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Yayın The association of endoplasmic reticulum aminopeptidase-1 (ERAP-1) with Familial Mediterranean Fever (FMF)(SAGE PUBLICATIONS INC, 2016) Sezgin, Gulbuz; Dabak, Resat; Kaya, Fatih Oner; Kotevoglu, Nurdan; Uygur-Bayramicli, Oya; Nalbant, SelimBackground: The ERAP1 gene cleaves the receptors and reduces their ability to transmit chemical signals to the cell that affect the process of inflammation and, secondly, it cleaves many types of proteins into small peptides that are recognized by the immune system. Objective: ERAP-1 gene mutations may create a sensitivity for Familial Mediterranean Fever (FMF). Method: We included 15 FMF patients with the M694 (+) mutation in the study in order to exclude patients without pyrin gene mutations and create a homogeneous study group. Fifteen patients with ulcerative colitis formed the control group. Results: There wasn't any case without ERAP-1 gene mutations. At least one mutation at exon 3 or exon 10 was found in all cases in both groups. There were 14 ERAP-1 gene mutations at exon 10 and 11 at exon 3 in patients with FMF. Interestingly, if there were ERAP-1 gene mutations at exon 3, a p.Arg127 Pro (c.380G>C) mutation always existed for three FMF patients with polymorphic mutations at this exon. There were 11 ERAP-1 gene mutations at exon 10 and 12 gene mutations at exon 3 in patients with ulcerative colitis. Exon 3 mutations were usually single p.Arg127 Pro (c.380G>C) mutations for 12 patients with ulcerative colitis as seen in the patients with FMF. The single mutation was always p.Ser453 Ser (c.1359T>C) for patients with ulcerative colitis at exon 10. Conclusion: There are more ERAP-1 mutations in the FMF group in comparison to the ulcerative colitis group. So, there may be a strong susceptibility to ERAP-1 gene mutations in FMF patients according to our results. However, further studies with larger study and control groups are needed.Yayın Asymptomatic Brain Lesions on Cranial Magnetic Resonance Imaging in Inflammatory Bowel Disease(EDITORIAL OFFICE GUT & LIVER, 2013) Dolapcioglu, Can; Guleryuzlu, Yuksel; Uygur-Bayramicli, Oya; Ahishali, Emel; Dabak, ResatBackground/Aims: This study aimed to examine the frequency and type of asymptomatic neurological involvement in inflammatory bowel disease (IBD) using cranial magnetic resonance imaging (MRI). Methods: Fifty-one IBD patients with no known neurological diseases or symptoms and 30 controls with unspecified headaches without neurological origins were included. Patients and controls underwent cranial MRI assessments for white matter lesions, sinusitis, otitismastoiditis, and other brain parenchymal findings. Results: The frequencies of white matter lesions, other brainstem parenchymal lesions, and otitis-mastoiditis were similar in IBD patients and controls (p>0.05), whereas sinusitis was significantly more frequent in IBD patients (56.9% vs 33.3%, p=0.041). However, among those subjects with white matter lesions, the number of such lesions was significantly higher in IBD patients compared to controls (12.75 +/- 9.78 vs 3.20 +/- 2.90, p<0.05). The incidence of examined pathologies did not differ significantly with disease activity (p>0.05 for all). Conclusions: The incidence of white matter lesions seemed to be similar in IBD patients and normal healthy individuals, and the lesions detected did not pose any clinical significance. However, long-term clinical follow-up of the lesions is warranted. (Gut Liver 2013;7:169-174)Yayın Investigation of human papillomavirus DNA in colorectal carcinomas and adenomas(HUMANA PRESS INC, 2011) Yavuzer, Dilek; Karadayi, Nimet; Salepci, Taflan; Baloglu, Huseyin; Dabak, Resat; Bayramicli, Oya UygurHuman papillomavirus (HPV) has been considered to be an etiological agent for anogenital cancers, such as cervical cancer and possibly a subset of cancers of the aerodigestive tract. The aim of the study was to evaluate the presence of human papillomavirus DNA in colorectal carcinomas and