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Yayın Combined anterior transobturator mesh with four straps and laparoscopic sacrocol-popexy in the treatment of pelvic organ prolapsus: Our early experience in two cases [Pelvik organ prolapsi{dotless} tedavisinde dört kollu transobturator anterior vajinal meş uygulamasi{dotless} ve laparoskopik sakrokolpopeksinin kombinasyonu: Iki olguda erken deneyimlerimiz](2010) Balci M.B.C.; Sinanoglu O.; Taş T.; Ceylan O.; Hazar A.I.; Nuhoglu B.Female pelvic floor instability provokes urinary incontinence, genito-urinary and rectal prolapsus, and sexual dysfunction. Both vaginal and abdominal methods to treat pelvic organ prolapsus (POP) have been developing. Abdominal interventions became less invasive and less morbid with the use of laparoscopy. In this report, two cases of POP treated with a combined application of vaginal mesh by transobturator approach and laparoscopic sacrocolpopexy in the same operational session were presented. Case 1, a 77 year old woman, was diagnosed with stage III cystocele and stage III collum uteri rest prolapsus. The patient had a history of abdominal subtotal hysterectomy and left ooferectomy for a large uterine myoma 30 years ago. Case 2, a 67-year-old woman, was diagnosed with stage III cystocele and vaginal vault prolapse. The patient had a history of total abdominal hysterectomy plus bilateral salpingooophorectomy operation 16 years ago.Yayın Does mild hydronephrosis induced by full-bladder improve outcomes in patients undergoing shock wave lithotripsy for lower calyceal stones?: A prospective randomized study(Urology and Nephrology Research Centre, 2018) Hazar I.A.; Cakiroglu B.; Sinanoglu O.; Akgün F.S.; Arda E.; Yuksel I.; Akdere H.Purpose: To compare the outcomes, sessions and shock wave numbers in patients undergoing standard procedure shock wave lithotripsy (SWL) and patients undergoing SWL with mild hydronephrosis induced by full-bladder following oral hydration before SWL procedure for lower calyceal stones. Materials and Methods: Between January 2014- January 2016 a total of 371 patients who underwent SWL, for lower pole calyceal stones ? 2 cm, were included into the study. 127 patients were treated in the supine position (Group A), 123 in the prone position (Group B) and 121 in the prone position with full bladder and mild hydronephrosis checked by ultrasound before procedure (Group C). There were 286 men and 85 women with a mean ± SD age of 36 ± 11 years Results: The mean (SD) stone sizes within the group A, group B and group C were 11 mm (±3 mm), 12 mm (±4.1 mm) and 11 mm (± 3.8 mm) respectively. No significant difference was found in age (P = .18) and stone size between 3 groups (P = .07). The median interquartile range (IQR) number of shocks within the group A, group B and group C were 7600 (3855), 6500 (4300) and 6700 (4915) respectively. Significant difference was found in number of shock waves among 3 groups (P < .01). The difference between groups according to stone expulsion rate was found significant in all sessions (P = .01). Conclusion: The present study suggests that mild hydronephrotic status induced by full-bladder before SWL can lower cost and patient discomfort by decrease in number of sessions and increase in stone clearance. © 2018 Urology and Nephrology Research Centre.Yayın The Effect of Tamsulosin on Pain and Clearance According to Ureteral Stone Location After Shock Wave Lithotripsy(2013) Basri Cakiroglu; Sinanoglu O.; Mahmure UrazBackground: Medical expulsion therapy has shown encouraging results in facilitating spontaneous clearance of ureteral stones after extracorporeal shock wave lithotripsy. However, no other study has yet determined the benefit of medical expulsion therapy for stones in different ureteral locations. Objective: The aim of the study was to evaluate tamsulosin as adjunctive therapy to extracorporeal shock wave lithotripsy (SWL) in terms of pain clearance of stones in the upper, middle, and lower ureter. Methods: Between June 2008 and July 2011, patients with a solitary ureteral stone that was ?6 mm up to 15 mm and located in the upper, middle, or lower ureter undergoing SWL were evaluated. The patients were randomly allocated to a conservative treatment (group 1) and a tamsulosin treatment group (group 2). Administration of the drug was started immediately after SWL and was continued for a maximum of 28 days. Patients were evaluated for stone clearance, time to stone clearance, and number of SWL sessions. The pain intensity was evaluated by visual analog scale. Results: There were 64 patients in the control group and 59 in the tamsulosin group. The average stone sizes were 10.70 (3.20) mm and 11.40 (3.01) mm ( P = 0.24). Group 1 and group 2 received 2507 (984) and 2759 (775) shock waves ( P = 0.86), 1.53 (0.8) and 1.49 (0.75) sessions ( P = 0.85), respectively. Mean visual analog scale scores and times to clearance were 3.81 (2.74) and 2.73 (2.28) ( P = 0.00) and 12.59 (8.63) days and 8.34 (7.60) days ( P = 0.00), respectively, for all stones in groups 1 and 2. Only the clearance time of upper ureteral stones between groups showed statistical significance (13.54 [8.32] days vs 7.10 [6.40] days; P = 0.00). Conclusions: Tamsulosin may help in the treatment of all ureteral stones after SWL, particularly stones in the upper ureter, with a shorter time to clearance and less need for analgesic drugs. © 2013 The Authors.Yayın Effects of spirulina on cyclophosphamide-induced ovarian toxicity in rats: Biochemical and histomorphometric evaluation of the ovary(2013) Yener N.A.; Sinanoglu O.; Ilter E.; Celik A.; Sezgin G.; Midi A.; Deveci, Uğur; Aksungar F.; Deveci, UğurCyclophosphamide (Cyc) is known to cause ovotoxicity and infertility in women. Our aim is to investigate the possible ovotoxic effects of Cyc and possible antioxidant and protective effects of blue-green algae, Spirulina (Sp), in rat ovaries. Eighteen rats were given: group I (n = 6, control); group II (n = 6, CP), a single dose Cyc; group III (n = 6, Sp+Cyc), 7 days Sp+single dose Cyc. Tissue malondialdehyde (MDA) levels, superoxide dismutase (SOD), and catalase (CAT) activities are assessed biochemically. Normal and atretic primordial and primary follicle counts for all sections obtained for each ovary are calculated. Mean number of follicle counts for each group are compared. In Sp+Cyc group, tissue MDA levels were significantly lower than those in the CP and higher than those in the C group (CP > Sp + Cyc > C). Tissue SOD activity was significantly higher in Sp+Cyc group than that in the CP group and lower than that in the C group (C > Sp + Cyc > C). No statistically significant difference was found between the ovarian CAT activities in any group. Histomorphometrically, there was also no significant difference between the mean numbers of normal and atretic small follicle counts. Our results suggest that single dose Cyc has adverse effects on oxidant status of the ovaries and Sp has protective effects in Cyc-induced ovotoxicity. © 2013 Nese Arzu Yener et al.Yayın Efficacy and safety of 120w greenlight photoselective vaporisation of prostate in patients receiving anticoagulant drugs(2013) Çakiroglu B.; Gözüküçük R.; Sinanoglu O.Objective: To evaluate the efficacy and safety of photoselective prostate vapourisation with 120w potassium titanyl phosphate laser in benign prostate hyperplasia patients receiving oral anti-coagulant therapy. Methods: The retrospective study was conducted at Istanbul Hisar International Hosptial and comprised 63 male patients who were on anti-coagulant therapy for comorbidities and who underwent prostate vapourisation for benign prostate hyperplasia with 120 Watts potassium titanyl phosphate from November 2007 to December 2010. International Prostate Symptoms Score, Quality of Life scores, uroflowmetry pre-operatively and 3 months postoperatively were obtained. Ultrasound examination was performed for each patient to evaluate prostate and residual urine in the bladder. Plasma haemoglobin, haematocrit and International Normalised Ratio levels were also checked for patients in the pre-and post-operative period. Results: The age range of the patients was from 65-89 years with a mean of 72.3±8 years. The mean prostate weight was 45±17ml (range: 40-120). Mean operation time was 54±16 minutes (25-90). The removal of urinary catheter took place 1-3 days post-operatively. None of the patients required transfusion. The International Prostate Symptoms Score was reduced (23±6 vs 14±3) at third month after the operation. Quality of Life scores were improved from 2.2±1.1 to 4.7±1.2, and maximal urine flow rate increased from 7.8±2.3 to 16±1 in the same period. Urinary obstruction due to clot retention was observed in 1 (1.58%) patient in post-operative 3 days. Urinary retention occurred in 5 (7.98%) patients after the removal of the urinary catheter. Permanent urinary retention, peroperative bleeding and post-operative incontinence were not observed. Conclusion: Treatment of benign prostate hyperplasia with photoselective prostate vapourisation is effective and safe in patients receiving anti-coaguant therapy. However, patients should be monitored in early post-operative period for macroscopic haematuria and transient urinary retention.Yayın Long-term effect of colchicine treatment in preventing urethral stricture