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Yayın Correlation between breast density in mammography and background enhancement in MR mammography(SPRINGER, 2010) Cubuk, R.; Tasali, N.; Narin, B.; Keskiner, F.; Celik, L.; Guney, S.Purpose. We aimed to analyse the influence of mammographic breast density on background enhancement (BE) at magnetic resonance (MR) mammography in pre- and postmenopausal women. In addition, we questioned predictability of contrast-enhancement dynamics of normal fibroglandular tissue (NFT) at MR mammography according to mammographic breast density. Materials and methods. Twenty-six patients (mean age 51.54 +/- 11.5 years; range 37-79 years) who underwent both MR mammography and conventional mammography were included in this retrospective study. Fourteen patients were premenopausal and 12 were postmenopausal. The ethics committee of our institution approved the study. The mammograms were retrospectively reviewed for overall breast density according to the four-point scale (I-IV) of the Breast Imaging Reporting and Data System (BI-RADS) classification. Two radiologists, who were unaware of the clinical data, separately assessed the MR mammography images. Images were assessed for enhancement kinetic features (enhancement kinetic curve and the early-phase enhancement rate) and BE. MR mammography and conventional mammography findings were compared according to BI-RADS breast density category and menopausal status. Results. Percentage of increased signal intensity values during the first minute did not change according to mammographic breast density, and the mean early-phase enhancement rate scores were similar among breast density groups (p=0.942). There was no significant difference between pre- and postmenopausal groups. Enhancement kinetic features of the different groups based on BI-RADS breast density category and menopausal status were similar. There was no correlation between breast density and BE in either premenopausal (p=0.211) or in postmenopausal (p=0.735) groups. Conclusions. We determined no correlation between mammographic breast density and so-called BE in MR mammography in either premenopausal or postmenopausal women. NFT at MR mammography cannot be predicted on the basis of mammographic breast density.Yayın Effect of an oral anxiolytic medication and heart rate variability on image quality of 64-slice MDCT coronary angiography(SPRINGER, 2011) Cubuk, R.; Tasali, N.; Yilmazer, S.; Gokalp, P.; Celik, L.; Dagdeviren, B.; Guney, S.The aim of the study was to investigate the relationship between image quality in 64-slice multidetector computed tomography (MDCT) and patients' preimaging anxiety status and heart rate variability (HRV), and to evaluate the efficacy of an orally administered anxiolytic medication on HRV and image quality. Sixty patients [14 women, 46 men; mean age 52.53 +/- 10.55 (SD), range 33-78 years] were studied. Anxiety levels were assessed with the State-Trait Anxiety Inventory 60 min before the procedure. The participating patients were randomly assigned to one of the two study groups: a control group (no medication administered for anxiety reduction) and an anxiolytic medication group, with 30 patients in each group. The presence of motion artefacts and image quality for each coronary artery segment were evaluated using a four-point grading system. To estimate HRV, the duration of each heartbeat during MDCT data acquisition was measured in each patient. A moderate correlation was found between HRV during MDCT scanning and the mean image quality for all coronary segments (r=0.47, p < 0.01). There was an association between HRV and state anxiety scores in all cases (r=0.370, p < 0.01). HRV in the patients who received alprazolam was statistically significantly lower than in controls (p < 0.05). The average image quality in patients who used alprazolam was also statistically significantly higher than in controls (p < 0.05). The most important finding in our study is that oral premedication to reduce anxiety is also effective in decreasing HRV and improves image quality. Therefore, we suggest that using alprazolam in addition to a beta-blocker may improve image quality in patients undergoing MDCT coronary angiography (MDCT-CA). Anxiolytic usage may improve image quality by lowering the HRV in selected cases where administration of a beta-blocker is contraindicated. We also suggest that further studies in larger series are required to validate this finding.Yayın A giant villous adenoma: case mimicking rectosigmoid malignancy; radiological survey to diagnosis.(2010) Çubuk, R.; Tasali, N.; Arslan, G.; Midi, A.; Manukyan, Manuk Norayık; Guney, S.Villous adenomas are benign lesions, which are difficult to interpret because of their malignancy potential. They have similar radiological findings to malignant lesions. Usually, villous adenomas are asymptomatic although they may cause rectal bleeding like malignant tumours. We present a case of giant villous adenoma to evaluate the contribution of its radiological features including double contrast barium enema, computed tomography and magnetic resonance imaging examinations for the differential diagnosis.Yayın Is bone mineral density measurements correlated with facet joint orientation? A dual energy X-ray absorptiometry study.(2009) Çubuk, R.; Tasali, N.; Kozakcioglu, M.; Guney, S.We aimed to study correlation between bone mineral density (BMD) and facet joint orientation in normal, osteopenic and osteoporotic patients. The correlation between more sagittally oriented facet joint and facet joint osteoarthritis and spondylolisthesis was described previously. However, the correlation between facet joint orientation and its possible correlation with BMD measurements has not been evaluated. Our study is a primary effort to describe the correlation of BMD with facet joint orientation, which is important in terms of spinal biomechanics. Thirty-seven patients who had undergone both lumbar spinal Magnetic Resonance Imaging and Dual-energy X-ray absorptiometry were included in the study. Facet joint osteoarthritis and orientation were evaluated in five levels between L1-S1. For facet joint orientation, axial images were used. For grading of facet joint osteoarthritis the classification of Weishaupt and co-workers were used. Lumbar BMD was correlated with BMD of the hip. Facet orientation was similar among the 3 groups namely patients with normal BMD values, osteopenia and osteoporosis. Facet orientation was not correlated with lumbar BMD measurements. Facet joint orientation is not correlated with BMD measurements in our patient group without spondylolisthesis. Since spondylolisthesis has been demonstrated to alter BMD measurements, we suggest that spinal degenerative disease secondary to spondylolisthesis is the main entity leading to measurement errors.
