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Yayın Amniotic membrane in the management of strabismus reoperations(SPRINGER JAPAN KK, 2013) Tugcu, Betul; Helvacioglu, Firat; Yuzbasioglu, Erdal; Gurez, Ceren; Yigit, UlviyeTo reduce postoperative scar formation and to improve duction using amniotic membrane (AM) in strabismus reoperations. A prospective study of interventional case series comprised of 14 patients with restrictive strabismus. Objective clinical findings (visual acuity, angle of deviations and degree of duction deficits) were recorded in both the pre- and post-operative periods. Strabismus surgery included the excision of adhesions and scar tissue, repositioning of extraocular muscles (according to the degree of deviations) and placement of two sheets, one between muscle and tenon and the other between muscle and sclera. Conjunctival recession with covering of the bare sclera using AM was also performed. The mean preoperative deviation of the patients was 34.3 prism diopters (PD) and mean post-operative deviation was 4.6 PD. The mean pre-operative duction deficit of the patients was 1.7; mean post-operative duction deficit was 0.2. Postoperatively all patients improved in relation to deviation and duction. Less than 8 PD deviations with no duction deficits were achieved in 12 (86 %) of the patients. Amniotic membrane placement around the extraocular muscle improves the duction and decreases the residual angle of deviations by inhibiting postoperative scar formation.Yayın THE ANALYSIS OF CULTURE RESULTS OF THE RIMS THAT BELONG TO THE DONOR CORNEAS WITH OR WITHOUT VANCOMYCINE APPLICATION IN PENETRATING KERATOPLASTY OPERATIONS(NOBEL ILAC, 2009) Yigit, Ulviye; Bilen, Harun; Agachan, Ahmet; Ozdemir, Secil; Helvacioglu, Firat; Sencan, SadikObjective: The purpose of this paper is to compare the culture results of donor corneas in penetrating keratoplasty operations with or without vancomycine application and to evaluate the efficacy of vancomycine. Material and Method: The study was performed on Haseki Eye Bank corneas from as a prospective, randomised, double blind and multicentered study. 94 donor corneas of 47 bodies were included. The corneal tissues taken from the corpses were carried to the tissue supply center in Optisol-GS solution (gentamycine, strepto-mycine). In tissue supply center the corneas taken from the same body were divided into two groups and sent to two different surgeons. Mile 1 mg/ml vancomycine was applied to the corneas in the first group for 5 minutes, nothing was clone to the corneas in the second group. All corneal rims were carried to the microbiology lab in sterile tubes. Results: Postoperative endophthalmitis was observed in none of the 94 eyes which the corneas were transplanted with or with-out vancomycine application. Mile the culture results in 2 (4.3%) of the 47 donor rim tissues which vancomycine was applied were positive, 6 (12.7%) of the 47 donor rim tissues without vancomycine application were positive. No statistically significance was observed between the two groups. On the side in two donor corneas taken from the same body the same bactery type was positive. Conclusion: Althought no significant difference was observed in this study, we believe that, as the literature supports, with the increase in the number of the cultured corneas statistically significant results will be reached.Yayın Comparison of Two Different Ultrasound Methods of Phacoemulsification(ELSEVIER SCIENCE INC, 2014) Helvacioglu, Firat; Yeter, Celal; Sencan, Sadik; Tunc, Zeki; Uyar, O. MuratPURPOSE: To compare the safety and efficacy of micro-coaxial phacoemulsification surgeries performed with the OZil Intelligent Phaco torsional mode (Alcon Laboratories, Inc., Fort Worth, USA) and combined torsional/longitudinal ultrasound mode using 45 degree aperture angled tips. DESIGN: Prospective randomized clinical trial. METHODS: SETTING: Maltepe University, Istanbul. PATIENT POPULATION: Eighty eyes of 80 cataract patients were randomly assigned to 2.2 mm microcowdal phacoemulsification