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    Can high volume pericapsular nerve group (PENG) block act as a lumbar plexus block?
    (ELSEVIER SCIENCE INC, 2020) Alasehir, Elcin Akduman; Ipek, Belkiz Ongen; Thomas, David Terence; Ercan, Tugba Erener; Sitar, Mustafa Erinc
    Can high volume pericapsular nerve group (PENG) block act as a lumbar plexus block?
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    The Effects of Glutathione on Clinically Essential Fertility Parameters in a Bleomycin Etoposide Cisplatin Chemotherapy Model
    (Mdpi, 2023) Bayram, Hale; Dönmez Çakıl, Yaprak; Sitar, Mustafa Erinc; Demirel, Gamze; Selam, Belgin; Cincik, Mehmet
    Chemotherapeutic agents used in the treatment of testicular cancer cause damage to healthy tissues, including the testis. We investigated the effects of glutathione on sperm DNA integrity and testicular histomorphology in bleomycin etoposide cisplatin (BEP) treated rats. Twelve-week-old male rats of reproductive age (n = 24) were randomly divided into three groups, the (i) control group, (ii) BEP group, and (iii) BEP+ glutathione group. Weight gain increase and testes indices of the control group were found to be higher than that of the BEP group and BEP+ glutathione group. While the BEP treatment increased sperm DNA fragmentation and morphological abnormalities when compared to the control group, GSH treatment resulted in a marked decrease for both parameters. Moreover, BEP treatment significantly decreased serum testosterone levels and sperm counts in comparison to the control group, yet this reduction was recovered in the BEP+ glutathione treated group. Similarly, seminiferous tubule epithelial thicknesses and Johnsen scores in testicles were higher in the control and BEP+ glutathione groups than in the BEP-treated group. In conclusion, exogenous glutathione might prevent the deterioration of male reproductive functions by alleviating the detrimental effects of BEP treatment on sperm quality and testicular histomorphology.
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    The Effects of Initial Procalcitonin Levels on Mortality Rates in Geriatric Patients Undergoing Surgery
    (CUREUS INC, 2020) Ipek, Belkiz Ongen; Karadeniz, Asli; Sitar, Mustafa Erinc
    Introduction The aim of the current study is to investigate the relationship between mortality rate in geriatric patients undergoing surgery with preoperative serum levels of procalcitonin, C-reactive protein, and erythrocyte sedimentation rate. Methods This was a single-center retrospective study, including three groups with 101 patients, who are older than 65 years of age. A retrospective investigation was carried out from the laboratory information system for all groups from January to December 2018. Group 1 included patients who had surgery and then mortality within 30 days after surgery. Group 2 included hospitalized patients who had surgery and no mortality within 30 days after surgery. Group 3 included outpatient patients, who had suspicion for a bacterial infection and then no surgery or no mortality within 30 days. Results When three group comparisons were made for procalcitonin, C-reactive protein, and erythrocyte sedimentation rate values, the p-value of one-way analysis of variance (ANOVA) was higher than 0.05 for procalcitonin and lower than 0.05 for C-reactive protein and erythrocyte sedimentation rate, suggesting that one or more groups were significantly different. When post-hoc multiple comparison methods were applied, there were statistically significant differences between Groups 1 and 3 for C-reactive protein and erythrocyte sedimentation rate. Conclusions Procalcitonin levels do not predict mortality following surgery. C-reactive protein and erythrocyte sedimentation rate are more useful biomarkers predicting mortality in geriatric patients undergoing surgery.
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    Idiopathic chylothorax in geriatrics: the oldest case report so far
    (WALTER DE GRUYTER GMBH, 2018) Ipek, Belkiz Ongen; Alasehir, Elcin Akduman; Sitar, Mustafa Erinc; Levent, Ender; Orki, Alpay
    Chylothorax is a rare condition characterized by accumulation of chylous fluid in the pleural space resulting in impaired ductus thoracic integrity. It can be an outcome of a traumatic process, although there are a few non-traumatic and/or idiopathic cases in current literature. In this article, we present the oldest case report so for, who is an 87-year-old woman complaining of acute respiratory distress symptoms with pleural effusion having no trauma history. The patient was analyzed for the disease etiology strenuously. Thoracentesis was performed together with imaging modalities and detailed systemic laboratory tests. Non-surgical treatment was successful as the outcome.
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    Intercellular Adhesion Molecule-1 Lys469Glu Polymorphism, Systemic Redox Homeostasis and Gestational Diabetes Mellitus in Pregnant Women
    (ELSEVIER SCIENCE BV, 2019) Yanar, Karolin; Aydin, Seval; Simsek, Bahadir; Yaylim, Ilhan; Turan, Saime; Sitar, Mustafa Erinc; Cacina, Canan; Kucukhuseyin, Ozlem; Tuten, Abdullah; Cakatay, Ufuk; Benian, Ali
    Objectives: Intercellular adhesion molecule-1 (ICAM-1) plays an important role in endothelial function. Hyperglycemia-induced impaired redox status is 1 of the well-known pathophysiologic characteristics of gestational diabetes mellitus (GDM), and it plays a crucial role in the causes of disease. Our aim was to clarify any possible relationship between the ICAM-1 Lys469Glu polymorphism and systemic redox status in women with and without GDM. Also, we investigated whether this polymorphism could be associated with a change for better or worse as evidenced by clinical and redox biomarkers. Methods: The ICAM-1 polymorphism statuses of 89 pregnant women without GDM and 53 pregnant women with GDM were found. Stratifying patients based on GDM and polymorphism status, we investigated various redox homeostasis markers. The independent t test was used. Results: Significantly higher systemic oxidative damage and diminished antioxidant defense were found in pregnant women with GDM. Also, results showed that whether pregnant women were carrying the Lys469Glu polymorphism or not did not seem to be associated with significant differences, as evidenced by comparable systemic oxidative damage. Conclusions: Although no significant difference was observed between genotypes, the oxidative damage observed in patients with GDM warrants earlier screening and management in the light of new evidence. (C) 2018 Canadian Diabetes Association.
