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Yayın Atipik radyolojik tutulumla giden hızlı ilerleyişli nadir bir subakut sklerozan panensefalit olgusu(Maltepe Üniversitesi, 2014) Ayta, Semih; Koç, Begüm Şirin; Çakmak, Miraç Ayşen; Selçuk Duru, H.Nilgün; Elevli, MuratSubakut sklerozan panensefalit (SSPE), kızamık infeksiyonundan yıllar sonra ortaya çıkan, mental kötüleşme, davranış değişiklikleri, miyoklonus ve nörolojik yıkımla seyreden bir hastalıktır. Biz akut konfüzyon ile başlayıp sıradışı radyolojik özellikler gösteren atipik bir SSPE olgusunu sunmayı amaçladık. Öncesinde sağlıklı olan 10 yaşında bir kız çocuğu bir haftadır devam eden baş ağrısı ve sürekli uyku hali ile başvurdu. Dokuz aylıkken kızamık enfeksiyonu öyküsü mevcuttu. Letarjik olup plantar refleks yanıtları bilateral ekstansördü. Sistemik muayene ve rutin biyokimyasal değerlendirmesi normaldi. Beyin manyetik rezonans görüntülemesinde (MRG) beyin sapından serebellar beyaz cevhere uzanan hiperintens lezyonlar görüldü. Rutin beyin omurilik sıvı incelemesi normal olup oligoklonal bantı pozitif, IgG indeksi> 0,7 idi. BOS kızamık antikor titreleri kuvvetli pozitif idi. Elektroensefalografisinde organizasyon bozukluğu ve jeneralize yavaş dalgaları görüldü. Intravenöz (IV) metilprednizolon 5 gün süre ile verildi. Anlamlı bir klinik yanıt alınamadığından IV immunoglobulin tedavisine geçildi. 2.haftada çekilen beyin MRG kontrolünde önceki lezyonlarında artış gözlendi. 4. haftada hasta ani kardiyak arrest nedeniyle kaybedildi. Sonuç: Akut fulminan seyir, beyin sapı ve serebellum tutuluşu SSPE için nadirdir. Baş ağrısı ve akut bilinç değişikliği ile başvuran, kranial görüntülemelerinde atipik bulgular saptanan olgularda subakut sklerozan panensefalit akılda tutulmalıdır.Yayın Atopic disorders are more common in childhood migraine and correlated headache phenotype(WILEY-BLACKWELL, 2014) Ozge, Aynur; Oksuz, Nevra; Ayta, Semih; Uluduz, Derya; Yildirim, Veli; Toros, Fevziye; Tasdelen, BaharBackgroundThe supportive clinical and pathophysiological data about the correlation between migraine and atopic disorders are far from a coincidence. In order to determine and investigate the correlates of atopic disorders in a specific dataset, we performed this retrospective cross-sectional clinical-based study. MethodsThe dataset was composed from three tertiary center web-based databases (). Headache diagnosis and differential diagnosis were made according to the International Classification of Headache Disorders, 2nd version and the Diagnostic Statistical Manual of Mental Disorders, 5th edition. Migraine with aura, migraine without aura, chronic migraine and episodic and chronic tension type headache (TTH) patients were included. All other causes of headache disorders, including comorbid headache disorders like migraine plus TTH or possible causes of headache, were excluded. ResultsThe study included 438 patients with migraine and 357 patients with TTH, whose age and sex distribution were identical. After descriptive statistics accordingly, 80 migraine (18.2%) and 23 TTH (6.4%) patients were found to have specific atopic disorders (P < 0.001). Atopic disorders are more commonly reported in patients with migraine with aura (21.6%) than those with migraine without aura and TTH (P < 0.001). The most common atopic disorders were seasonal rhinitis, conjunctivitis and asthma. There was also a close correlation between TTH with atopic disorders and psychiatric comorbid disorders of the patients. ConclusionsAlthough the International Classification of Headache Disorders, 2nd version, does not specify, atopic disorders should be suspected in all migraine patients and their relatives, not only for accurate diagnosis but also for planning prophylactic medications, such as -blockers.Yayın Auditory Evoked Blink Reflex in Peripheral Facial Paresis(LIPPINCOTT WILLIAMS & WILKINS, 