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Yayın The comparative evaluation of apoptosis produced by leuprolide or orchiectomy on rat prostate tissue(PAGEPRESS PUBL, 2015) Cakiroglu, Basri; Hazar, Aydin Ismet; Eyyupoglu, Seyit Erkan; Balci, Mustafa Bahadir Can; Sinanoglu, Orhun; Tuzlali, PinarIntroduction: Organisms are constantly in a balance meaning that while new cells are produced, some of the older ones die which takes place in 2 ways: necrosis or apoptosis. Apoptosis is the programmed cellular death triggered by intrinsic or extrinsic stimuli. In this study we have evaluated the apoptosis of prostate tissue generated by surgical or medical orchiectomy. Material and Method: In this experimental study, we used 36 adult male rats that were evaluated in 3 groups. The first group (Group 1) consisted of 12 rats that had bilateral orchiectomy; the second group (Group 2) included 12 rats that were given leuprolide acetate and the third group (Group 3) consisted of 12 control rats. Immunohistochemical staining of the prostate of all rats was performed and the presence of glandular atrophy and apoptosis were evaluated in the three groups. The statistical differences between the two groups were evaluated by the Fisher exact test. Results: Glandular atrophy was not determined in any rat of the control group, and the apoptotic staining was in the normal limits in all the control rats. In Leuprolide group, glandular atrophy was mild in 7 cases, and moderate in 3 rats. In 2 rats of the Leuprolide group, atrophy was not demonstrated. In surgical orchiectomy group, glandular atrophy was present in all cases. Atrophy was observed as cystic atrophy. Statistical analysis with the Fisher exact test revealed that glandular atrophy was statistically significantly more common in surgical orchiectomy group compared with Leuprolide group (p = 0,012). Conclusion: If the aim of treatment in androgen dependent prostatic adenocarcinoma or benign prostate hypertrophy is the construction of a robust apoptosis, bilateral orchiectomy generates a more powerful apoptosis compared with Leuprolide.Yayın Comparison of transurethral incision of the prostate and silodosin in patients having benign prostatic obstruction in terms of retrograde ejaculation(PAGEPRESS PUBL, 2017) Cakiroglu, Basri; Hazar, Aydin Ismet; Sinanoglu, Orhun; Arda, Ersan; Ekici, SinanBackground: To compare the functional outcomes and retrograde ejaculation (RE) after transurethral incision of the prostate (TUIP) or silodosin in bladder outlet obstruction (BOO) secondary to a small prostate. Methods: Prospectively collected data from December 2011 through December 2014 of 192 LUTS patients having fertility concerns with prostate volume smaller than 40 ml receiving either TUIP or silodosin treatment were prospectively reviewed. The treatment outcomes were evaluated and compared. Results: TUIP was performed in 96 cases and silodosin 8 mg was prescribed in 96 cases. At 12th months after TUIP or continuous silodosin treatment, the decrease in mean International Prostate Symptom Score (IPSS) and postvoiding residual urine (PVR) and the improvement of mean maximal flow rate (Q(max)) were significant (p = 0.000). The improvement in IPPS and Qmax was significantly higher in TUIP group compared to silodosin group (p = 0.005, p = 0.000) with a lower rate of retrograde ejaculation (RE) in TUIP group. (11/96 vs 33/96) (p = 0.000) Conclusions: Both TUIP and silodosin ensures comparable improvement in PVR, IPSS and Q(max) with a lower rate of RE on the TUIP group in prostates weighing less than 40 grams suggesting that TUIP is a better choice in younger patiens seeking preservation of ejaculation with fertility concerns.Yayın The histology and the proapoptotic control in the ipsilateral and the contralateral testes following unilateral vasectomy(PAGEPRESS PUBL, 2015) Hazar, Aydin Ismet; Cakiroglu, Basri; Sakalli, Ertan; Balci, Mustafa Bahadir Can; Eyyupoglu, Erkan; Tas, Tuncay; Sinanoglu, Orhun; Tuzlali, Pinar; Cilesiz, Nusret CanObjective: The aim of this study was to enlighten both the testicular histology and the genetic aspects of the