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    Association between apolipoprotein E genotypes and panic disorder in Turkish population
    (TAYLOR & FRANCIS LTD, 2019) Gulec-Yilmaz, Seda; Gulec, Huseyin; Ogut, Dicle Bilge; Cetin, Bugra; Gormus, Uzay; Isbir, Turgay
    Aim: In this study, we aimed to investigate possible interactions among the apolipoprotein E (ApoE) and panic disorder (PD), taking into account serum cholesterol levels and subfractions.Methods: ApoE genotyping was performed by real-time polymerase chain reaction in DNA samples of PD patient group (n=45) and healthy control group (n=50). The serum lipid levels, low-density lipoprotein (LDL), and high-density lipoprotein (HDL) subfraction analysis were examined.Results: There was a significant difference of ApoE genotypes in patient and control groups. The E3/E3 genotypes lower whereas E4 allele carriers were significantly higher in PD group ApoE4allele carriers had 3.2-fold higher risk of PD. PD group had significantly lower LDL and HDL levels. In spite of the decreased levels of total LDL, antiatherogenic large LDL subgroup was significantly lower in a patient with PD. Antiatherogenic large HDL and Intermediate HDL levels were lower, while atherogenic small HDL subfraction was significantly higher in PD group. Furthermore, Apo E3/E3 genotype carriers had significantly higher large LDL, HDL, large HDL, intermediate HDL level, and also had highest HDL between all the groups. ApoE4 allele carriers while they had highest atherogenic small HDL level.Conclusion: E4 allele can be associated with PD as an eligible risk factor, the E3/E3 could be a risk-reducing factor for PD. Patients with PD not only had lower LDL and HDL levels but also they have higher atherogenic LDL and HDL subfractions. Also, E3/E3 genotype carriers had convenient but ApoE4 carriers had atherogenic plasma cholesterol levels and subfractions.
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    Dissociation in bipolar disorder: Relationships between clinical variables and childhood trauma
    (ELSEVIER SCIENCE BV, 2015) Hariri, Aytul Gursu; Gulec, Medine Yazici; Orengul, Fatma Fariha Cengiz; Sumbul, Esra Aydin; Elbay, Rumeysa Yeni; Gulec, Huseyin
    Objective: The dissociative experiences of patients with bipolar disorder (BD) differ from those of patients with other psychiatric disorders with regard to certain features. The primary goal of this study was to evaluate the relationship between the clinical variables of BD and childhood trauma using the factor structure, psychometric features, and potential subdimensions of the Dissociative Experience Scale (DES). Method: This study included 200 BD patients who were in a remission period and 50 healthy volunteers. The BD patients were recruited from two psychiatry clinic departments in Turkey. The sociodemographic data of the two groups and their scores on the DES and Childhood Trauma Questionnaire (CTQ)-28 were compared. Results: The overall DES scores and the scores for each DES item accurately and reliably measured dissociation in the BD patients (item total correlation r scores: > 0.20, Cronbach's alpha: 0.95), and a factor analysis revealed two subdimensions of the DES for BD: identity confusion/alteration (SubDES-1) and amnesia and clepersonalizaLion/clerealizaLion (SubDES-2). Although age at onset of ED was significantly correlated with both subdimensions, illness duration was significantly correlated only with the SubDES2. 01 all the subjects, 19.5% (39/200 patients) were identified as having dissociative experiences by the DES-Taxon (DES-T), and subjects in this subscale (DES-T-positive) had significantly higher total scores on the CTQ-28 as well as higher scores on each subgroup of this scale. The highest CTQ-28 subgroup score was emotional neglect, which was followed by emotional abuse and physical neglect and then sexual abuse and physical abuse. There was a significant correlation between total scores on the CTQ-28 and SubDES-2 but none of the CTQ-28 subscale scores was significantly correlated with either SubDES-1 or Sub DES-2. Conclusion: The DES sufficiently and reliably identified the experience of dissociative symptoms on the part of BD patients, and a factor analysis revealed two subdimensions of BD on this scale. In particular, DES-T-positive subjects experienced a greater amount of childhood trauma and, as a result, had an earlier age at onset of BD. Additionally, SubDES-2, which was associated with amnesia and depersonalization/derealization, was closely related to illness duration. (C) 2015 Elsevier B.V. All rights reserved.
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    The effect of cluster B personality disorder comorbidity on the coping styles in patient with bipolar disorder
    (CUMHURIYET UNIV TIP FAK PSIKIYATRI ANABILIM DALI, 2015) Usta, Haluk; Gulec, Huseyin; Hariri, Aytul Gursu; Gulec, Medine
    Objective: The effect of the presence of cluster B personality disorders which are frequent comorbidities with bipolar I disorder on the coping strategies was investigated and also it was studied whether there was a different profile. Methods: The patients who were in remission period and had bipolar disorder were included in the study. All things considered, we included 50 male and 50 female patients who had bipolar I disorder in remission period with cluster B personality disorder, and 50 male and 50 female patients without cluster B personality disorder. SCID-I and SCID-II were used respectively. The COPE scale was also given to determine patients' coping styles. Results: In terms of coping styles, the patients with cluster B personality disorder had higher dysfunctional coping styles scores. There were no significant differences for problem-focused coping scores, and emotion-focused coping scores among those patients. When the subscales were examined, the scores of focusing on emotions and expressing emotions, denial, retraining, and substance use subscales were higher among the patients with cluster B personality disorder. Conclusion: When the coping styles of bipolar patient groups those were divided according to having cluster B personality disorder or not were compared, it was seen that the group with cluster B personality disorder were using more dysfunctional coping styles. These findings can be important with regards to psychosocial interventions. Our findings must be replicated with larger and different comorbidity groups.
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    Personality organization in obsessive compulsive disorder with and without insight
    (CUKUROVA UNIV, FAC MEDICINE, 2019) Giynas, Fikret Ferzan; Kizilkurt, Ozlem Kazan; Gulec, Medine Yazici; Gulec, Huseyin
    Purpose: The aim of this study was to investigate personality organization level in patients with and without insight of Obsessive Compulsive Disorder (OCD). Materials and Methods: We conducted a cross-sectional study in Erenkoy Psychiatry and Neurological Diseases Training and Research Hospital. The study's universe consisted of 100 patients who applied with OCD diagnosis to Anxiety Policlinic of our hospital. Sociodemographic data form and Yale Brown Obsessive-Compulsive scale (Y-BOCS) Personality Organization Diagnostic Form (PODF) was completed for each participant at the first interview. Results: The proportion of patients with poor insight group in our study was 23%. Significant differences were found between the Y-BOCS general severity scores of the groups.The patients in two groups achieved significantly different total scores in identity, scores in primitive and mature defense mechanisms and reality testing. There was significant difference between patients with good insight OCD and poor insight OCD in terms of general personality organization. The total score of PODF identity had a predictive effect on insight in the linear direction. Conclusion: The present study indicated that patients with poor insight OCD had lower level of personality organization as compared to patients with good insight OCD. According to the scores obtained in the subscales of PODF, patients with poor insight OCD showed high diffusion identity as compared to patients with good insight OCD. Besides this, it was observed that the group with poor insight mostly used primitive defense mechanisms, their reality testing was relatively disturbed and they had low level of object relations.