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    Can complete blood count parameters be a good marker for substance use disorder?
    (Taylor & Francis Inc, 2023) Arat Çelik, Hidayet Ece; Kendirlioğlu, Burcu Kok; Tunç, Ayşe Ece Büyüksandalyacı; Çörekli, Esma; Demir, Sevin; Kucukgoncu, Suat
    ObjectiveInflamatory processes play an important role in the etiology of psychiatric disorders. The aim of this study was to evaluate inflammatory complete blood count (CBC) parameters in substance use disorder (SUD).MethodsThe study included 90 patients with SUD and 90 healthy controls (HC). The Student t-test was used to compare CBC parameters between the groups. The Kruskal - Wallis test was used to compare the data on the basis of substance types.ResultsLeukocyte, lymphocyte, and monocyte levels were higher in SUD group than HC. Leukocyte and neutrophil levels of patients with opioid use disorder (OUD) were higher than HC. Platelet levels and neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and systemic immune inflammation index values were higher in patients with OUD than in patients with non-opioid substance use disorder (nOUD). Moreover, lymphocyte and monocyte levels were higher in patients with nOUD than in HC. Monocyte levels were increased in patients with cannabinoid use disorder compared to HC.ConclusionThe results suggested that inflammatory CBC parameters play an important role in the etiology of SUD according to type of substance. However, there is not enough data for supporting the clinical use of these parameters..
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    New Anthropometric Measurements: Relationship to Thyroid Functions in Euthyroid Obese Subjects
    (Cureus Inc, 2021) Demir, Sevin; Kara, Yasin; Melikoğlu, Merve; Aydın, Kadriye; Özderya, Ayşenur; Subasi, Huriye Ecem; Dabak, Mustafa Resat
    Introduction Body mass index (BMI) is unable to make a distinction between muscle mass and fat mass. Therefore, new anthropometric measurements, such as a body shape index (ABSI), body round index (BRI), and body adiposity index (BAI), have been formulated in recent years. Many studies have reported a correlation between BMI and thyroid function. In this study, we aimed to investigate the relationship between the above-mentioned new anthropometric measurements and thyroid functions in euthyroid obese subjects. Methods We included 675 euthyroid (TSH >= 0.4 and < 4.5 mIU/1) individuals from the obesity outpatient clinic, aged between 18 and 65 years old, with BMI >= 30. Thyroid-stimulating hormone (TSH), free T4 (fT4) and free T3 (fT3), anthropometric measurements (weight, height, and waist circumference), and bioelectric impedance analyses [percent body fat (PBF) and fat-free mass (FFM)J of individuals were measured and recorded. ABSI, BRI, and BAI were calculated with the data from these measurements. Anthropometric measurements were compared to thyroid function tests. Results Eighty percent of the subjects were female. The mean age and BMI were 38 +/- 17 years and 38 +/- 6 kg/m(2), respectively. TSH was found to be negatively correlated with ABSI (p = 0.006) and positively correlated with BAI (p < 0.001), but a statistically significant relationship with BRI (p = 0.193) was not determined. Free T4 was not associated with any of the anthropometric measurements. While fT3 was determined to be positively correlated with ABSI (p= 0.008) and negatively correlated with PBF and BAI (p= 0.001, p= 0.002, respectively), no statistically significant relationship with fF3 and BRI was determined. Conclusion TSH is positively correlated with measurements of adiposity such as BMI, PBF, BAI while indexes in which abdominal obesity increases, such as waist circumference (WC), waist-hip ratio (WHR), and ABSI, are correlated with fT3 levels.