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    Comparison of Bone Prefabrication with Vascularized Periosteal Flaps, Hydroxyapatite, and Bioactive Glass in Rats
    (THIEME MEDICAL PUBL INC, 2015) Ersoy, Burak; Bayramicli, Mehmet; Ercan, Feriha; Sirinoglu, Hakan; Turan, Pinar; Numanoglu, Ayhan
    Background Periosteal flaps possess osteoprogenitor cells and an osteoinductive potential that can be further augmented by combination with a biodegradable scaffold; therefore, various osteoconductive and osteostimulative biomaterials are frequently combined with periosteal flaps in studies of bone prefabrication. An experimental study was designed to determine and compare the contribution of bioactive glass and hydroxyapatite to osteoneogenesis in rats when combined with a periosteal flap. Materials and Methods In 60 Sprague Dawley rats, saphenous artery periosto-fasciocutaneous island flaps were transposed to abdomen. In group 1, the flap was left alone, in group 2, an empty artificial pocket made of Gore-Tex (W. L. Gore & Associates, Inc.; Flagstaff, AZ) was sutured onto the periosteal layer, and in groups 3 and 4, the pocket was filled with bioactive glass and hydroxyapatite, respectively. Following sampling for histological analysis, a 4-point scoring system was used to grade inflammatory cell infiltration, osteogenesis, angiogenesis, and cell migration into the bioactive material. Results The combination of the periosteal flap with any of the bioactive materials resulted in significantly higher percentages of animals exhibiting osteogenesis (80% in hydroxyapatite group and 93.3% in the bioactive glass group; p = 0.0000528) and angiogenesis. Comparison of the bioactive material groups revealed that a significantly higher proportion of animals in the bioactive glass group exhibited moderate or severe inflammation (80 vs. 20%; p = 0.002814). Conclusion Periosteal flaps prefabricated with hydroxyapatite or bioactive glass in rats exhibit osteogenic capacities that are not dependent on direct bone contact or proximity to vascular bony tissue. The innate capacity of the periosteal flap when utilized alone for osteoneogenesis was found to be rather insufficient.
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    Karbondioksitsiz ortamda ve düşük ısıda canlı kalabilen Hepg2 hücrelerinin morfolojik özellikleri.
    (Türk Elektron Mikroskopi Derneği, 2013) Güney, Gülşah; Tok, Olgu Enis; Ercan, Feriha
    HepG2 hücreleri, normal karaciğer fonksiyonları ve kanser tedavisi ile ilgili çalışmalarda en çok kullanılan hücre dizilerinden birisidir. Bu hücrelerin birçok hücre dizisi gibi 37?C da ve %5 CO2’li ortamda fonksiyonlarını en üst düzeyde sürdürebildiği bildirilmiştir. Farklı ısılarda bu hücrelerin bazı enzimatik özelliklerini inceleyen çalışmalar bulunmasına rağmen, düşük ısıda ve karbondioksitsiz ortamda kalan HepG2 hücrelerinin davranışlarını inceleyen bir araştırmaya rastlanmamıştır. Çalışmamızda, bu şekildeki bir stres ortamında kalan bu kanser hücrelerinin morfolojik özelliklerindeki değişimi ve bu hücrelerden canlı kalabilenlerin yeniden normal kültür ortamına uyumunun nasıl olduğunu incelemeyi amaçladık.