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Acil serviste renal kolik tanı ve tedavisi
(Maltepe Üniversitesi, 2010) Sinanoğlu, Orhun; Ekici, Sinan; Uraz, Mahmure; Çubuk, Rahmi
Renal kolik(RK) acil serviste rastlanan bir hastalıktır. RK'nin en sık nedeni üreter taşıdır. Ürolitiyaz tedavisinde acil hekimi ilk rolü oynamaktadır. Bu makalede renal kolik yaklaşımında günümüzde kabul gören biyokimyasal değerlendirme, görüntüleme, ağrı ve spesifik tedaviler değerlendirilmektedir. Renal kolik hastalarının çoğu kuvvetli ağrı kesici tedavisine ve üroloji polikliniği takibine gereksinim duymaktadır. Komplike RK üroloji kliniğinde acil tedavi gerektirdiğ inden tanısal araçlar kullanılırken dikkatli olunmalıdır.
Anticancer Use of Nanoparticles as Nucleic Acid Carriers
(AMER SCIENTIFIC PUBLISHERS, 2014) Gozuacik, D.; Yagci-Acar, H. F.; Akkoc, Y.; Kosar, A.; Dogan-Ekici, A. Isin; Ekici, Sinan
Advances in nanotechnology opened up new horizons in the field of cancer research. Nanoparticles made of various organic and inorganic materials and with different optical, magnetic and physical characteristics have the potential to revolutionize the way we diagnose, treat and follow-up cancers. Importantly, designs that might allow tumor-specific targeting and lesser side effects may be produced. Nanoparticles may be tailored to carry conventional chemotherapeutics or new generation organic drugs. Currently, most of the drugs that are commonly used, are small chemical molecules targeting disease-related enzymes. Recent progress in RNA interference technologies showed that, even proteins that are considered to be "undruggable" by small chemical molecules, might be targeted by small RNAs for the purpose of curing diseases, including cancer. In fact, small RNAs such as siRNAs, shRNAs and miRNAs can drastically change cellular levels of almost any given disease-associated protein or protein group, resulting in a therapeutic effect. Gene therapy attempts were failing mainly due to delivery viral vector-related side effects. Biocompatible, non-toxic and efficient nanoparticle carriers raise new hopes for the gene therapy of cancer. In this review article, we discuss new advances in nucleic acid and especially RNA carrier nanoparticles, and summarize recent progress about their use in cancer therapy.
Assessment of Probe-to-Specimen Distance Effect in Kidney Stone Treatment With Hydrodynamic Cavitation
(ASME, 2015) Uzusen, Dogan; Demir, Ebru; Perk, Osman Yavuz; Oral, Ozlem; Ekici, Sinan; Unel, Mustafa; Gozuacik, Devrim; Kosar, Ali
The aim of this study is to focus on the effect of probe-to-specimen distance in kidney stone treatment with hydrodynamic bubbly cavitation. Cavitating bubbles were generated by running phosphate buffered saline (PBS) through stainless steel tubing of inner diameter of 1.56 mm at an inlet pressure of similar to 10,000 kPa, which was connected to a 0.75 mm long probe with an inner diameter of 147 mu m at the exit providing a sudden contraction and thus low local pressures. The bubbles were targeted on the surface of nine calcium oxalate kidney stones (submerged in a water pool at room temperature and atmospheric pressure) from three different distances, namely, 0.5 mm, 2.75 mm, and 7.75 mm. The experiments were repeated for three different time durations (5 min, 10 min, and 20 min). The experimental data show that amongst the three distances considered, the distance of 2.75 mm results in the highest erosion amount and highest erosion rate (up to 0.94 mg/min), which suggests that a closer distance does not necessarily lead to a higher erosion rate and that the probe-to-specimen distance is a factor of great importance, which needs to be optimized. In order to be able to explain the experimental results, a visualization study was also conducted with a high speed CMOS camera. A new correlation was developed to predict the erosion rates on kidney stones exposed to hydrodynamic cavitation as a function of material properties, time, and distance.