recurrence after internal urethrotomy(Urology and Nephrology Research Centre, 2018) Sinanoglu O.; Kurtulus F.O.; Akgun F.S.Purpose: Urethral stricture, known as a scar formation leading to urethral lumen stricture in sub-epithelial tissue, is the most common late complication of transurethral prostate resection (TURP). The aim of study is to evaluate efficacy of colchicine treatment in preventing urethral stricture recurrence in patients after internal urethrotomy, and to determine whether colchicine treatment had a sustained effect in decreasing stricture recurrences in patients with concomitant diseases. Methods: Patient data with weak urine stream and/or voiding difficulty, and who had internal urethrotomy in Urology Department of Maltepe University Hospital between dates 01 January 2011 and December 2016 were collected. They were randomized to colchicine receiving, and non-receiving arms. Colchicine was given 1 g/day orally for two months, and primary efficacy point was defined as urethral stricture development in 3, 6, and 12 months after internal urethrotomy. Results: The study was conducted on 84 males with the mean age of 67.7 ± 7.5 years. The mean ages of colchicine receivers and non-receivers were 68.2 ± 7.6 and 67.1 ± 7.6 years, respectively. Recurrence rate of urethral stricture was significantly lower in colchicine receivers (P = .044) than non-receivers. In overall evaluation, recurrence rate of urethral stricture was significantly low, if there was only one comorbidity (P = .006), but rates were significantly higher in presence of three (P = .010) and four (P = .040) comorbidities. No significant difference in recurrence rates was determined in patients without comorbidities or with two comorbidities (P > .05). Conclusion: Combination of oral colchicine with internal urethrotomy reduces recurrence rates of urethral stricture significantly. © 2017, Urology and Nephrology Research Centre.Yayın MRI in stress urinary incontinence: Endovaginal MRI with an intracavitary coil and dynamic pelvic MRI(2012) Tasali N.; Cubuk R.; Sinanoglu O.; Sahin K.; Saydam B.Purpose: To evaluate both morphology of the urethra and its supporting structures using endovaginal magnetic resonance imaging (EV-MRI) and the grade of the bladder neck prolapsus using dynamic pelvic MRI (DP-MRI) in women with stress urinary incontinence (SUI). Materials and Methods: We compared 25 women with SUI and 8 controls according to the different layers of the urethra, the degree of distortion in the pe-riurethral, paraurethral, and pubourethral ligaments, the vesicourethral angle, the retropubic space, and the thickness of the puborectal muscle. The SUI group was also evaluated according to the number of deliveries and degree of the bladder neck prolapsus. Results: Significant differences were found in the thickness of each three layers of the urethra between the two groups (P < .05). There was a significantly higher pubourethral ligament distortion (P = .024) and larger vesicourethral angle (P = .000) in women with SUI. In women with SUI, there was no significant relationship between the number of deliveries and the degree of the bladder neck prolapsus (P > .05). Conclusion: The combined usage of the EV-MRI and DP-MRI can provide complementary information concerning certain structural abnormalities with specific dysfunction, such as vesicourethral angle increase and pubourethral ligament distortion in patients with SUI.Yayın An unusual cause of hematuria; Primary epiploic appendagitis(Elsevier Ltd, 2014) Cakiroglu B.; Sinanoglu O.; Abci I.; Tas T.; Dogan A.N.; Aksoy S.H.; Bilsel Y.PRESENTATION OF CASE Herein, a 40 years old patient describing abdomino-inguinal pain with clotty hematuria having PEA was presented. At first, the patient was thought to have a primary bladder pathology, but after a meticioulus examination, he found to have PEA and managed by conservative measures.DISCUSSION Although PEA does not require surgical intervention, it may mimic other acute abdominal disorders which can be difficult to differentiate. Appendices overlying the sigmoid colon and cecum are more prone to be affected as they are more elongated and wider in size. The patient is usually admitted due to sudden onset of abdominal pain accompanied with fever, abdominal tenderness and leucocytosis.CONCLUSION The present case demonstrated that PEA located close to the lower urinary tract especially urinary bladder might present with urinary symptoms such as hematuria. dysuria, pollakuria and inguinal pain.INTRODUCTION Primary epiploic appendagitis (PEA) is self limiting inflammatory disease of colonic epiploic appendices. © 2014 The Authors. Published by Elsevier Ltd.