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    Assessment of Probe-to-Specimen Distance Effect in Kidney Stone Treatment With Hydrodynamic Cavitation
    (ASME, 2015) Uzusen, Dogan; Demir, Ebru; Perk, Osman Yavuz; Oral, Ozlem; Ekici, Sinan; Unel, Mustafa; Gozuacik, Devrim; Kosar, Ali
    The aim of this study is to focus on the effect of probe-to-specimen distance in kidney stone treatment with hydrodynamic bubbly cavitation. Cavitating bubbles were generated by running phosphate buffered saline (PBS) through stainless steel tubing of inner diameter of 1.56 mm at an inlet pressure of similar to 10,000 kPa, which was connected to a 0.75 mm long probe with an inner diameter of 147 mu m at the exit providing a sudden contraction and thus low local pressures. The bubbles were targeted on the surface of nine calcium oxalate kidney stones (submerged in a water pool at room temperature and atmospheric pressure) from three different distances, namely, 0.5 mm, 2.75 mm, and 7.75 mm. The experiments were repeated for three different time durations (5 min, 10 min, and 20 min). The experimental data show that amongst the three distances considered, the distance of 2.75 mm results in the highest erosion amount and highest erosion rate (up to 0.94 mg/min), which suggests that a closer distance does not necessarily lead to a higher erosion rate and that the probe-to-specimen distance is a factor of great importance, which needs to be optimized. In order to be able to explain the experimental results, a visualization study was also conducted with a high speed CMOS camera. A new correlation was developed to predict the erosion rates on kidney stones exposed to hydrodynamic cavitation as a function of material properties, time, and distance.
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    Hydrodynamic cavitation kills prostate cells and ablates benign prostatic hyperplasia tissue
    (ROYAL SOC MEDICINE PRESS LTD, 2013) Itah, Zeynep; Oral, Ozlem; Perk, Osman Yavuz; Sesen, Muhsincan; Demir, Ebru; Erbil, Secil; Dogan-Ekici, A. Isin; Ekici, Sinan; Kosar, Ali; Gozuacik, Devrim
    Hydrodynamic cavitation is a physical phenomenon characterized by vaporization and bubble formation in liquids under low local pressures, and their implosion following their release to a higher pressure environment. Collapse of the bubbles releases high energy and may cause damage to exposed surfaces. We recently designed a set-up to exploit the destructive nature of hydrodynamic cavitation for biomedical purposes. We have previously shown that hydrodynamic cavitation could kill leukemia cells and erode kidney stones. In this study, we analyzed the effects of cavitation on prostate cells and benign prostatic hyperplasia (BPH) tissue. We showed that hydrodynamic cavitation could kill prostate cells in a pressure- and time-dependent manner. Cavitation did not lead to programmed cell death, i.e. classical apoptosis or autophagy activation. Following the application of cavitation, we observed no prominent DNA damage and cells did not arrest in the cell cycle. Hence, we concluded that cavitation forces directly damaged the cells, leading to their pulverization. Upon application to BPH tissues from patients, cavitation could lead to a significant level of tissue destruction. Therefore similar to ultrasonic cavitation, we propose that hydrodynamic cavitation has the potential to be exploited and developed as an approach for the ablation of aberrant pathological tissues, including BPH.
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    Visualization of microscale cavitating flow regimes via particle shadow sizing imaging and vision based estimation of the cone angle
    (ELSEVIER SCIENCE INC, 2016) Ghorbani, Morteza; Alcan, Gokhan; Unel, Mustafa; Gozuacik, Devrim; Ekici, Sinan; Uvet, Huseyin; Sabanovic, Asif; Kosar, Ali
    Recent studies show the destructive effect of the energy released from the collapse of cavitation bubbles, which are generated in micro domains, on the targeted surfaces. The cavitation phenomenon occurs at low local pressures within flow restrictive elements and strongly affects fluid flow regimes inside microchannels which results in spray formation. Extended cavitation bubbles toward the outlet of the microchannel, droplet evolution, and spray breakup are among crucial mechanisms to be considered in spray structure. In this study, various spray structures under the effect of hydrodynamic cavitation were recorded using a high speed visualization system. Acquired images were analyzed and characterized using several image processing algorithms. In this regard, the fluid flow with ascending upstream pressures from 10 to 120 bar were passed through a microchannel with an inner diameter of 0.152 mm. The spray at the outlet of the microchannel was analyzed for these pressures in four different segments. Particle Shadow Sizing (PSS) imaging and several image processing techniques such as contrast stretching, thresholding and morphological operations were employed to identify the flow regimes in the separated segments. In addition, a vision based estimation technique that utilizes a Kalman filter was developed to estimate cone angle of the spray. Furthermore, classification of fluid flow regimes and morphological characteristics of the spray structure were outlined based on the cavitation number. (C) 2016 Published by Elsevier Inc.