Benign mixed epithelial and stromal tumor of the kidney
(HINDAWI LTD, 2006) Ekici, A. Isin Dogan; Ekici, Sinan; Gurel, Bora; Altinok, Gulcin; Erkan, Ilhan; Gungen, Yucel
A 51-year-old, perimenopausal, female patient with 1-month history of right flank pain who was diagnosed with a renal mass and underwent nephron-sparing partial nephrectomy is presented. The renal mass was found to be a benign, biphasic tumor composed of an epithelial component, consisting of ducts of variable size scattered within a mesenchymal component, composed of spindle cells arranged in sheets and fascicles. No atypia, mitosis, or necrosis was found. The spindle component shows desmin, smooth muscle actin, and estrogen and progesterone receptor positivity immunohistochemically. The diagnosis of benign mixed epithelial and stromal tumor of the kidney is rendered. No recurrent disease has been detected during 2 years of follow up.
Böbrek ve üreter taşlarının vücut dışı şok dalgaları (ESWL) ile tedavisi Maltepe Üniversitesi Hastanesi deneyimi
(Maltepe Üniversitesi, 2011) Sinanoğlu, Orhun; Ekici, Sinan; Tatar, Naci; Turan, Güven; Keleş, Ahmet
Amaç: Vücut dışı şok dalgaları ile taş tedavisi (ESWL) ürolitiyazis tedavisinde kullanılan invazif olmayan bir yöntemdir. Bu çalışmanın amacı ürolitiyaziste kullanılan ESWL tedavisinin sonuçlarını ve uygun endikasyonlarını ortaya koymaktır. Yöntem: Temmuz 2009-Temmuz 2011 arasında üriner sistemde soliter taş nedeniyle ESWL tedavisine alınan 51 hasta çalışmaya alındı. ESWL seanslarını takibeden 3 ay içinde taşsızlık durumu ve komplikasyonlar gözlenip değerlendirildi. Bulgular: Ellibir hastanın 38'i (% 74.5) erkek 13'ü kadındı (% 25.5). Hastaların yaşları 20-73 arası değişmekteydi (ort. 41.7 yıl). Kırkdört hastada (% 86) üç ay sonunda taştan tam arınma gerçekleşti. Otuzüç böbrek ve 18 üreter taşının sırasıyla 29'unda (88 %) ve 13'ünde (72%) arınma sağlandı. ESWL yapılan 7 hastada başarı sağlanamadı, Üreterorenoskopik litotripsi ve perkütan nefrolitotomi gibi invazif girişimler uygulandı. Sonuç: ESWL özellikle ürolitiyazis tedavisinde son derece etkin ve invazif olmayan bir tedavi yöntemidir. Bu çalışmada böbrek ve üreter taşlarında başarı şansı sırasıyla %88 ve %72 bulunmuştur. Ayrıca taş üriner sistemde ne kadar distalde ise başarı şansı o kadar düşmektedir.
Buried penis accompanied by undescended testicles and megameatus hypospadias as a severe genital manifestation of Robinow Syndrome
(SPRINGER WIEN, 2014) Ersoy, Burak; Akoz, Tayfun; Ekici, Sinan
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Can We Predict the Surgical Margin Positivity in Patients Treated with Radical Prostatectomy? A Multicenter Cohort of Turkish Association of Uro-Oncology
(GALENOS YAYINCILIK, 2015) Bolat, Deniz; Eskicorapci, Saadettin; Karabulut, Erdem; Baltaci, Sumer; Yildirim, Asif; Sozen, Sinan; Ates, Ferhat; Sekerci, Cagri Akin; Kurtulus, Fatih; Dirim, Ayhan; Muezzioglu, Talha; Can, Cavit; Bozlu, Murat; Gemalmaz, Hakan; Ekici, Sinan; Ozen, Haluk; Turkeri, Levent
Objective To analyze the parameters that predict the surgical margin positivity after radical prostatectomy for localized prostate cancer. Materials and Methods In this multicenter study, the data of 1607 consecutive patients undergoing radical prostatectomy for localized prostate cancer in 12 different clinics in Turkey between 1993-2011 were assessed. Patients who had neoadjuvant treatment were excluded. We assessed the relationship between potential predictive factors and surgical margin status after radical prostatectomy such as age, cancer characteristics, history of transurethral prostate resection, surgical experience and nerve-sparing technique by using univariate and multivariate Cox regression analyses and t test. Results The overall surgical margin positivity rate was 22.6% (359 patients). In univariate analyses, preoperative prostate specific antigen level, clinical stage, biopsy Gleason score, percentage of tumor involvement per biopsy specimen, transurethral prostate resection history, surgical experience and nerve-sparing technique were significantly associated with positive surgical margin rate. In multivariate analyses, preoperative prostate specific antigen level (OR: 1.03, p=0.06), percentage of tumor involvement per biopsy specimen (OR: 7,14, p<0,001), surgical experience (OR: 2.35, p=0.011) and unilateral nerve-sparing technique (OR: 1.81, p=0.018) were independent predictive factors for surgical margin positivity. Conclusion Preoperative prostate specific antigen level, percentage of tumor involvement per biopsy specimen, surgical experience and nerve-sparing technique are the most important predictive factors of surgical margin positivity in patients undergoing radical prostatectomy for localized prostate cancer.