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    MODULATION OF YAP1 EXPRESSION AND OTHER RELATED SIGNALING PATHWAYS IN HepG2 CELLS BY EXTRACELLULAR MATRIX, CONTACT INHIBITION AND CELL DENSITY
    (Wiley, 2020) Aktaş, Ranan Gülhan; Akbulu, Zeynep; Maras, Hatice, Jr.; Çakıl, Yaprak Dönmez; Kayali, Damia; Karagoz, Ayca; Sitar, Mustafa Erinc
    [Abstract Not Available]
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    Modulation of YAP1 expression and other related signaling pathways in HepG2 cells by extracellular matrix, contact inhibition and cell density
    (American Association for the Study of Liver Diseases, 2022) Aktas, Ranan; Akbulut, Zeynep; Maraş, Hatice; Çakıl Dönmez, Yaprak; Kayalı, Damla; Karagoz Koroglu, Ayca; Sitar, Mustafa Erinc; Kısakol, Batuhan; Baysan, Mehmet
    Background: Hippo-YAP pathway is a key modulator in liver development, regeneration and the metabolism . Cell density, cell contact, the actin cytoskeleton, and extracellular matrix (ECM) composition have been shown to be involved in regulation of this pathway . The intervention of this pathway in hepatocellular carcinoma remains a central focus . The study aimed to examine how YAP1 integrate mechanical cues with the response to signal transduction pathways and to multiple aspects of cell behavior, proliferation, protein/lipid secretion, apoptosis/necrosis, adhesion, and stemness . Methods: HepG2 cells were cultured on uncoated (1), or Type I collagen (2), standard matrigel (3) or high concentration-matrigel coated surfaces (4) for 6 weeks . The cells were examined at 60% or 100%confluency, and at the end of each week by qRT-PCR, confocal microscopy, MTT, ELISA, and flow cytometry. Expression of 84 genes including YAP1, cell adhesion molecules (Inhibin, Cadherin, Na-K ATPase), apoptotic/necrotic changes, viability, protein/ lipid secretion, and existence of 7 different cancer stem cells were compared with Spearmen correlation test . Results: YAP1 gene expression changed significantly in Group1. Contact inhibition with 100% confluency caused deacrease at YAP1 in all groups . It was always low in group4 when compared with the others . Strong correlation between the YAP1, Actin-beta, and most of the genes in TGFB, AKT-P13 and RAS/RAF/MAPK pathways were clear (Graph I) . Positive correlation between cholesterol /LDL/HDL secretion; negative correlation between protein secretion, necrosis and CD133 (+) cells were notable . Conclusion: Herein, we described for the first time how liver cancer cells translate complex and dynamic changes at the external cues into signaling conduits that impact on YAP and other related gene expressions as well as on metabolic and morphological features of the cells . The study demonstrated the striking changes through the receptor of integrin alpha2beta1 that is stimulated by type I collagen . Changes in group 3 and 4 suggest that growth factors in stroma is another important factor at the response related to YAP1 expression. To our knowledge, this is the first study demonstrates Actin and YAP1 interaction at the gene expression level .
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    Morphological and biomechanical effects of vitamin K2 on fracture healing: An animal study on the rat tibia fracture model
    (Turkish Assoc Orthopaedics Traumatology, 2023) Ünal, Ömer Kays; Dağtaş, Mirza Zafer; Ipek, Belkiz Ongen; Sitar, Mustafa Erinc; Ugutmen, Ender
    Objective: The aim of this study was to evaluate the effects of vitamin K2 on fracture healing.Methods: Twenty-four 6-week-old male Wistar albino rats that had open tibia fractures induced were included in this study. They were divided into 2 groups of 12, a group that had vitamin K2 administered over 30 consecutive days and a control group. After 30 days, the rats were sacrificed, and from each group, 6 tibiae were selected for biomechanical testing to examine the mechanical strength of the callus tissue using the Instron 3-point bending test and 6 tibiae were selected for histological analysis to examine the density and organization of callus tissue using Allen's grading system and Huo et al's grading system. Furthermore, weekly x-rays were taken to evaluate bone union described by Lane and Sandhu, and osteocalcin, procollagen I N-terminal propeptide, and procollagen I C-terminal propeptide were examined in blood samples taken by intracardiac puncture during sacrification.Results: Breaking force (P = .047), breaking time (P = .019), stiffness (P = .039), fracture strength (P = .041), and Young's modulus (P = .032) showed a statistically significant increase in the K2 group. Procollagen I C-terminal propeptide (P = .024), procollagen I N-terminal propep -tide (.047), and osteocalcin (.048) levels were significantly higher in the K2 group compared to the control group. Furthermore, 3rd-week x-rays showed higher bone union scores according to the Lane and Sandhu method in the K2 group (P = .014). However, the histological grading systems of Allen and Huo et al did not show statistically significant differences between groups (P = .086, P = .07, respectively).Conclusion: In light of these findings, it could be concluded that vitamin K2 has a significant positive effect on fracture healing.