2015) Ayta, Semih; Sohtaoglu, Melis; Uluduz, Derya; Uygunoglu, Ugur; Tutuncu, Melih; Akalin, Mehmet Ali; Kiziltan, Meral E.Purpose:The auditory blink reflex (ABR) is a teleceptive reflex consisting of an early brief muscle contraction of the orbicularis oculi in response to sound stimuli. Constriction of the orbicularis oculi in response to auditory stimulation is accepted as a part of the startle reaction. The blink reflex and ABR might share a final common pathway, consisting of facial nerve nuclei and the facial nerve and may have common premotor neurons.Methods:In this study, the authors evaluated the value of the ABR in patients with peripheral facial palsy (PFP), cross-checking the results with commonly used blink reflex changes.Results:In total, 83 subjects with PFP and 34 age-matched healthy volunteers were included. Auditory blink reflex was elicited in all control subjects and in 36 PFP cases on the paralytic sides (43.3%), whereas it was asymmetric in 30.1% of the patients. Auditory blink reflex positivity was significantly lower in PFP cases with increasing severity. Blink reflex results were largely correlated with ABR positivity.Conclusions:Auditory blink reflex is a useful readily elicited and sensitive test in PFP cases, providing parallel results to blink reflex and being affected by disease severity.Yayın Cognitive Dysfunctions in Epileptic Syndromes(Kare Publ, 2014) Ayta, Semih; Korkmaz, BarisSome children with epilepsy display a low level of intelligence, learning disabilities, attention deficit hyperactivity disorder, mood disorders and anxiety. Besides specific learning disabilities like reading, writing, arithmetics, learning problems may involve other major areas of intellectual functions such as speech and language, attention, memory, fine motor coordination. Even in the presence of common pathology that leads to epilepsy and mental dysfunctions, seizures cause additional cognitive problems. Age at seizure onset, type of seizures and epileptic syndromes are some variables that determine the effect of epilepsy on cognition. As recurrent seizures may have some negative impact on the developing brain, the use of antiepileptic drugs should be considered not only to aim reducing seizures but also to prevent possible seizure-induced cortical dysfunctions. Epilepsy is a disorder requiring a complicated psychological adjustment for the patients and indeed is a disease that affects the whole family. Thus, the management of epilepsy must include educational, psychotherapeutic and behavioral interventions as well as drug treatment.Yayın The COVID-19 from Neurological Overview(TURKISH NEUROLOGICAL SOC, 2020) Acar, Türkan; Demirel, Esra Acıman; Afsar, Nazire; Akçalı, Aylin; Demir, Gülşen Akman; Alagöz, Aybala Neslihan; Mengi, Tuğçe Angin; Arsava, Ethem Murat; Ayta, Semih; Bebek, Nerses; Bilgiç, Başar; Boz, Cavit; Çakar, Arman; Çelebisoy, Nese; Çevik, Mehmet Uygur; Delen, Firuze; Tekçe, Hacer Durmuş; Ekmekçi, Hakan; Elmalı, Ayşe Deniz; Erdinç, Oğuz Osman; Erdoğan, Füsun Ferda; Eren, Fettah; Ergün, Ufuk; Parman, Yeşim Gülşen; Gümüş, Haluk; Algin, Demet İlhan; Karabudak, Rana; Karadaş, Ömer Yıldız; Koç, Emine Rabia; Adapınar, Demet Özbabalık; Özdemir, Atilla Özcan; Öztürk, Şerefnur; Kocaman, Ayşe Sağduyu; Şahin, Sevki; Topcuoğlu, Esen Saka; Sener, Özden; Tezer, F. Irsel; Togrol, Rıfat Erdem; Tokcaer, Ayşe Bora; Topcuoğlu, Mehmet Akif; Tuncer, Neşe; Ali Ulvi, Uluç; Yön, Mehmet İlkerObjective. Comparison of ultrasound (US)-guided erector spinae plane block (ESPB) and serratus anterior plane block (SAPB) in video-assisted thoracic surgery (VATS) patients. The primary outcome was to compare perioperative and postoperative (48 hours) opioid consumption. Methods. A total of 60 patients were randomized into two groups (N =30): an ESPB group and an SAPB group. All the patients received intravenous patient-controlled postoperative analgesia and ibuprofen 400 mg intravenously every eight hours. Visual analog