adenomas. Formalin-fixed and paraffin-embedded archival tissue samples were used for DNA extraction. One hundred and six colorectal carcinomas and 62 adenomas were screened by nested polymerase chain reaction (PCR) for HPV DNA with a control group of 49 cervical tissues with invasive cervical carcinoma and cervical intraepithelial neoplasia (CIN). In the study group, we did not find HPV DNA positivity in any of all the colorectal carcinomas and adenomas. In the control group with cervical lesions, 34 out of 49 (69.4%) samples were positive for the HPV DNA. These results indicated that there was no correlation between HPV infection and colorectal carcinomas and adenomas.Yayın Multipl sklerozda barsak hareket bozuklukları ve amiloidoz ile ilişkisi(2012) Alp, Recep; Yavuzer, Dilek; Dabak, Resat; Bayramiçli, Oya Uygur; Duman, Arda; Börü, Ülkü TürkAmaç: Bağırsak hareket bozuklukları, multipl sklerozlu (MS) hastalarda sık görülmektedir. Bu çalışmanın amacı, kolon geçiş zamanını araştırmak ve bununla birlikte bağırsak motilite bozukluklarının sıklığı, lezyonların yeri ile ilişkisi ve yineleyici multipl skleroz (RR-MS) hastalarında tekrarlayan amiloidoz varlığı ile ilişkisini irdelemektir. Yöntem: Bu çalışmaya klinik kesin yineleyici MS (RR-MS)’i bulunan 18 hasta dahil edildi. Bağırsak motilite bozuklukları ROMAII kriterlerine göre sınıflandırıldı ve tüm hastalara kolonoskopi yapıldı. Kolonoskopik biyopsi örnekleri amiloidoz varlığı açısından değerlendirildi. Colontransit 20 pelet ile kolon geçiş süreleri hesaplandı. Bulgular: Hastaların yaş ortalaması 34,3 yıl idi. Hastaların 12’si kadın ve 6’sı erkekti. Ortalama MS süresi 7,6 yıl ve genişletilmiş özürlülük durumu skoru (EDSS) ortalama 2,0 olarak bulundu. Hastaların 12’sinde kabızlık ve 3’ünde ishal bulundu. Hastalarda bağırsak motilite bozuklukları (kabızlık ve ishal) nükslerden 2±1 gün önce ortaya çıkmakta ve nüksler sırasında da devam etmekte idi. İstatistiksel olarak, bağırsak işlev bozukluğu ile atak sayısı arasında (p = 0,021) korelasyon saptandı. Kolon geçiş süresi ile atak sayısı ve MS süresi (sırasıyla p = 0,013, p = 0,006) arasında istatistiksel olarak anlamlı bir ilişki vardı ve buna ek olarak hiçbir hastanın biyopsisinde amiloidoz saptanmadı. Sonuç: Bu çalışmada, uzun süreli kolon geçiş zamanı ve yineleyici MS hastalarında bağırsak işlev bozukluğu(özellikle kabızlık) varlığını göstermektedir. Patofizyolojisi ise henüz tam bilinmemektedir.Yayın Peptik ülser ve gastrit saptanan hastalarda helicobacter pylori sıklığı(2013) Dolapçıoğlu, Can; Dabak, Resat; Emre, Emre; Emre Sümer, Şahika; Bayramiçli Uygur, Oya; Ahıshalı, Emel; Keser Hallaç, SevinçAmaç:Son yıllarda yapılan çalışmalarda Helicobacter pylori(H. pylori) negatif peptik ülser oranlarında artış olduğu bildirilmektedir. Bölgemizdeki peptik ülser ve gastritli hastalardaki H. pylorisıklığını araştırdık. Gereç ve Yöntem:Çalışmamızda 2008 Temmuz-2010 Aralık tarihleri arasında üst gastrointestinal sistem (GİS) endosko pisi yapılan 2500 hastanın gastroskopi raporları geriye dö nük olarak değerlendirildi; 2052 hasta çalışmaya alındı. Pa toloji raporları incelenerek H. pylori ve intestinal metaplazi pozitifliği değerlendirildi. Bulgular:Hastaların yaş ortalaması 44.76±14.20 yıldı, 1137’si (%55.4) kadındı.H. pylori 919 (%44.8) hastada pozitif bulundu. Mide ülserinde H. pylori pozitifliği %54.5, duodenal ülserde %67.3, gastrik ve duodenal ülserde %63, gastritde ise %40.8 bulundu. Hastaların 275’inde (%13.4) intestinal metaplazi saptandı. Kadın ve erkek hastalar arasında H. pylori sıklığı açısından anlamlı fark bulunmadı. H. pylori pozitifliği ile intestinal metaplazi arasında istatistiksel olarak anlamlı ilişki bulunmadı. Yaşı 50’nin altında olan hastalarda H. pylori pozitifliği ?50 yaş olan hastalara göre anlamlı yüksek bulundu (p=0.000). Sonuç:Çalışmamızda peptik ülser ve gastritte H. pyloripozitifliğinin önceki yıllara göre azaldığı bulunmuştur.Yayın The relationship between serum adiponectin and resistin levels, insulin resistance and colorectal adenomas(AVES, 