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Yayın Determinants of hospital mortality after repeat mitral valve surgery for rheumatic mitral valve disease(Elsevier, 2006) Albeyoğlu, Şebnem; Sargın, Murat; Çakmak, Mahmut; Göksel, Onur; Bayserke, Olgar; Çınar, B.; Eren, Ergin EminObjective: The aim of this study is to detect the risk factors for hospital mortality in patients who underwent reoperative mitral valve replacement. Methods: Rheumatic mitral valve patients who underwent primary mitral valve replacement (386 cases) and repeat mitral valve replacement (94 cases) were analysed retrospectively. The incremental effects of the reoperative procedure on hospital mortality were studied by comparing primary and reoperative procedures and analyzing a series of possible predisposing factors. Results: Operative mortality for repeat procedures was found significantly higher than the first operations (respectively 12.8% versus 4.3%, p=0.022). Risc factors affecting the hospital mortality in reoperation group were determined as advanced age, diameter of left atrium, prolonged bypass time and development of postoperative low output state. The indication for surgery also had a significant role in patients' outcome. Mortality found significantly higher in cases operated due to endocarditis or mitral mechanical valve thrombosis compared to other reoperation groups. Conclusion: Patients over age of 70 years, with a left atrial diameter over 60 mm, reoperated due to endocarditis and mechanical valve thrombosis, should be reevaluated for risk assessment while giving the decision of optimal operation timing. Especially patients with left ventricular hypertrophy and decreased myocardial reservoirs, efficient myocardial protection during the operation had an important role.Yayın Effect of Low-Dose Dopamine on Renal Function and Electrolyte Extraction During Cardiopulmonary Bypass(TURK NEFROLOJI DIYALIZ TRANSPLANTASYON DERGISI, 2015) Akgun, Sunay; Alicikus Tuncel, Zeliha; Kudsioglu, Sefika Turkan; Coskun, Filiz Izgi; Ukil, Fatma; Karabulut, Sezer; Bayserke, Olgar; Yapici, Nihan; Aykac, ZuhalOBJECTIVE: Kidney damage after cardiac surgery can cause acute renal failure, increase the morbidity and mortality, and prolong the hospital stay. Various methods have therefore been used to prevent renal failure. One of the most frequently used drugs for this purpose is low-dose dopamine (2-4 mcg/kg/min) but it has various disadvantages in addition to advantages. One disadvantage is the increased urinary excretion of electrolytes. We studied the use low-dose dopamine on renal function in patients who had undergone coronary artery bypass surgery. MATERIAL and METHODS : We included 40 patients who were planned to undergo open heart surgery, had developed kidney damage for any reason before the surgery, and had normal ejection fraction (EF) in the study. The data were recorded before and 1, 24, and 48 hours after the operation. RESULTS : When we compared the postoperative 24th hour data, urinary K and Cl were higher in the control group than the dopamine group (p<0.05). Postoperative 24th hour creatinine clearance was higher in the dopamine group than the control group (p<0.05). CONCLUSION: We conclude that the use of low-dose dopamine in cardiopulmonary bypass patients in the postoperative period does not have a positive effect on the renal function and does not affect urinary electrolyte excretion.Yayın Extracranial carotid artery aneurysm due to Behcet's disease(Sage Journals, 2010) Albeyoğlu, Şebnem; Çınar, Bayer; Eren, Tunç; Bayserke, Olgar; Aslan, CenkBehçet's disease is a chronic systemic inflammatory disorder associated with recurrent oral and genital ulcers and iritis. Vascular