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    The Effect of Vitamin C on Ischemia Reperfusion Injury Because of Prolonged Tourniquet Application With Reperfusion Intervals
    (LIPPINCOTT WILLIAMS & WILKINS, 2009) Ulug, Burcak Tumerdem; Aksungar, Fehime Benli; Mete, Ozgur; Tekeli, Fatma; Mutlu, Nilgun; Calik, Burcu
    We examined the effect of vitamin Con muscle injury distal to the tourniquet which was applied for 4 hours with 10- and 20-minute reperfusion intervals after 2 hours of tourniquet. Sixty-four Sprague-Dawley rats were allocated to 4 randomized groups. After 2 hours tourniquet, 10- and 20-minutes of reperfusion were allowed to half of each group respectively. Afterward an additional 2 hours compression was applied. Except the control group the animals received vitamin C intravenously, before the first tourniquet in Group 1, at the reperfusion interval in Group 11, and at both times in Group III. Malondialdehyde levels were measured in blood and the tibialis anterior muscle. The muscle was histopathologically examined. The data was evaluated statistically. The effects of timing and the dose of vitamin C on ischemia reperfusion injury remain controversial and there was no statistical difference between 10- and 20-minute reperfusion intervals. But the blood malondialdehyde levels showed that vitamin C has a positive effect on the muscle injury caused by ischemia-reperfusion.
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    Serotonin dilemma in postmenopausal women: Is it low or high?
    (ELSEVIER IRELAND LTD, 2008) Haliloglu, Berna; Aksungar, Fehime Berth; Ilter, Erdin; Akin, Figen Temelli; Mutlu, Nilgun; Peker, Hakan; Ozden, Selcuk
    Objective: In this study, we have studied with premenopausal (PM), naturally menopausal (NM) and surgically induced menopausal (SM) women in order to investigate the differences in serum cortisol, dehydroepiandrosterone sulfate (DHEA-S), follicle stimulating hormone (FSH) and estradiol (E2) levels on serum serotonin levels. Methods: Forty premenopausal (36.7 +/- 3.5 years), 40 naturally menopausal (54.2 +/- 8.4 years) and 38 surgically induced menopausal (55.4 +/- 11.2 years) women were included in the study. None of the subjects were using antidepressants or hormone replacement therapy. In NM and SM, years since menopause (YSM) were 3.16 +/- 1.58 and 3.36 +/- 1.89, respectively. Cortisol, DHEA-S, FSH and E2 levels were determined by immunochemiluminisence while serotonin levels were determined by HPLC. Results: Serum serotonin levels in NM women were higher than the other two groups [144.23 +/- 45.29 mu g/L vs 61.35 +/- 37.72 mu g/L in SM women and 98.74 +/- 50.29 mu g/L in PM women]. E2 and DHEA-S were positively correlated, while FSH and cortisol were negatively correlated with serotonin in NM and SM. There was no significant correlation between serotonin and age or YSM. In the PM group, there was no significant correlation between serotonin and the hormones. Conclusion: In conclusion, increased serotonin levels in naturally menopausal women may be a compensatory mechanism to decreased E2 levels as it is postulated that there is strong interaction between E2 and the serotoninergic system. (C) 2008 Elsevier Ireland Ltd. All rights reserved.