Clusterin Immunoreactivity as a Predictive Factor for Progression of Non-Muscle-Invasive Bladder Carcinoma
(KARGER, 2011) Ekici, Sinan; Eroglu, Alper; Ekici, A. Isin Dogan; Turkeri, Levent
Introduction: There is a need for prognostic markers which can predict the subset of patients who will not respond sufficiently to conservative management in non-muscle-invasive bladder carcinoma. We analyzed the association of clusterin (CLU) with clinicopathological factors. Materials and Methods: Immunohistochemical CLU expression was investigated in paraffin-embedded archival tissues of initial transurethral resection specimens of 46 patients with non-muscle-invasive bladder carcinoma. The result was expressed as the proportion of the number of CLU-containing tumor cells to the total number of tumor cells detected in each slide and 'percent CLU expression' was calculated for each patient. Results:Of the 46 cases (35 male, 11 female), 18 were >= 65 years of age. CLU expression was significantly higher in male and elderly patients. Following the initial transurethral resection, 39 patients showed tumor recurrence, and progression was seen in 25 patients, of whom 17 progressed to muscle invasion during follow-up. Although there was no significant correlation between CLU expression and recurrence, significant correlation with overall progression and progression to muscle-invasive disease was observed in this cohort of patients (p = 0.001 and p = 0.014, respectively). Among the patients with progression to muscle invasion, 13 underwent radical cystectomy with pT2 tumor in 5 patients in the final pathology of surgical specimens and pT3 and higher in the remainder. Conclusions:CLU immunoreactivity showed correlation with age, gender and progression, mainly progression to muscle invasion. Thus, CLU can be used as a molecular marker to predict the potential of progression to muscle-invasive disease in a particular tumor which in turn may prove useful in the decision-making process for early cystectomy without losing time with conservative management. Copyright (C) 2010 S. Karger AG, Basel
Comparison of conventional radiography combined with ultrasonography versus nonenhanced helical computed tomography in evaluation of patients with renal colic
(SPRINGER, 2012) Ekici, Sinan; Sinanoglu, Orhun
The aim of this study is to determine whether kidneys ureters bladder X-ray (KUB) film combined with ultrasound (US) can be effectively used in evaluation of renal colic and miss stones with clinically significant size identified on nonenhanced computed tomography (NECT) in patients with urolithiasis. This retrospective study evaluated the clinical and radiological records of 300 patients at our institution undergoing KUB and/or US and/or NECT for the evaluation of renal colic from June 2007 to December 2010. Of patients with negative findings on KUB and/or US, 22 had renal stones on NECT (mean size 4.4 mm, range 3-8), 3 had lower ureteral stone (mean size 3.3 mm, range 2-5). In patients with isolated suspicious renal ectasia without stone image, two had renal stone on NECT (mean size 4 mm, range 2-6), 5 had upper ureteral stone (mean size 4.4 mm, range 4-6), 7 had middle ureteral stone (mean size 3.7 mm, range 3-4) and 14 had lower ureteral stone (mean size 4 mm, range 2-6). The cost-effective and almost radiation-free combination of KUB and US should be preferred for diagnosis of urolithiasis, as it detects most of the ureteral and renal calculi which are clinically significant.