scale (VAS) scores, opioid consumption, and adverse events were recorded. Results. Intraoperative and postoperative opioid consumption at 0-8, 8-16, and 16-24 hours and rescue analgesic use were significantly lower in the ESPB group (P< 0.05). Static/dynamic VAS scores were significantly lower in the ESPB group (P< 0.05). There was no significant difference between static VAS scores at the fourth hour. There were no differences between adverse effects. Block procedure time and one-time puncture success were similar between groups (P > 0.05 each). Conclusion. US-guided ESPB may provide better pain control than SAPB after VATS. Question. Even though there are studies about analgesia management after VATS, clinicians want to perform the technique that is both less invasive and more effective. Findings. This randomized trial showed that US-guided ESPB provides effective analgesia compared with SAPB. Meaning. Performing single-injection ESPB reduces VAS scores and opioid consumption compared with SAPB.Yayın Dikkat Eksikliği Hiperaktivite Bozukluğu Olan Erkek Çocuklarda Bakır ve Serüloplazminin İşitsel Uyarılmış Potansiyeller Üzerinde Olası Etkileri(2016) Mutlu, Caner; Olgun, Abdullah; Özdağ, Mehmet Fatih; Ayta, Semih; Eryılmaz, Gül; Yorbık, ÖzgürAmaç: Bu çalışmanın amaçları, dikkat eksikliği hiperaktivite bozukluğu (DEHB) olan çocuklarda parietal ve frontal bölgelerde P1, N2 ve P3 amplitüd ve latansları ile plazma bakır (Cu) ve serüloplazmin (Cp) düzeyleri arasındaki ilişkiyi incelemekti. Ayrıca, kontrollerdeki bu Cu düzeyleri ve olay-ilişkili potansiyel (OİP) endekslerini karşılaştırmak amaçlandıYayın IFN-gamma response against measles virus peptides in subacute sclerosing panencephalitis patients(ELSEVIER SCIENCE BV, 2014) Yentur, Sibel P.; Adin-cinar, Suzan; Gurses, Candan; Demirbilek, Veysi; Baris, Safa; Ayta, Semih; Kuru, Umit; Yapici, Zuhal; Uysal, Serap; Cokar, Ozlem; Gokyigit, Aysen; Saruhan-direskeneli, Guher…Yayın Possible Effects of Copper and Ceruloplasmin Levels on Auditory Event Potentials in Boys with Attention Deficit Hyperactivity Disorder(AVES, 2016) Yorbik, Ozgur; Mutlu, Caner; Ozdag, Mehmet Fatih; Olgun, Abdullah; Eryilmaz, Gul; Ayta, SemihIntroduction: The aims of the present study were to investigate the relationship between levels of plasma copper (Cu) and ceruloplasmin (Cp) and amplitudes and latencies of P1, N2, and P3 in the parietal and frontal areas of children with attention deficit hyperactivity disorder (ADHD) as well as to compare these Cu levels and event-related potentials (ERPs) indices in controls. Methods: Boys (n=41) with ADHD were divided into two subgroups according to a median split of plasma Cu and Cp levels, separately. ERP indices from the parietal and frontal regions were recorded in children with ADHD and 24 normal boys (control group) using an auditory oddball paradigm. Results: Parietal P3 latency was significantly longer, and parietal P3 amplitude, frontal P3 amplitude, and frontal N2 amplitudes were smaller in children with ADHD than in controls (all p values <0.017). Parietal P1 and frontal P1 latencies were significantly shorter in the higher Cu group than in the lower Cu group (both p values <0.017). Decreased latency of parietal P1 was dependent on plasma levels of Cu (p<0.05). Frontal N2 and parietal N2 amplitudes were significantly lower in the ADHD group with lower Cp levels than in the ADHD group with higher Cp levels (both p values <0.017). Decreased frontal N2 and parietal N2 amplitudes were dependent on plasma levels of Cp (both p values <0.05). Conclusion: Plasma Cu and Cp levels may have an effect on ERPs in ADHD, thus indicating the existence of effects on information processing. Cu levels may have a negative effect on the neuronal encoding of sound, whereas Cp levels may have a positive effect on the processes of cognitive control, conflict monitoring, and stimulus discrimination in children with ADHD.
