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Yayın Associations of Attachment and Coping Styles With Social Functioning in Patients With Bipolar Disorder I(Lippincott Williams & Wilkins, 2021) Karas, Hakan; Carpar, Elif; Kucukgoncu, Suat; Kaser, MuzafferThe aim of this study was to investigate the relationship of attachment and coping mechanisms with social functioning in patients with bipolar disorder (BD). Sixty-three patients with BD type I and 63 healthy controls were evaluated. Structured Clinical Interview for DSM-IV Axis I Disorders, Hamilton Depression Rating Scale, Young Mania Rating Scale, Experiences in Close Relationships Questionnaire II, Coping Orientation to Problems Experienced (COPE) inventory, and Social Functioning Scale were used. In the BD group, adaptive coping style scores and attachment avoidance scores were significantly lower than the control group, but mean scores of maladaptive coping styles were higher than the control group. Regression analysis showed that positive reinterpretation and growth, active coping, use of emotional social support, planning, religious activities, and mental disengagement subscales of COPE were significantly associated with social functioning. Psychosocial interventions to strengthen adaptive coping mechanisms may help improve the social functioning in patients with BD.Yayın Can complete blood count parameters be a good marker for substance use disorder?(Taylor & Francis Inc, 2023) Arat Çelik, Hidayet Ece; Kendirlioğlu, Burcu Kok; Tunç, Ayşe Ece Büyüksandalyacı; Çörekli, Esma; Demir, Sevin; Kucukgoncu, SuatObjectiveInflamatory processes play an important role in the etiology of psychiatric disorders. The aim of this study was to evaluate inflammatory complete blood count (CBC) parameters in substance use disorder (SUD).MethodsThe study included 90 patients with SUD and 90 healthy controls (HC). The Student t-test was used to compare CBC parameters between the groups. The Kruskal - Wallis test was used to compare the data on the basis of substance types.ResultsLeukocyte, lymphocyte, and monocyte levels were higher in SUD group than HC. Leukocyte and neutrophil levels of patients with opioid use disorder (OUD) were higher than HC. Platelet levels and neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and systemic immune inflammation index values were higher in patients with OUD than in patients with non-opioid substance use disorder (nOUD). Moreover, lymphocyte and monocyte levels were higher in patients with nOUD than in HC. Monocyte levels were increased in patients with cannabinoid use disorder compared to HC.ConclusionThe results suggested that inflammatory CBC parameters play an important role in the etiology of SUD according to type of substance. However, there is not enough data for supporting the clinical use of these parameters..Yayın A comparative meta-analysis of peripheral 8-hydroxy-2?-deoxyguanosine (8-OHdG) or 8-oxo-7,8-dihydro-2?-deoxyguanosine (8-Oxo-DG) levels across mood episodes in bipolar disorder(Wiley, 2023) Arat Çelik, H. E.; Tuna, Gamze; Ceylan, Deniz; Kucukgoncu, Suat[Abstract Not Available]Yayın A comparative meta-analysis of peripheral 8-hydroxy-2?-deoxyguanosine mood episodes in bipolar disorder(Pergamon-Elsevier Science Ltd, 2023) Arat Çelik, Hidayet Ece; Tuna, Gamze; Ceylan, Deniz; Kucukgoncu, SuatObjective: Oxidative DNA damage has been associated with the pathophysiology of bipolar disorder (BD) as one of the common pathways between increased medical comorbidity and premature aging in BD. Previous evidence shows increased levels of oxidatively induced DNA damage markers, 8-hydroxy-2 '-deoxyguanosine (8-OHdG) or its tautomer 8-oxo-7,8-dihydro-2 '-deoxyguanosine (8-oxo-dG), in patients with BD in comparison to healthy individuals. With the current research, we aim to analyze data on peripheral (blood or urine) 8-OHdG/8-oxo-dG levels across mood states of BD using a meta-analytical approach.Method: A literature search was conducted using the databases PubMed, Scopus, and Web of Science to identify eligible studies (January 1989 to July 2022). Relevant studies were systematically reviewed; a random-effects meta-analysis and a meta-regression analysis were conducted.Results: The current meta-analysis included 12 studies consisting of 808 BD patients (390 in euthymia, 156 in mania, 137 in depression, 16 in mixed episode, 109 not specified) and 563 healthy controls. BD patients that were currently depressed had significantly higher levels of 8-OHdG/8-oxo-dG than healthy controls, while euthymic or manic patients did not differ from healthy controls. A meta-regression analysis showed sex distri-bution (being female) and older age to be significantly related to increased 8-OHdG/8-oxo-dG levels.Conclusion: Our findings suggest that 8-OHdG/8-oxo-dG may be a state-related marker of depression in BD and may be affected by older age and female gender.Yayın Double-Edged Sword: A Case with Withdrawal-Emergent Dyskinesia(Turkiye Sinir Ve Ruh Sagligi Dernegi, 2021) Arat Çelik, Hidayet Ece; Kok-Kendirlioğlu, Burcu; Çetin, Busra; Kucukgoncu, SuatTardive dyskinesia is defined as involuntary athetoid or choreiform movements