using the OZil Intelligent Phaco torsional mode (Group 1) or combined torsional/longitudinal ultrasound mode (Group 2). OBSERVATION PROCEDURE: Intraoperative fluid and energy usage and postoperative examinations were evaluated. MAIN OUTCOME MEASURES: Ultrasound time, cumulative dissipated energy, longitudinal and torsional ultrasound amplitudes, mean operation time, mean volume of fluid used, and surgical complications. RESULTS: Both groups included 40 eyes. Mean ultrasound time, cumulative dissipated energy, and longitudinal and torsional ultrasound amplitudes in Group 1 were 58.21 +/- 33.81 seconds, 7.74 +/- 6.23, 0.45 +/- 0.30, and 26.30 +/- 12.60%, respectively, and these parameters in Group 2 were 64.75 +/- 30.23 seconds, 12.61 +/- 6.21, 26.32 +/- 5.85, and 40.98 +/- 8.33%, respectively. Cumulative dissipated energy and longitudinal and torsional amplitudes were found to be significantly lower in Group 1 (P = .001, P < .001, P < .001). Mean volumes of fluid used in Groups 1 and 2 were 73.30 +/- 19.87 cc and 107.07 +/- 21.82 cc, respectively (P < .001). CONCLUSION: With the aid of a 45 degree aperture angled tip, the OZil Intelligent Phaco torsional mode provided more effective lens removal than the combined torsional/longitudinal ultrasound mode, with a lower cumulative dissipated energy and volume of fluid used. (C) 2014 by Elsevier Inc. All rights reserved.Yayın Effect of Corneal Incision Enlargement on Surgically Induced Astigmatism in Biaxial Microincision Cataract Surgery(TURKISH OPHTHALMOLOGICAL SOC, 2016) Tetikoglu, Mehmet; Yeter, Celal; Helvacioglu, Firat; Aktas, Serdar; Sagdik, Haci Murat; Ozcura, FatihObjectives: To evaluate surgically induced astigmatism (SIA) in biaxial microincision cataract surgery with enlargement of one corneal incision during intraocular lens implantation (IOL). Materials and Methods: Data from 683 eyes with cataract that underwent biaxial microincision cataract surgery and IOL were retrospectively analyzed. The operated eyes were divided into 4 groups defined by final corneal incision length after IOL implantation. There were 83 eyes with 1.6 mm corneal incisions (group 1) and 200 eyes in each of the 2, 2.4, and 2.8 mm corneal incision groups (groups 2, 3 and 4, respectively). SIA was assessed using preoperative and postoperative keratometric values at one month. Results: The mean magnitude of SIA was 0.83+/-0.4 D in group 1, 0.93+/-0.5 D in group 2, 1.03+/-0.6 D in group 3 and 1.04+/-0.7 D in group 4. The SIA showed statistically significant differences between the four groups (p=0.05). Pairwise group comparisons revealed significant differences between groups 1 and 3 and groups 1 and 4 (p=0.005). Conclusion: Biaxial microincision cataract surgery with an incision size of 1.6 mm resulted in the least SIA. Enlargement of the corneal incision beyond 2.0 mm during IOL implantation led to significant increases in SIA. We believe that with the development and dissemination of IOLs which can be inserted through small corneal incisions, biaxial microincision cataract surgery will be the best choice to prevent SIA and increase visual acuity.Yayın Evaluation of intrastromal corneal ring segments for treatment of keratoconus with a mechanical implantation technique(WOLTERS KLUWER MEDKNOW PUBLICATIONS, 2013) Tunc, Zeki; Helvacioglu, Firat; Sencan, SadikPurpose: To evaluate the clinical outcomes of intrastromal corneal ring segment (ICRS) implantation in patients with keratoconus using a mechanical implantation technique. Materials and Methods: Thirty eyes of 17 patients with keratoconus were enrolled. ICRSs (Keraring) were implanted after dissection of the tunnel using Tunc's specially designed dissector under suction. A complete ophthalmic examination was performed, including uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), spherical equivalent, keratometric readings, inferosuperior asymmetry index (ISAI), and ultrasound pachymetry. All 3-, 6-, and 12-month follow-ups were completed, and statistical analysis was performed. Results: The mean preoperative