lesions are encountered in 7%-29% of patients, gravely affecting the course of the disease. Extracranial carotid aneurysms due to Behçet's disease are extremely rare. We describe a surgically treated case of Behçet's disease in a 28-year-old man who presented with a rapidly enlarging left common carotid artery aneurysm.Yayın Kardiyopulmoner baypas uygulanan hastalarda düşük doz dopaminin böbrek fonksiyonları ve elektrolit atılımı üzerine etkisi(2015) Ukil, Fatma; Aykaç, Zuhal; Karabulut, Sezer; Yapıcı, Nihan; Bayserke, Olgar; Tuncel Alıcıkuş, Zeliha; Akgün, Sunaya Maç: Kardiyak cerrahi sonrası gelişen böbrek hasarı (BH), akut böbrek yetmezliği (ABY)gelişimine, mortalite morbidite artışına ve uzamış hastane yatışına neden olmaktadır. Bu sebepleböbrek yetmezliğini engellemek amacıyla çeşitli tedavi yöntemleri kullanılmaktadır. Bunlardan en sıkkullanılanlardan biri de böbrek dozu (2-4mcg/kg/dk) dopamin uygulamasıdır. Fakat bu uygulamanınyararları olduğu gibi zararları da vardır. Bunlardan biri de idrarla elektrolit atılımını artırmasıdır. Bizçalışmamızda koroner baypas cerrahisi yapılan hastalarda düşük doz dopamin kullanımının renalfonksiyonlar üzerinde etkisini araştırdık.Gereç ve yÖ nteMler: Açık kalp cerrahisi planlanan, operasyon öncesi herhangi bir sebepleböbrek hasarı gelişmiş ejeksiyon fraksiyonları (EF) normal olan 40 hasta çalışmaya kabul edildi. Buhastaların operasyon öncesi, operasyon sonrası 1. 24. ve 48. saat verileri kaydedildi.bulGulAr : Her iki grubun postoperatif 24. saat verileri karşılaştırıldığında; kontrol grubunda idrarK ve idrar Cl değerleri dopamin grubuna göre daha yüksek idi (p<0,05). Postoperatif 24. saatte kreatininklirensi dopamin grubunda kontrol grubuna göre daha yüksek bulundu (p<0,05).sO nuç : Kardiyopulmoner baypas uygulanan hastalarda düşük doz dopamin kullanımının postoperatifdönemde böbrek fonksiyonları üzerine olumlu bir etkisinin olmadığı ve idrar elektrolit atılımınıdeğiştirmediği düşünmekteyiz.Yayın Kolesterol ester proteini ve reoperatif koroner arter cerrahisi(Turkish Society of Cardiology, 2006) Göksel, Onur; Çınar, Bayer; Şahin, Veysel; Kut, Sinan; Çetemen, Şebnem; Bayserke, Olgar; Eren, Ergin EminKoroner arter bypass cerrahisi sonrası greftleri tıkanmış olan hastalarda, kolesterol ester transfer proteininin (KETP) aktivitesi değerlendirildi. Çalışma planı: Haziran 2003 Kasım 2004 tarihleri arasında koroner arter bypass tekrar cerrahisi geçiren 20 hasta (grup 1) ile kontrol grupları (primer koroner bypass cerrahisi geçiren 20 hasta [grup 2] ve iskemik nedenlere bağlı olmayan kalp kapak ameliyatı geçiren 20 hasta [grup 3]) KETP aktivitesi, hastaların özellikleri ve hastane mortalite/ morbiditesi açısından karşılaştırıldı. İstatistiksel inceleme açısından grup 2 ve 3 bazı değerlendirmelerde progresif aterosklerozu gösterdiği öngörülen "grup B" olarak adlandırıldı. Bulgular: En yüksek KETP aktivitesi grup 1'de bulundu (sırasıyla 14.28±3.87; 5.42±3.59; 7.08±3.87- grup 1'le karşılaştırıldığında p<0.05). Grup 1 hastalarının yarısında daha önce üç greft kullanıldığı belirlendi (2.85±0.99 greft/hasta). Kaybedilen tek hasta ve belirlenen üç peroperatif miyokard infarktüsü olgusundan ikisi grup 1'de idi. Kolesterol ester transfer proteinin aktivitesi açısından 9.34 değeri progresif aterosklerozun başladığı sınır olarak belirlendi. Kullanılan ROC (receiver operating characteristic curve) analizinde eğri altında kalan alan 0.085- çok iyi olarak bulundu. Sonuç: Genç hastalarda KETP aktivitesinin taranması, bu hastaların orta ve uzun dönem prognozu hakkında bilgi verebilir ve özellikle KETP aktivitesi sınırın üzerindeki hastalarda "aterorezistan" (örn. arteryel) greftlerin tercihi önem kazanmaktadır.Yayın Koroner Arter Bypass Greft Hastalarında Pulmoner Fonksiyonlar ve Nötrofil Lenfosit Oranı Arasında Korelasyon Var mı?