COMPARISON OF HOUNSFIELD UNITS OF THE RENAL PAPILLAE IN KIDNEY STONE FORMERS AND NON STONE FORMERS
(NOBEL ILAC, 2014) Sinanoglu, Orhun; Ekici, Sinan; Cakiroglu, Basri; Cubuk, Rahmi; Aksoy, Suleyman Hilmi
Objective: To investigate whether renal papillae of patients with nephrolithiasis are more radiodense than that of control patients and to evaluate the predictibility of urolithiasis events using papillary density differences between stone and non stone formers. Material and Method: Hounsfield unit (HU) values of the papillae of 212 patients with unilateral nephrolithiasis and 108 patients in the control group at the level of the upper pole, middle region and lower pole of both kidneys were evaluated. Results: Mean HU density of all papillae of kidneys with stones was higher than that of stone free kidneys in nephrolithiasis patients (27.21 +/- 2.83 vs 25.66 +/- 2, p=0.000). Mean HU density of renal papillae of stone patients in calyces with stones was significantly higher than that of all papillae in control patients (25,82 +/- 1.97 vs 30,25 +/- 4,03, p<0,001). Mean HU density of all papillae in stone-free kidneys of nephrolithiasis patients was not significantly different from that of control patients (25.82 +/- 1.97 vs 25.66 +/- 2.57, p=0.642). When the values for control and patient groups according to stone laterality was evaluated, the difference was significant only between right upper and right lower calyces for the right nephrolithiasis and the left middle region for the left nephrolithiasis. (26.32 +/- 3.30 vs. 27.90 +/- 3.92 and 25.10 +/- 3.34 vs. 26.95 +/- 4.73, p=0.003 and p=0.009 and 25.70 +/- 3.67 vs 27.15 +/- 3.77 p=0.001, respectively). Conclusion: Only the kidneys with stones and especially the patients with papillae facing the stones in nephrolithiasis have higher renal papillary HU. This fact implies the impossibility of HU per se in predicting future urolithiasis events and/or patients; opposing to the findings of a few previous studies.
Comparison of Intravesical Application of Chondroitin Sulphate and Colchicine in Rat Protamine/Lipopolysaccharide Induced Cystitis Model
(UROL & NEPHROL RES CTR-UNRC, 2014) Sinanoglu, Orhun; Ekici, Isin Dogan; Ekici, Sinan
Purpose: To investigate beneficial effect of the readily available colchicine through its intravesical application on protamine/lipopolysaccharide induced interstitial cystitis model in rat and to compare its efficacy to the chondroitin sulphate available for clinical use. Materials and Methods: Twenty-four Wistar female rats were assigned to control (C), interstitial cystitis (IC), chondroitin sulphate (CS) and colchicine (Col) groups. IC, CS and Col groups received protamine sulphate and lipopolysaccharide (PS/LPS) instillation. Testing agents CS and Col were administered a day after PS/LPS inoculation into the bladders. Rats in Group C received saline solution. CS and Col groups received 1 mL CS (0.2%) and 1 mL Col (0.05 mg/mL). The treatment agents were left in bladders for one hour's duration. Animals were sacrificed 5 days after the inoculation and the bladder tissues were examined histologically to evaluate the amount of extravasated leucocytes, mast cell concentration (by counting total number of cells per 10 high power field (hpf; 1 hpf = x400 magnification) as well as interstitial tissue edema for each bladder. Results: Intravesical application of CS reduced significantly the leucocyte and mast cell infiltration as well as interstitial edema compared to group C. The level of reduction in leucocyte and mast cell infiltration in Col group was comparable to that of CS, although the interstitial edema was not resolved. Conclusion: Intravesical administration of Col decreased leucocyte and mast cell infiltration to the same extent of CS in PS/LPS induced bladder inflammation in rat. Col may be an alternative to other treatment modalities for painful bladder conditions such as IC.
Comparison of Melatonin and Ozone in the Prevention of Reperfusion Injury Following Unilateral Testicular Torsion in Rats
(ELSEVIER SCIENCE INC, 2012) Ekici, Sinan; Ekici, A. Isin Dogan; Ozturk, Guler; Aksungar, Fehime Benli; Sinanoglu, Orhun; Turan, Guven; Luleci, Nurettin
OBJECTIVE To compare the efficacy of ozone with melatonin, shown as the most powerful antioxidant in attenuation of testicular ischemia/reperfusion injury, in an experimental rat model of testicular torsion/detorsion. METHODS Twenty-four male Wistar rats were divided into 4 groups: sham-operated, torsion/detorsion, torsion/detorsion plus melatonin, and torsion/detorsion plus ozone. Melatonin (10 mg/kg) and ozone (4 mg/kg) were intraperitoneally injected daily beginning 15 minutes before detorsion for the following 7 days. At the seventh day, blood and tissue samples were obtained. Johnsen score, malondialdehyde, inhibin B, glutathione plasma total sulfhydryl group (RSH) levels, and total nitric oxide were studied. RESULTS Torsion/detorsion caused increase in tissue malondialdehyde and total nitric oxide along with a decrease in Johnsen score, tissue and plasma inhibin B, RSH, and glutathione levels. Melatonin prevented the rise in malondialdehyde and total nitric oxide levels and improved Johnsen score, tissue and plasma inhibin B, and tissue glutathione levels, along with a decrease in plasma RSH level. Ozone showed similar results except for the total nitric oxide level. Concomitantly, in contralateral testis, melatonin and ozone induced similar changes for Johnsen score, malondialdehyde, and inhibin B (not significant) and in glutathione (significant). Melatonin decreased the total nitric oxide level in both testes and ozone increased the same parameter. CONCLUSION On different pathways, ozone was comparable with melatonin in the amelioration of ischemia/reperfusion injury. Protective effects of ozone were associated with nitrous oxide. The potential for ozone as a treatment for torsion/detorsion therefore deserves to be further elucidated. UROLOGY 80: 899-906, 2012. (C) 2012 Elsevier Inc.
