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    Immunohistochemical demonstration of cytochrome oxidase in different parts of the central nervous system: a comparative experimental study
    (Wiley, 2008) Taşkınalp, Oğuz; Cığalı, Bülent Sabri; Kutlu, A. K.
    Cytochrome oxidase, the terminal enzyme of the electron transport chain, is a marker of the functional activity of the cell. In this study; localization of cytochrome oxidase in cerebrum, cerebellum, hippocampus, substantia nigra and choroid plexus of adult rats was investigated using immunohistochemical methods. Neural bodies were immunoreactive while neuroglial cells and axonal areas did not show significant immunostaining. The cerebral cortical substantia grisea region was stained almost homogeneously with cytochrome oxidase. In the cerebellar cortex, immunolabelling was more intense in the granular layer than the molecular layer. There was significant immunostaining in Purkinje cells. White matter, both in cerebrum and cerebellum, did not show immunoreactivity for cytochrome oxidase. Neurones in the hippocampus showed variable immunostaining; some of them were negative while others revealed high immunoreactivity. The neurones in substantia nigra were heavily labelled. Immunostaining for cytochrome oxidase in plexus choroideus epithelial cells was also remarkable. The morphological findings demonstrate the regions which most require and produce energy and reflect the differences in cellular activity in these parts of the central nervous system.
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    Ultrastructural and histochemical characterization of secretory granules in human lung adenocarcinoma cells
    (Cambridge University Press, 2000) Demiralay, E.; Altaner, S.; Candan, L.; Kutlu, A. K.
    Histochemical methods offer an excellent research tool for the characterization of glycoproteins in the secretory cells, thus contributing to the elucidation of the pathophysiology of different diseases. The different staining characteristics of mucins can be useful in diagnostic histopathology. It has been proposed that the reduction in sulphated glycoproteins and an increase in sialomucins in intestinal mucosa was an indicator of premalignant changes in carcinoma of the bowel. It has subsequently argued that this change may be consequence rather than a precursor of neoplasia. It may still be of some value as a marker of a premalignant change although it is somewhat variable. Previous studies have demonstrated the characterization of glycoproteins in different type of epitheloid cells in normal and pathologic conditions by using histochemical and electron microscopic techniques. However; little information has been available concerning the exact features of secretory granules in both normal and tumoral cells in lung.