(2017) Bayserke, Olgar; Tulgar, Serkan; Özer, Zeliha; Selvi, OnurGİRİŞ ve AMAÇ: Pulmoner Fonksiyon Testleri (PFT) kardiyotorasik cerrahi öncesi preoperatif değerlendirmede sık başvurulan önemli bir testtir. Nötrofil lenfosit oranı ise birçok çalışmaya konu olmuş, bir çok hastalık ile ilişkisi olduğu ortaya konmuş bir biyomarkerdır. Benzer şekilde platellet lenfosit oranı (PLR) ve sistemik immun inflamatuar indexte çalışmalara konu olmaktadır. Bu çalışmada amacımız; CABG hastalarında yapılan PFT ile bu oranlar arasında bir ilişki olup olmadığını araştırmaktır. YÖNTEM ve GEREÇLER: Bu retrospektif çalışmada Ocak 2014 ile Austos 2015 tarihleri arasında merkezimizde CABG uygulanan hastaların verilerini değerlendirilmiştir. CABG uygulanan hastaların demografik özellikler, kan sayımları, NLR, PLR, SIII ve PFT sonuçları kayıt altına alınarak değerlendirilmiştir. BULGULAR: CABG uygulanan 61 hastanın verileri değerlendirildi. NLRile FEV1/FVC ve NLR ile MMEF75-25 arasında negatif yöne bir korelasyon tespit edildi (p<0.01).NLR için MMEF 75-25 < %80 ve FEV1/FVC<%80 olduğunda cut-off değeri belirlemek için ROC analizi yapıldı ve cut off değeri 2.105 olarak belirlendi (Sensitivity %67 ve specificity % 73) TARTIŞMA ve SONUÇ: Respiratuar hastalık öyküsü olmayan ve CABG uygulanacak hastalarda NLR pılmoner fonksiyon testleri ine ters yönlü bir korelasyon göstermektedir. Çalışmamız, tam kan sayımından türetilen basit bir biyomarker olan NLR ile pulmoner fonksiyon testleri ilişkisini ortaya koyan ilk çalışmadır.Yayın Mortality predictors in ST-elevated myocardial infarction patients undergoing coronary artery bypass grafting(Sage Journals, 2011) Kurç, Erol; Çetemen, Şebnem; Soylu, Özer; Aydoğan, Hakkı; Bayserke, Olgar; Yılmaz, Mürüvvet; Uyarel, Hüseyin; Ergelen, Mehmet; Orhan, Gökçen; Uğurlucan, Murat; Eren, Emin Ergen; Yekeler, İbrahimThe use of coronary artery bypass grafting (CABG) in primary treatment of acute myocardial infarction is still debated. We evaluated the predictors of mortality in patients undergoing primary CABG for ST-elevated myocardial infarction (STEMI). Between January 2003 and January 2008, all patients referred to our institution with STEMI who did not qualify for primary angioplasty and required CABG were included in this study. Survivors and nonsurvivors were compared retrospectively in terms of demo-graphics, preoperative, intraoperative, and postoperative characteristics. Preoperatively confirmed cases of STEMI (n = 150) were included in the analysis. There were 114 survivors and 36 nonsurvivors. In-hospital mortality rate was 22%. In Cox regression analysis age, cardiogenic shock (Killip ?3), preoperative cardiac troponin levels, preoperative use of intra-aortic balloon counterpulsation (IABP), previous myocardial infarction, and percutaneous coronary intervention were independent predictors of in-hospital mortality. After multivariate analysis, factors predicting in-hospital mortality were age, preoperative cardiac troponin levels, and preoperative IABP. Age, preoperative cardiac troponin levels, and preoperative IABP use were predictive factors of in-hospital mortality in patients undergoing primary CABG for STEMI.Yayın The relation between blood and tissue magnesium levels and development of atrial fibrillation after coronary artery bypass surgery(Turkish Society of Cardiology, 2010) Şahin, Veysel; Kaplan, Mehmet; Bilsel, Serpil; Çetemen, Şebnem; Bayserke, Olgar; Bilgiç Alkaya, Dilek; Eren, Ergin EminObjective: Atrial fibrillation (AF) is a common complication of cardiovascular surgery and its mechanisms are not well understood. The aim of