Comparison of plasmakinetic transurethral resection of the prostate with monopolar transurethral resection of the prostate in terms of urethral stricture rates in patients with comorbidities
(Elsevier Inc, 2014) Sinanoğlu, Orhun; Ekici, Sinan; Balci, M. B. Can; Hazar, A. Ismet; Nuhoğlu, Baris
Purpose: To compare urethral stricture rates in comorbid patients undergoing plasmakinetic transurethral resection of the prostate (PK-TURP) and monopolar transurethral resection of the prostate (M-TURP) for benign prostatic hyperplasia. Methods: The data of 317 patients with comorbidities undergoing either PK-TURP or M-TURP from September 2008 to December 2012 were retrospectively evaluated. Preoperative and postoperative 12-month International Prostate Symptom Score, maximal flow rate, postoperative International Index of Erectile Function scores, and urethral stricture rates were evaluated. Results: A total of 154 patients underwent M-TURP and 163 patients underwent PK-TURP. Urethral stricture rates were 6/154 in the M-TURP treatment arm and 17/163 in the PK-TURP treatment arm (P= 0.000). In the presence of hypertension and/or coronary artery disease and/or diabetes mellitus, the risk of urethral stricture complication was significantly higher in the PK-TURP group than in the M-TURP group (P= 0.000). Conclusions: The risk of urethral stricture increases with PK-TURP in elderly patients with a large prostate and concomitant hypertension and/or coronary artery disease and/or diabetes mellitus. Therefore, PK-TURP should be performed cautiously in this group of benign prostatic hyperplasia patients.
Comparison of transurethral incision of the prostate and silodosin in patients having benign prostatic obstruction in terms of retrograde ejaculation
(PAGEPRESS PUBL, 2017) Cakiroglu, Basri; Hazar, Aydin Ismet; Sinanoglu, Orhun; Arda, Ersan; Ekici, Sinan
Background: To compare the functional outcomes and retrograde ejaculation (RE) after transurethral incision of the prostate (TUIP) or silodosin in bladder outlet obstruction (BOO) secondary to a small prostate. Methods: Prospectively collected data from December 2011 through December 2014 of 192 LUTS patients having fertility concerns with prostate volume smaller than 40 ml receiving either TUIP or silodosin treatment were prospectively reviewed. The treatment outcomes were evaluated and compared. Results: TUIP was performed in 96 cases and silodosin 8 mg was prescribed in 96 cases. At 12th months after TUIP or continuous silodosin treatment, the decrease in mean International Prostate Symptom Score (IPSS) and postvoiding residual urine (PVR) and the improvement of mean maximal flow rate (Q(max)) were significant (p = 0.000). The improvement in IPPS and Qmax was significantly higher in TUIP group compared to silodosin group (p = 0.005, p = 0.000) with a lower rate of retrograde ejaculation (RE) in TUIP group. (11/96 vs 33/96) (p = 0.000) Conclusions: Both TUIP and silodosin ensures comparable improvement in PVR, IPSS and Q(max) with a lower rate of RE on the TUIP group in prostates weighing less than 40 grams suggesting that TUIP is a better choice in younger patiens seeking preservation of ejaculation with fertility concerns.
