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Yayın A case with ataxia, optic neuropathy and polyneuropathy: is there any association with imatinib or natural course of chronic myeloid leukemia?(Maltepe Tıp Dergisi, 2018) Özünal, Zeynep Güneş; Cam, Özlem; Şahin, Şevki; Sağlam, Esra; Karşıdağ, SibelImatinib is a tyrosine kinase inhibitor as a antineoplastic agent which is indicated in chronic myeloid leukemia (CML), various hematologic and nonhematologic malignancies. Forty-seven years old male, with CML diagnosis 15 years ago and had stem cell transplantation 2 years ago and receiving radiotherapy and chemotherapy. After then, imatinib 400 mg daily is prescribed on for 12 months by the physician but patient himself continued for 15 months until he suspected drug when he has newly onset walking, swallowing difficulties and blurry vision. Imatinib and possible adverse drug reactions are discussed in the case presentation.Yayın A comparison of NCT, Goldman application tonometry values with and without fluorescein(National Library of Medicine, 2018) Erdoğan, Hakika; Akıngöl, Ziya; Cam, Özlem; Şencan, SadıkPurpose The aim of the study was to statistically compare intraocular pressure (IOP) values measured using noncontact tonometer (NCT), Goldmann applanation tonometry (GAT) with fluorescein (fGAT), and GAT without fluorescein (nGAT). The study was also performed to test whether the values obtained using each technique change in accordance with the central corneal thickness (CCT) and refractive and keratometric values. Study design This study was a prospective study of 188 eyes of 94 healthy volunteers. Methods: IOP was measured using fGAT, nGAT and NCT. CCT, refractive values, and keratometric values were measured, and the correlations and differences in the IOP for each tonometer were investigated. Results The mean IOP values obtained with the NCT, nGAT, and fGAT were 17.5±3.7, 12.3±2.7, and 12.5±2 mmHg. The mean CCT was 538.2±34.4 µm, the mean refractive value was 0.9±1.2 D, and the mean keratometric value was 43.5±1.5 D. NCT was positively correlated with fGAT and GAT values and was significantly higher than both the values. There were no differences between fGAT and GAT values. No correlation was observed between the CCT and keratometric and refractive values and the difference between NCT and nGAT or fGAT. Conclusion Differences in the measurements obtained using nGAT and fGAT were insignificant (P>0.05). Both values were positively correlated with NCT measurements (r =0.354, P<0.05) and were independent of CCT, keratometry, and refraction values. nGAT appears to be suitable for use in routine clinic practice.Yayın Efficacy of interleukin-1 targeting treatments in patients with familial mediterranean fever(Springerlink, 2014) Çetin, Pınar; Sarı, İsmail; Sözeri, Betül; Cam, Özlem; Birlik, Merih; Akkoç, Nurullah; Önen, Fatoş; Akar, Servet—Herein, we reported our experience in colchicine-resistant familial Mediterranean fever (FMF) patients who are treated with anti-interleukin-1 (IL-1) drugs. A retrospective review of medical records of anti-IL-1 recipients was performed. The main clinical characteristics of these patients and the evolution after anti-IL-1 were recorded. There were 20 patients (11 male [M] and 9 female [F]). Despite regular colchicine treatment, median number of attacks per month and per year was 1 (1–4) and 12 (4– 50), respectively. Twelve patients were receiving anakinra, and eight patients were treated with canakinumab. The number of monthly and yearly attacks after IL-1 treatment was significantly decreased after the biologic agent (p<0.05). One patient did not respond to the treatment, and one patient developed serious infection during anti-IL-1. We also observed a significant decrease in proteinuria in the amyloidosis complicated FMF patients. Anti-IL-1 targeting drugs seem safe and effective therapies in colchicine-resistant FMF.Yayın Optical coherence tomography of bilateral nanophthalmos with macular folds and high hyperopia(Turkish Ophthalmology Society, 2014) Helvacıoğlu, Fırat; Kapran, Ziya; Şencan, Sadık; Uyar, Murat; Cam, Özlemmportance. There is a conflict about the content of the macular folds in nanophthalmic eyes in the literature. Our study clearly demonstrated that papillomacular folds seen in nanophthalmos or posterior microphthalmos were only composed of neurosensory retina without involvement of retinal pigment epithelium and choroid. Observations. This is a report of two consecutive nanophthalmic patients with macular folds at Maltepe University School of Medicine, Department of Ophthalmology, from January to June 2012. Anterior segment dimensions were near normal. The axial lengths of the eyes were short with markedly shortened posterior segment. A macular fold extending from the center of the fovea towards the optic nerve head was present in all eyes. Optic coherence tomography clearly demonstrated that folds were only composed of neurosensory retina. Binocular visual acuities and refractive errors of the cases were 0.3, 0.2 and +16.00, +15.75 diopters, respectively. Conclusions and Relevance. Our study proposes a surgical option to treat these folds like serous retinal detachments by showing the true content of the folds, although there is not any surgical operation accepted for this condition yet. Further studies dealing with the surgical interventions of these folds should be performed to support this option.Yayın Surgical approach in myopic maculopathy(Gazi Göz Vakfı, 2015) Kapran, Ziya; Altan, Tuğrul; Cam, ÖzlemSurgical Approach in Myopic Maculopathy