UDVA for all eyes was 1.36 +/- 0.64 logMAR. At 12 months, the mean UDVA was 0.51 +/- 0.28 logMAR (P = 0.001), and the mean preoperative CDVA was 0.57 +/- 0.29 logMAR, which improved to 0.23 +/- 0.18 (P = 0.001) at 1 year. There was a significant reduction in spherical equivalent refractive error from -6.42 +/- 4.69 diopters (D) preoperatively to -1.26 +/- 1.45 D (P = 0.001) at 1 year. In the same period, the mean K-readings improved from 49.38 +/- 3.72 D to 44.43 +/- 3.13 D (P = 0.001), and the mean ISAI improved from 7.92 +/- 3.12 to 4.21 +/- 1.96 (P = 0.003). No significant changes in mean central corneal thickness were observed postoperatively. There were no major complications during and or after surgery. Conclusion: ICRS implantation using a unique mechanical dissection technique is a safe and effective treatment for keratoconus. All parameters improved by the 1-year follow-up.Yayın Evaluation of intrastromal corneal ring segments for treatment of post-LASIK ectasia patients with a mechanical implantation technique(WOLTERS KLUWER MEDKNOW PUBLICATIONS, 2011) Tunc, Zeki; Helvacioglu, Firat; Sencan, SadikAim: To evaluate the clinical outcomes of Keraring segment implantation in patients with post-laser-assisted in situ keratomileusis (LASIK) ectasia, using a mechanical implantation technique. Materials and Methods: Twelve eyes of 10 patients with post-LASIK ectasia were enrolled. Intracorneal ring segments (ICRS) were implanted aft er dissection of the tunnel using Tunc's specially designed dissector under suction. A complete ophthalmic examination was performed, including uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), spherical equivalent, keratometric (K) readings, inferosuperior asymmetry index (ISAI), and ultrasound pachymetry. All 3, 6, and 12-month follow-ups were completed, and statistical analysis was performed. Results: The mean preoperative UDVA for all eyes was 1.28 +/- 0.59 logMAR. At 12 months, the mean UDVA was 0.36 +/- 0.19 logarithm of the Minimum Angle of Resolution (logMAR) (P=0.002), and the mean preoperative CDVA was 0.58 +/- 0.3 logMAR, which improved to 0.15 +/- 0.12 (P=0.002) at 1 year. There was a significant reduction in cylindrical refractive and spherical equivalent refractive error from -5.29 +/- 2.47 diopters (D) and -5.54 +/- 5.04 D preoperatively to -1.47 +/- 0.71 D and -0.74 +/- 1.07 D (P=0.001, P=0.002), respectively, at 1 year. In the same period, the mean K-readings improved from 47.93 +/- 4.84 D to 40.87 +/- 2.36 D (P=0.002), and the mean ISAI improved from 5.34 +/- 3.05 to 2.37 +/- 1.68 (P=0.003). No significant changes in mean central corneal thickness were observed postoperatively. There were no major complications during or aft er surgery. Conclusion: ICRS implantation using a unique mechanical dissection technique is a safe and effective treatment for post-LASIK ectasia. All parameters showed improvement at 1-year follow-up.Yayın Outcomes of torsional microcoaxial phacoemulsification performed by 12-degree and 22-degree bent tips(ELSEVIER SCIENCE INC, 2013) Helvacioglu, Firat; Yeter, Celal; Tunc, Zeki; Sencan, SadikPURPOSE: To compare the safety and efficacy of Ozil Intelligent Phaco torsional microcoaxial phacoemulsification surgeries performed with 12-degree and 22-degree bent tips using the Infiniti Vision System. SETTING: Maltepe University School of Medicine Department of Ophthalmology, Istanbul, Turkey. DESIGN: Comparative case series. METHODS: Eyes were assigned to 2.2 mm microcoaxial phacoemulsification using the torsional mode with a 22-degree bent tip (Group 1) or a 12-degree bent tip (Group 2). The primary outcome measures were ultrasound time (UST), cumulative dissipated energy (CDE), longitudinal and torsional ultrasound (US) amplitudes, mean surgical time, mean volume of balanced salt solution used, and surgical complications. RESULTS: Both groups included 45 eyes. The mean UST, CDE, longitudinal US amplitude, and torsional US amplitude were 65 seconds +/- 27.23 (SD), 11.53 +/- 6.99, 0.22 +/- 0.26, and 42.86 +/- 