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Yayın Antioxidant effect of pomegranate extract in reducing acute inflammation due to myringotomy(CAMBRIDGE UNIV PRESS, 2011) Kahya, V.; Meric, A.; Yazici, M.; Yuksel, M.; Midi, A.; Gedikli, O.Objective: To assess the effect of pomegranate extract on acute inflammation due to myringotomy. Design: Prospective, randomised study. Subjects: Thirty Sprague-Dawley rats were divided into three groups. Group one constituted controls. Group two underwent myringotomy. Group three underwent myringotomy and also received 100 mu l/day pomegranate extract, via gavage, one day before and two days after surgery. Following sacrifice 48 hours after myringotomy, the animals' right ears were used to determine the concentration of reactive oxygen species, using the chemiluminescence method; left ears were used for histological study. Results: Reactive oxygen species levels were significantly decreased in group three compared with group two (p < 0.01). The density of inflammatory cells in group three was significantly less than that in group two (p < 0.01). Lamina propria thickness and vessel density were also significantly decreased in group three compared with group two (p < 0.01). Conclusion: Our results indicate that oral pomegranate extract decreases reactive oxygen species concentration and acute inflammation in the tympanic membrane after myringotomy.Yayın Cauda equina paraganglioma with ependymal morphology: A rare case report(I HOLZAPFEL VERLAG GMBH, 2010) Erban, T.; Erban, N.; Midi, A.; Yener, N.; Cubuk, R.; Sav, A.…Yayın Comparison of the histopathological results of the endometrial thickness detected by transvaginal ultrasound of symptomatic and asymptomatic postmenopausal women(I R O G CANADA, INC, 2016) Ulu, I.; Celik, A.; Haliloglu, B.; Ilter, E.; Midi, A.Objective: The purpose of the study was to assess the reliability of transvaginal ultrasound (TVUSG) in endometrial pathologies by comparing the ultrasonographic and histopathologic findings in symptomatic and asymptomatic postmenopausal women.,Materials and Methods: In this retrospective study the data of 129 postmenopausal women that underwent dilatation and curettage was reviewed by dividing them two groups as symptomatic and asymptomatic. Symptomatic group was divided into subgroups according to the value of endometrial thickness obtained by TVUSG. Results: Among all subjects the cancer rate was found statistically 3.043 times higher in patients with the endometrial thickness of 15 mm and greater and atrophic endometrium rate was 75% in patients with the endometrial thickness of less than five mm. Endometrial thickness was found significantly higher in cancer patients than the others (p < 0.05). Among the patients with endometrial thickness of 15 mm and greater, the cancer rate was found higher in symptomatic group than in the asymptomatic group. The cancer rate was found statistically higher in patients with bleeding compared to asymptomatic ones with the endometrial thickness between 5-14.99 mm (p < 0.05). Cancer was not detected in any of the symptomatic patients with the endometrial thickness of less than five min. Conclusion: Postmenopausal patients with the symptom of bleeding should undergo detailed gynecological and ultrasonographic examination. The authors believe that this study may be a strong support to the success of TVUSG as a screening method in both symptomatic and asymptomatic postmenopausal women. Furthermore if the patient is symptomatic with a thick endometrium, to exclude the malignancy, endometrial biopsy must he performed.Yayın A giant villous adenoma: case mimicking rectosigmoid malignancy; radiological survey to diagnosis.(2010) Çubuk, R.; Tasali, N.; Arslan, G.; Midi, A.; Manukyan, Manuk Norayık; Guney, S.Villous adenomas are benign lesions, which are difficult to interpret because of their malignancy potential. They have similar radiological findings to malignant lesions. Usually, villous adenomas are asymptomatic although they may cause rectal bleeding like malignant tumours. We present a case of giant villous adenoma to evaluate the contribution of its radiological features including double contrast barium enema, computed tomography and magnetic resonance imaging examinations for the differential diagnosis.Yayın Investigation of the effect of radiotherapy on the proliferative index (Ki-67) in recurring diffuse glial tumors(Ege University Press, 2011) Midi, A.; Belirgen, M.; Çag?lar, H.; Sav, A.Introduction: Radiotherapy (RT) has various effects such as apoptosis stimulation, mitosis inhibition, mutagenic effect, chromosomal aberration and neoplastic transformation. Aim: The aim of this study was to investigate the effect of RT administered to diffuse glial tumors on the proliferation activity and mitotic activity of the tumor. Material-Method: An overall of 49 re-operated recurrent cases (16 cases had received postoperative RT while 33 cases did not receive RT) diagnosed as glial tumor were included in this study. The tumor cohort consisted of diffuse astrocytoma, oligodendroglioma and oligoastrocytomas. Ki-67 proliferating index, mitoses and grades of the primary and recurrent tumors were compared. Result: We found that the grades of recurrent tumors were lower than the grade during the first surgery in cases that had RT compared to those that had not. Similarly, Ki-67 was lower in cases that had received RT. We also noted suppressed mitotic activity in cases that had received RT.Yayın Xanthogranulomatous cystitis: a challenging imitator of bladder cancer(SPRINGER, 2009) Ekici, S.; Ekici, Dogan A., I; Midi, A.; Eroglu, A.; Ruacan, S.…