that develop due to the use of neuroleptic drugs for at least a few months. Tongue, lower face, jaw, upper and lower extremities are the most affected parts of the body in tardive dyskinesia. Quality of life is negatively affected because of the low remission rates. Besides tardive dyskinesia, involuntary movements may appear after discontinuation, change or a reduction in the dose of antipsychotic medications, which is called withdrawal-emergent dyskinesia (WED). Unlike tardive dyskinesia, the involuntary movements involve mainly the neck, trunk, and limbs and regress in shorter period of time in WED. A consensus has not yet been reached for the treatment of WED. Restarting the previous antipsychotic agent with slow titration or switching to an atypical antipsychotic with low affinity for dopamine D2 receptors are among the primary options for treatment. As WED is one of the predictors of tardive dyskinesia development, early detection and treatment is believed to have positive effect on the quality of life. In this report, the case of a patient followed up for bipolar disorder type I (BD-I) and started on clozapine for WED after discontinuation of haloperidol on account of adverse effects is discussed. It is necessary for clinicians to consider these types of complications when discontinuing or changing treatment. Further research is needed in order to reach a common approach for the treatment of WED.Yayın Effects of Sexual Myths and Intimate Partner Violence on Women's Sexual Self-Schemas(Springer/Plenum Publishers, 2024) Kendirlioglu, Burcu Kok; Kucukgoncu, SuatSexual self-schemas (SSSs) are cognitive generalizations about one's sexual aspects. The aim of this study was to explore the possible effects of intimate partner violence (IPV) and the sexual myths about sexual behavior or roles on women's sexual self-schemas. The research had a cross-sectional and observational design. Fifty women from a psychiatry outpatient clinic between the ages of 18-50 were given the Sexual Self-Schema Scale, sexual myths questionnaire, Beck Depression Inventory, Beck Anxiety Inventory, Golombok-Rust Inventory of Sexual Satisfaction, and Domestic Violence Against Women Scale. A significant relationship was found between the duration of marriage (years) and Direct/Outspoken schema (p = .020, r = 0.29). This schema was also correlated with emotional (p = .037, r = - 0.29), total violence score (p = .028, r = - 0.27), and sexual myth score (p = .033, r = 0.26). After the regression analysis, it was observed that the effect of emotional violence and sexual myth score on the Direct/Outspoken schema remained significant. Correcting sexual myths through sexual education can make women's SSSs into positive way. In addition, interventions can be made to increase SSSs positively in women exposed to IPV. It is recommended that clinicians take a holistic approach by questioning the sexual functions and schemas of women in addition to IPV in women who experience it and have depression or anxiety disorders. As a policy implication, education about women's rights and sexuality should also be given. Adequate psychological support should be provided to reduce the impact of IPV on SSS.Yayın Parkinsonism Symptoms After Exposure to Low-Dose Aripiprazole(Lippincott Williams & Wilkins, 2023) Çörekli Kaymakci, Esma; Kök Kendirlioğlu, Burcu; Kucukgoncu, Suat[Abstract Not Available]Yayın Treatment Adherence in Patients with Bipolar Disorder and Beliefs Related to Non-Adherence(Yerkure Tanitim & Yayincilik Hizmetleri A S, 2020) Uygun, Ersin; Kucukgoncu, SuatObjective: Our aim in this study was to identify treatment adherence in bipolar disorder patients who regularly use medications and to examine the factors and beliefs associated with treatment compliance. Methods: Our sample consisted of 92 patients who were followed up by bipolar disorder. Participants assessed for diagnosis and remission by criteria of affective disorders part of SCID I then Sociodemographic data form, Morisky Medication Adherence Scale (MMAS) and The Beliefs about Medication Compliance Scale (BMCS) was given. Results: Treatment non-adherence rate were %29,3. Variables that differ significantly in non-adherent group then adherent as follows: low education (p=0.03), medications that causes sedation (p=0,001), not educated about treatment (p=0,05), young age (p=0,04), difficulty in obtaining medicine (p=0,003) and treatment complexity (p=0,01). Particularly training the patient with written/visualized materials were higher in adherent group (p=0,02). While there was no significant difference in terms of BMCS benefit subscale (p=0,47), patients with poor treatment compliance reported significantly higher scores on the BMCS barrier subscale (p=0,01). In the logistic regression analysis, sedative medications, difficulty in obtaining medication and treatment complexity were found to be significant predictors of treatment non-adherence. Conclusion: providing access to medication, informing the prescribing medicines with using visual material and patient-centered approaches would increase the compliance of the medication, especially with minimal use of sedative drugs.