15.64, respectively, in Group 1 and 84 +/- 45.04 seconds, 16.68 +/- 10.66, 0.48 +/- 0.68, and 46.27 +/- 14.74, respectively, in Group 2. The mean UST, CDE, and longitudinal amplitudes were significantly lower in Group 1 (P=.003, P=.008, and P=.022, respectively). The mean volume of balanced salt solution was 73.33 +/- 28.58 cc in Group 1 and 82.08 +/- 26.21 cc in Group 2 (P=.134). CONCLUSION: Torsional phacoemulsification performed with 22-degree bent tips provided more effective lens removal than 12-degree bent tips, with a lower UST and CDE.Yayın Outcomes of torsional microcoaxial phacoemulsification using tips with 30-degree and 45-degree aperture angles(ELSEVIER SCIENCE INC, 2014) Helvacioglu, Firat; Sencan, Sadik; Yeter, Celal; Tunc, Zeki; Uyar, O. MuratPURPOSE: To compare the safety and efficacy of Ozil Intelligent Phaco torsional microcoaxial phacoemulsification surgeries performed using 30-degree and 45-degree aperture angled tips. SETTING: Maltepe University School of Medicine Department of Ophthalmology, Istanbul, Turkey. DESIGN: Comparative case series. METHODS: Eyes were assigned to 2.2 mm microcoaxial phacoemulsification using the torsional mode with a 45-degree (Group 1) or 30-degree (Group 2) aperture angled tip. A quick-chop surgical technique was used. The primary outcome measures were ultrasound time (UST), cumulative dissipated energy (CDE), longitudinal and torsional ultrasound (US) amplitudes, mean surgical time, mean balanced salt solution volume used, and mean central corneal thickness (CCT) changes. RESULTS: The mean UST, CDE, and longitudinal and torsional US amplitudes were 58.21 seconds +/- 33.81 (SD), 7.74 +/- 6.23, 0.45 +/- 0.30, and 26.30 +/- 12.60 in Group 1 and 63.83 +/- 23.42 seconds, 12.36 +/- 6.75, 0.23 +/- 0.26, and 44.65 +/- 14.38 in Group 2, respectively. The mean CDE and torsional amplitudes were significantly lower in Group 1 (P=.002 and P=.001, respectively). The mean balanced salt solution volume was 73.30 +/- 19.87 cc in Group 1 and 74.30 +/- 19.44 cc in Group 2 (P=.821). The mean CCT change was 52.40 +/- 38.08 mu m and 99.35 +/- 47.14 mu m, respectively (P<.001). CONCLUSION: Torsional phacoemulsification performed with a 45-degree aperture angled tip provided more effective lens removal with a lower CDE and less CCT change than a 30-degree aperture angled tip.Yayın Ozil IP torsional mode versus combined torsional/longitudinal microcoaxial phacoemulsification(WICHTIG EDITORE, 2012) Helvacioglu, Firat; Tunc, Zeki; Yeter, Celal; Oguzhan, Hasan; Sencan, SadikPURPOSE. To compare the safety and efficacy of microcoaxial phacoemulsification surgeries performed with the Ozil Intelligent Phaco (IP) torsional mode and combined torsional/longitudinal ultrasound (US) mode using the Infiniti Vision System (Alcon Laboratories). METHODS. In this prospective randomized comparative study, 60 eyes were assigned to 2.2-mm microcoaxial phacoemulsification using the Ozil IP torsional mode (group 1) or combined torsional/longitudinal US mode (group 2). The primary outcome measures were US time (UST), cumulative dissipated energy (CDE), longitudinal and torsional ultrasound amplitudes, mean operation time, mean volume of balanced salt solution (BSS) used, and surgical complications. RESULTS. Both groups included 30 eyes. Mean UST, CDE, and longitudinal and torsional ultrasound amplitudes in group 1 were 1 minute 15 +/- 34.33 seconds, 8.74 +/- 5.64, 0.43 +/- 0.74, and 25.56 +/- 8.56, respectively, and these parameters in group 2 were 1 minute 40 +/- 51.44 seconds, 9.28 +/- 5.99, 3.64 +/- 1.55, and 3.71 +/- 1.34, respectively. UST and longitudinal amplitudes were found to be significantly low in group 1 (p<0.001, p<0.001), whereas torsional amplitude was found to be significantly high in this group (p=0.001). Mean volumes of BSS used in groups 1 and 2 were 63.30 +/- 18.00 cc and 84.50 +/- 28.65 cc, respectively (p=0.001). CONCLUSIONS. The Ozil IP torsional mode may provide more effective lens removal than the combined torsional/longitudinal US mode with a lower UST and volume of BSS used.