD were reduced relative to healthy controls. The ANOVA showed a near-significant effect of diagnosis for NAA/CRE and a significant effect for NAA/CHO, but the ANOVA did not show any significant effect even at a trend level for CHO/CRE. No main effect of hemisphere was found for any metabolite ratio. Conclusions: The presence of neuronal degeneration is suggested in OCD. Future longitudinal neuroimaging and neuropsychological studies with larger patient samples are warranted in order to confirm these preliminary findings to better characterize the relevance of neurochemical abnormalities in hippocampus in the pathophysiology of OCD.