our study was a prospective investigation of the relationship between AF development and tissue or blood magnesium levels. Methods: This prospective observational study evaluated 20 patients undergoing elective initial coronary artery bypass graft (CABG) surgery. Right atrial appendage and skeletal muscle samples were obtained for tissue magnesium level analysis before, during (at 60th minute) and 30 minutes after cardiopulmonary bypass (CPB) with simultaneous blood samples. Daily measurements of blood Mg levels and continuous monitoring for AF were performed for 7 postoperative days. Statistical analyses were performed using ANOVA, independent samples t and Chi-square tests. Results: AF developed in 5 out of 20 patients during postoperative period (25%). Patients with or without AF did not differ in terms of tissue and blood magnesium levels during and early after CPB and during 7 days after the operation. Blood magnesium levels were significantly higher in the whole study population on postoperative days 3 through 7 (day 3 - 1.13±0.11 mmol/L; day 4-, 1.18±0.07 mmol/L; day 5-1.15±0.10 mmol/L; day 6-1.17±0.08 mmol/L; and day 7, 1.22±0.08 mmol/L) compared to day 1 and day 2 (day 1-0.96±0.13 mmol/L and day 2-1.02±0.12 mmol/L; p=0.002 for all comparisons). Conclusion: Although patients with and without AF did not significantly differ with regard to blood and tissue magnesium levels, the coincidence of an early postoperative reduction in magnesium levels in all patients and occurrence of all AF incidences at this time period suggests a potential association deserving further investigation.Yayın Use of Femoral and Sciatic Nerve Block Combination in Severe Emphysematous Lung Disease for Femoral Popliteal Arterial Bypass Surgery(CUREUS INC, 2018) Selvi, Onur; Bayserke, Olgar; Tulgar, SerkanRegional anesthesia is a widely used anesthesia technique for high-risk patients with severe vascular or pulmonary diseases in which general anesthesia is considered harmful and should be avoided. In this case, we present the use of femoral-sciatic nerve block combination for a 65 year-old, ASA IV, male patient who had severe emphysematous lung disease and was planned for a right femoral-popliteal arterial bypass surgery. He had severe pulmonary disease, hypertension, peripheral vascular disease, and was on clopidogrel treatment. Due to his existing comorbidities, regional anesthesia was considered the right method. The combination of femoral and sciatic nerve block was successfully used for the operation, which lasted for one hour and fifty minutes under sedation, and was continuously supplied with a propofol infusion. The patient was safely discharged to the surgical ward with no pain. The femoral block and sciatic block combination is described as one of the most useful, and at the same time, the most ignored anesthetic method. This technique is considered a standard technique and is often taught early in training; however, its use seems to be underestimated as there are only a few cases documented in Turkey. The aim of this case is to serve as a reminder of its significant value in patients who are not appropriate for general anesthesia and neuraxial blocks.Yayın The variety of non-smoking related cancers in diabetic patients with history of revascularisation interventions due to severe atherosclerotic occlusive diseases(Maltepe Üniversitesi, 2014) Onar, Lütfi Çağatay; Sarıgül, Nedim Umutay; Bayserke, Olgar; Karaca, Ersoy; Haberal, İsmail; Filizcan, UğurBoth diabetes and cancer are prevalent diseases whose incidence is increasing globally. Besides this, new studies showed that number of atherosclerotic arterial acclusive diseases extremely increased in the last 2 decades.