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    The dilemma of cesarean myomectomy: Is it safe or not?
    (Ondokuz Mayis Universitesi, 2021) Gürsoy, A.; Atasayan, K.; Doğan, Tekbaş E.; İlter, E.
    To evaluate the safety and effectiveness of myomectomy during cesarean section. The data of fifty-four pregnant who underwent cesarean myomectomy and twenty-six pregnant with uterine leiomyoma who had cesarean section without myomectomy between the years of 2017 and 2020 in our tertiary clinic were examined retrospectively. There was no significant difference in terms of maternal age, weeks of gestation, gravida, parity, use of additional uterotonics, type of leiomyoma, size of leiomyoma, cesarean indications, blood transfusion requirement, postoperative fever, preoperative hemoglobin (g/dl), change in hemoglobin (g/dl), preoperative hematocrit (%), change in hematocrit (%), length of hospital stay between the two groups (p>0.05). While no significant difference was observed according to the location of the leiomyomas between the anterior, fundal and posterior location between the two groups, cervical leiomyomas were significantly higher in the CS group (p<0.05). This study shows that cesarean myomectomy is a safe procedure in selected cases. It also offers the advantage of avoiding a second operation in patients. © 2021 Ondokuz Mayis Universitesi. All rights reserved.
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    Protective effects of glutathione administration on ischemia-reperfusion injury in rat ovaries
    (Ondokuz Mayis Universitesi, 2023) Gürsoy, A.; Ipek, B.O.; Sade, A.G.; Atasayan, K.; Dogan, Tekbaş E.; Sitar, M.E.
    We aimed to examine the biochemical and histopathological potential beneficial effects of glutathione administration on the ovarian ischemia/reperfusion injury (IRI) model. Thirty Wistar Albino female rats were used in this experimental study and were divided into five groups. Group 1 (sham) underwent observational laparotomy. Group 2 (torsion) had their left ovaries torsioned. Group 3 (torsion + detorsion) was detorsioned after torsion. Groups 4 and 5 received the same procedure as group 3. 0,2 ml glutathione was applied to the left ovaries of group 4 (torsion + detorsion + intraovarian glutathione injection) after detorsion. Group 5 (torsion + detorsion + intraperitoneal glutathione injection) was administered 1 ml glutathione intraperitoneally five times. Fifteenth-day blood samples were taken to examine total antioxidant status, total oxidant status, oxidative stress index, anti-mullerian hormone (AMH), and malondialdehyde (MDA) values. Besides, the left ovaries were resected for histopathological examination. Total antioxidant status was significantly higher in the intraperitoneal injection group (p<0.05). The AMH values of the sham and intraovarian groups were similar (p>0.05). MDA value did not differ significantly between the sham, intraovarian, and intraperitoneal injection groups (p>0.05). In histopathological examination, no significant benefit of glutathione application on follicle numbers was shown. The main limitations of our study were the relatively small size of our series, the absence of serial blood measurement, the absence of a group in which intraovarian and intraperitoneal injections were administered together, and the absence of a sham + drug group. Glutathione administration reduces the detrimental effects of ovarian IRI. © 2023 Ondokuz Mayis Universitesi. All rights reserved.
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    Sexual function through decades: association with androgens and cardiometabolic features
    (TAYLOR & FRANCIS LTD, 2020) Yoldemir, T.; Garibova, N.; Atasayan, K.
    Aim: This study aimed to determine the change in sexual function among Turkish women through decades and to define the association between sexual dysfunction and androgens and cardiometabolic features. Materials and methods: A total of 206 postmenopausal women aged 50-69 years and 210 premenopausal women aged 30-49 years who applied to menopause and gynecology clinics at a university-affiliated education and research hospital were included in this prospective study. Groups were constructed according to decades (i.e., 30-39, 40-49, 50-59, and 60-69 years). Sexual function was assessed between the groups, using the Female Sexual Function Index (FSFI). Cardiometabolic features and androgen levels were also compared between the groups. Results: Sexual function determined at each decade by FSFI scores were 27.18, 23.11, 18.40, and 11.35, respectively (fourth, fifth, sixth, and seventh decade). Desire, arousal, and satisfaction domains tended to be lower in the 40s than in the 30s. As time passes after the 30s, the total FSFI score decreased until the late 60s. Serum total testosterone, androstenedione, and dehydroepiandrostenedione sulfate (DHEAS) levels decreased through the decades. There was no correlation between cardiometabolic features, androgens, and FSFI scores. Conclusion: According to our survey, sexual function decreases starting at the age of 30 and continues to drop until the late 60s among postmenopausal women. There was no association between sexual dysfunction and androgen levels in premenopausal women. The serum DHEAS level was associated with sexual dysfunction only among postmenopausal women. There was no association between sexual dysfunction and cardiometabolic features in either premenopausal or postmenopausal women.