Ectopic Ureterocele: An Infrequent Cause of Retrograde Ejaculation and Its Diagnosis: Case Report
(ORTADOGU AD PRES & PUBL CO, 2011) Ekici, Sinan; Sinanoglu, Orhun; Cubuk, Rahmi
Retrograde ejaculation is an uncommon cause of infertility. It may be congenital, acquired or idiopathic. It can be very rarely a consequence of an ectopic ureterocele. Herein, we present an infertile patient with retrograde ejaculation due to ectopic ureterocele and emphasize the role of magnetic resonance imaging in diagnosis. Only three similar cases have been reported in the literature. The pathogenesis of retrograde ejaculation due to ureterocele remains unclear. It is postulated that dilated ectopic ureter in some way affected the development of the innervation of the bladder neck. Ectopic ureterocele should be kept in mind in the differential diagnosis of patients with retrograde ejaculation.
Fluoroquinolone-resistant acute prostatitis requiring hospitalization after transrectal prostate biopsy: effect of previous fluoroquinolone use as prophylaxis or long-term treatment
(SPRINGER, 2012) Ekici, Sinan; Cengiz, Melahat; Turan, Guven; Alis, Esra Ergun
This study aims to scrutinize the hospitalized patients with the diagnosis of acute prostatitis after transrectal ultrasound-guided biopsy of the prostate (TRUSBP) focusing their history of previous antibiotic use, clinical pictures, microbiologic features, and resistance patterns of the isolates. A retrospective evaluation of the records between 2005 and 2010 revealed 13 patients. All patients received ciprofloxacin 500 mg twice a day starting from the day before TRUSBP for 5 days. Positive 13 urine and 7 blood samples (Escherichia coli in 12 patients, Enterococcus species in one) were evaluated for resistance patterns. All were resistant to fluoroquinolones. Extended spectrum beta-lactamase producing E. coli isolated in 4 patients were treated with carbapenems. Empirical ceftriaxone was shifted to carbapenem (4 patients), vancomycin (1 patient). Empirical carbapenem was maintained in 5 patients. Seven patients with elevated PSA received fluoroquinolones for 4 weeks before TRUSBP on the assumption that they had subclinical infectious prostatitis. Previous exposure to fluoroquinolones did not lead to important differences in respect to the studied parameters. The prompt initiation of effective treatment is essential to decrease morbidity and mortality. Empirical treatment would be a second or third generation cephalosporins, or carbapenems according to clinical severity of patients.
Hydrodynamic cavitation kills prostate cells and ablates benign prostatic hyperplasia tissue
(ROYAL SOC MEDICINE PRESS LTD, 2013) Itah, Zeynep; Oral, Ozlem; Perk, Osman Yavuz; Sesen, Muhsincan; Demir, Ebru; Erbil, Secil; Dogan-Ekici, A. Isin; Ekici, Sinan; Kosar, Ali; Gozuacik, Devrim
Hydrodynamic cavitation is a physical phenomenon characterized by vaporization and bubble formation in liquids under low local pressures, and their implosion following their release to a higher pressure environment. Collapse of the bubbles releases high energy and may cause damage to exposed surfaces. We recently designed a set-up to exploit the destructive nature of hydrodynamic cavitation for biomedical purposes. We have previously shown that hydrodynamic cavitation could kill leukemia cells and erode kidney stones. In this study, we analyzed the effects of cavitation on prostate cells and benign prostatic hyperplasia (BPH) tissue. We showed that hydrodynamic cavitation could kill prostate cells in a pressure- and time-dependent manner. Cavitation did not lead to programmed cell death, i.e. classical apoptosis or autophagy activation. Following the application of cavitation, we observed no prominent DNA damage and cells did not arrest in the cell cycle. Hence, we concluded that cavitation forces directly damaged the cells, leading to their pulverization. Upon application to BPH tissues from patients, cavitation could lead to a significant level of tissue destruction. Therefore similar to ultrasonic cavitation, we propose that hydrodynamic cavitation has the potential to be exploited and developed as an approach for the ablation of aberrant pathological tissues, including BPH.