2015) Demir, Nazli; Ahishali, Emel; Dolapcioglu, Can; Ercan, Serif; Kaptanagasi, Asuman Orcun; Dabak, Resat; Yucel, Nihal; Sargin, Mehmet; Bayramicli, Oya UygurBackground/Aims: The relationship between adipocytokines and the development of colorectal cancer is well-documented. Our aim was to assess the relationship among serum adiponectin and resistin levels, insulin resistance, and colorectal adenoma to evaluate whether these parameters can be used as biomarkers to predict the development of colorectal adenoma. Materials and Methods: This is a cross-sectional case-control study conducted in 32 patients with colorectal adenoma and 30 control subjects. Serum adiponectin and resistin levels, body mass index values, waist and hip circumferences and Homeostasis Model Assessment scores were measured. Results: Resistin levels were slightly higher and adiponectin was slightly lower in patients with colorectal adenoma compared with controls; however, the differences in both parameters failed to reach statistical significance. The body mass index values and waist circumference of the patient group were significantly higher than controls (p=0.003 and p=0.002, respectively). Fasting serum insulin levels and Homeostasis Model Assessment scores of patients with colorectal adenoma were significantly higher than those of controls (p=0.02 and p=0.02, respectively). There was no relation between the number of colorectal adenomas and serum adiponectin or resistin levels. Conclusion: Our data indicate that obesity and insulin resistance may contribute to the development of colorectal adenoma and that serum adiponectin levels and insulin resistance may not have a substantial predictive value for colorectal adenoma.Yayın Risk of endocrine pancreatic insufficiency in patients receiving adjuvant chemoradiation for resected gastric cancer(ELSEVIER IRELAND LTD, 2013) Gemici, Cengiz; Sargin, Mehmet; Uygur-Bayramicli, Oya; Mayadagli, Alpaslan; Yaprak, Gokhan; Dabak, Resat; Kocak, MihribanBackground: Adjuvant radiotherapy combined with 5-fluorouracil based chemotherapy has become the new standard after curative resection in high risk gastric cancer. Beside many complications due to surgery, the addition of chemotherapy and radiotherapy as adjuvant treatment may lead to both acute and late toxicities. Pancreatic tissue irradiation during this adjuvant treatment because of incidental and unavoidable inclusion of the organ within the radiation field may affect exocrine and endocrine functions of the organ. Materials and methods: Fifty-three patients with gastric adenocarcinoma were evaluated for adjuvant chemoradiotherapy after surgery. While 37 out of 53 patients were treated postoperatively due to either serosal or adjacent organ or lymph node involvement, 16 patients without these risk factors were followed up regularly without any additional treatment and they served as the control group. Fasting blood glucose (FBG), hemoglobin A1c (HBA1c), insulin and C-peptide levels were measured in the control and study groups after the surgery and 6 months and 1 year later. Results: At the baseline there was no difference in FBG, HbA1c, C-peptide and insulin levels between the control and the study groups. At the end of the study there was a statistically significant decline in insulin and C-peptide levels in the study group, (7.5 +/- 6.0 vs 4.5 +/- 4.4 IU/L, p: 0.002 and 2.3 +/- 0.9 vs 1.56 +/- 0.9 ng/ml, p: 0.001) respectively. Conclusions: Adjuvant radiotherapy in gastric cancer leads to a decrease in beta cell function and insulin secretion capacity of the pancreas with possible diabetes risk. Radiation-induced pancreatic injury and late effects of radiation on normal pancreatic tissue are unknown, but pancreas is more sensitive to radiation than known. This organ should be studied extensively in order to determine the tolerance doses and it should be contoured during abdominal radiotherapy planning as an organ at risk. (C) 2013 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 107 (2013) 195-199
