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    Histopathologic examination of the effects of cyclosporin a alone and the combined therapy with prednisolone on lung: an experimental study
    (Cambridge University Press, 2003) Altaner, S.; Güven, A.; Coşkun, O.; Barut, C.; Özen, O. A.
    Cyclosporin-A(CsA) is a very potent immunosuppressive agent which is widely used in transplantations and autoimmune diseases. Recent studies suggest an encouraging clinical effect for low-dose, long-term cyclosporin A treatment in different lung diseases[1,2,3,4,5]. Whether administration of CsA might be useful for lowering the dosage of steroids during the treatment of interstitial pneumonia, asthma and lung injuries[6,7,8] is presently a matter of controversy. Several clinical studies reported that CsA might cause pulmonary complications in transplant recipients [9,10]. The aims of this experimental study were: (i) to examine the effects of CsA on lung at morphologic level and to verify the tolerability of long-term, low-dose treatment with this drug; (ii) to analyze if Cremophor-EL(the vehicle in the intravenous form of CyA) is responsible from the changes; (iii) to investigate if combined therapy with Prednisolone has better morphologic results on lung tissue. Forty-eight female Sprague-Dawley rats were divided into four groups: Group I was control. The other three group had daily intraperitoneal injection of 4mg/kg/day CyA for 2,5 months. Group II had oral, Group III had intravenous form of this drug while Group IV had intravenous form of CsA with 1 mg/kg/day prednisolone. Biopsy specimens from lung were embedded in paraffin and the sections were stained with Hematoxylene & Eosin for microscopic examination.