Identification of microRNAs differentially expressed in prostatic secretions of patients with prostate cancer
(WILEY-BLACKWELL, 2015) Guzel, Esra; Karatas, Omer F.; Semercioz, Atilla; Ekici, Sinan; Aykan, Serdar; Yentur, Serhat; Creighton, Chad J.; Ittmann, Michael; Ozen, Mustafa
Prostate cancer (PCa) is one of the leading causes of cancer deaths in men. Since there are limited treatment options available for the advanced tumors, there is an urgent need for novel diagnostic tools for PCa. Prostate secretion samples (PSS) from 23 PCa and 25 benign prostate hyperplasia (BPH) patients were obtained from Urology Department of Bagcilar Educational and Research Hospital (Istanbul). MicroRNA (miRNA) profiling of eight PSS (four from BPH, four from PCa patients) was performed using microarray. Four of significantly deregulated miRNAs were further confirmed using quantitative reverse-transcription PCR (qRT-PCR). Statistical analysis was performed using Student's t-test. ROC curves were plotted with SPSS-15.0. In this study, we aimed to identify a miRNA expression signature that could be used to distinguish PCa from BPH. MiRNA profiling of four PCa and four BPH patients with microarray revealed that miR-361-3p, miR-133b and miR-221 were significantly downregulated and miR-203 was upregulated in PSS of PCa patients. Further qRT-PCR analysis confirmed the altered expressions of these four miRNAs in PSS of 23 PCa and 25 BPH patients. Four miRNAs, together and individually have much power (AUC; 0.950) than PSA has (AUC; 0.463) to discriminate PCa from BPH patients. We have shown for the first time in the literature the presence of miRNAs in the PSS. We suggest PSS as a powerful non-invasive source for evaluation of prognosis in PCa, since prostate massages can be easily applied during routine examination. Our results showed that certain differentially expressed miRNAs in PSS could be used as diagnostics markers. What's new? The association of microRNAs (miRNAs) with cancer initiation, progression, and metastasis has fueled increasing interest in their potential as diagnostic and therapeutic markers. The current study aimed to identify an miRNA expression signature that could be used to distinguish prostate cancer from benign prostatic hyperplasia by using prostate secretions obtained from patients. MiRNAs were found to be present in the prostate secretion samples, with altered expression detected for four miRNAs in particular. The findings suggest that certain miRNAs may be powerful tools for aiding prostate cancer diagnosis.
Ipsilateral Testicular Catch-Up Growth Rate Following Microsurgical Inguinal Adolescent Varicocelectomy
(HINDAWI PUBLISHING CORPORATION, 2012) Sinanoglu, Orhun; Eyyupoglu, Seyit Erkan; Ekici, Sinan
Objective. To evaluate the ipsilateral catch-up growth rates compared to contralateral testicular growth in adolescents with varicocele undergoing microsurgical inguinal varicocelectomy. Materials and Methods. Between December 2005 and May 2007, 39 adolescent patients with grade 2-3 varicocele admitted to our clinic with complaints of pain and/or testicular asymmetry were operated. Preoperative mean age was 14.5 +/- 1.96 (9 17). Testicular volumes were assessed with ultrasound every 3 months. The available followup was 39 months. Results. In our series, mean testicular preoperative volumes were 9.07 +/- 3.19 mL for the right and 5.90 +/- 1.74 mL for the left. Mean testicular volumes at the end of follow up were 13.97 +/- 3.42 mL for the right and 12.20 +/- 4.05 mL for the left. The testicular catch-up growth approximately begins after the 9th month and significant catch-up occurred in the 12 24 months (P < 0.05). Conclusion. Since testicular volume is the primary method of assessing testicular function in adolescents, testicular size can predict future fertility status significantly 9 months after surgical varicocele correction.
Is it possible to predict BCG effectivity in the treatment of superficial bladder cancer? Are there any markers?
(Galenos Yayincilik, 2012) Turker, P.; Ekici, Sinan
Aim: Bacillus Calmette-Guerin (BCG) is a standard treatment for reducing tumour recurrence and delaying progression of highrisk, non-muscle-invasive bladder tumours. However, it is not clear yet which patients are more likely to be responders to BCG. New Findings: The host factors and the tumor characteristics failed to be an independent factor in the prediction of BCG affectivity in the treatment of non-muscle invasive bladder cancer. The local immune response after intravesical BCG installation was studied meticulously and the predictive value of the elements in this pathway was determined. Among these urine levels of IL-2 has most encouraging results and also the determination of nucleotide polymorphisms of different cytokines in the inflammatory pathway seem promising. Results: Research continues to determine which patients would benefit from BCG treatment and also to establish a better outcome. New approaches are needed in the light of developments in biomedical technology. A very critical part of this therapy is to find out the correlation of different cytokines with BCG therapy, which will give a better insight not only the mechanism but also a better therapeutic options.

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