apoptotic process. Thus an experimental study was designed with a model of unilateral vasectomy. Methods: Twenty-two adult male rats were used and 4 main groups were formed. The first (A), the second (B), the third (C), and the fourth group (D) consisted of 4, 4, 4 and 10 rats respectively. Rats in group A had sham operation while rats in other groups (B, C, D) underwent left vasectomy operation including binding of ductus deferens with a 3/0 silk and cutting a minimum of 1 cm part while preserving the vascular structure under 9x magnification. Rats undergoing unilateral vasectomy were sacrificed at the 1st, 2nd and 8th weeks and their testicular structure and proapoptotic gene proteins were compared with that of the control group undergoing sham operation. Results: We found that vasectomy gradually caused destruction and both ipsilateral and contralateral testicles were affected showing initial apoptosis. Conclusion: The procedure causes destruction in the testicular structure by causing bilateral intratubular germ cell necrosis, unilateral obstruction, increase in the tubular pressure and processes that are aggravated by some probable autoimmune reactions.Yayın Monosymptomatic nocturnal enuresis caused by seasonal temperature changes(E-CENTURY PUBLISHING CORP, 2014) Tas, Tuncay; Cakiroglu, Basri; Hazar, Aydin Ismet; Balci, Mustafa Bahadir Can; Sinanoglu, Orhun; Nas, Yunus; Yilmazer, FazliBackground: Primary nocturnal enuresis is the most frequent urologic complaint among pediatric patients. Enuresis is believed to have a complex etiology involving genetic, somatic, and behavioral factors. We study the relationship between seasonal temperature changes effect and monosymptomatic nocturnal enuresis (MNE). Methods: Between 2011 and 2012, a total of 75 children with primary MNE selected from urology and pediatry clinics were included in this study. All of the children underwent physical examinations, urine analyses, urinary ultrasounds, and direct urinary graphs. We evaluated the enuresis ratio for the summer (the hot season from June to September) and winter (the cold season from December to March) months in nightly, weekly, and monthly intervals via prepared questionnaires. Results: Of the 75 study participants, 45 were boys (60%) and 30 were girls (40%). The age range was 6-16 years (mean 10.3 +/- 2.0 years). We observed a difference in the ratio of enuresis data between the summer and winter months in 29 males and 19 females, which totals 48 of the 75 MNE patients evaluated in this study. There was a statistically significant difference noted in monthly enuresis ratio in the summer and winter (p<0.0001). We observed a significant difference in quality of life, and this difference caused considerable emotional discomfort for the patients. Conclusion: In the winter months, the nightly, weekly, and monthly ratios are higher in children with MNE. This increase causes a decrease in the quality of life of these children.Yayın Penile Mondor's Disease Induced by Vigorous Sexual Activity: Two Cases, Two Different Approaches(ORTADOGU AD PRES & PUBL CO, 2012) Aydin, Memduh; Tas, Tuncay; Gursoy, Gokhan; Sinanoglu, Orhun; Balci, Mustafa Bahadir Can; Hazar, Aydin Ismet; Nuhoglu, BarisPenile Mondor's disease is a painless superficial induration due to thrombosis of penile superficial dorsal vein. Etiological factors for superficial dorsal penile vein thrombosis include trauma, vigorous sexual activity, pelvic tumors and a distended bladder. Doppler ultrasonographic evidence of thrombotic dorsal penile vein is diagnostic for penile Mondor's disease. Two cases with Mondor's disease of the penis due to brutal sexual intercourse are reported here. The first patient's thrombosis resolved spontaneously whereas in the second one anti-inflammatory and heparinoid agents were applied. The treatment should primarily be based on temporary sexual abstinence, and in case of no response treatment with non-steroid anti-inflammatory agents, local anticoagulants should be administered. Larger series are needed to determine whether initial observation is appropriate for all patients with penile Mondor's disease.
