DSpace Arşivi :: by Yazar "Aksungar, Fehime Benli" değerine göre listeleniyor

Yazar "Aksungar, Fehime Benli" seçeneğine göre listele

Listeleniyor 1 - 14 / 14

Attenuated lactate response to ischemic exercise in migraine
(INT SCIENTIFIC LITERATURE, INC, 2010) Sahin, Sevki; Cinar, Nilgun; Aksungar, Fehime Benli; Ayalp, Sunay; Karsidag, Sibel
Background: Although the pathogenesis of migraine still remains unclear, certain metabolic studies done on patients with migraine indicate possible deficits in mitochondrial activity. Previously, the forearm ischemic exercise test (FIT) has been used as a screening tool to evaluate mitochondrial dysfunction in metabolic myopathies. Material/Methods: We studied the response of migraine patients to exercise using the modified FIT and compared this to the responses in a healthy group. After baseline venous blood samples were drawn, a sphygmomanometer cuff placed around the upper arm was inflated to 30 mmHg above systolic blood pressure and the subject performed a maximal isometric contraction of the forearm flexors using a hand-grip dynamometer with a 9-contraction: 1-relaxation duty cycle for a total time of 60 seconds. Results: In migraine patients, attenuated lactate response after the FIT in the 1(st), 3(rd) and 5(th) minutes were significantly different when compared to the control group. Conclusions: Our results show that there may be defects in the anaerobic or proximal glycolytic pathways in migraine patients, evident in stressful situations. We also conclude that the FIT may be useful for research on migraine pathophysiology.
Aurasız migrende trombosit serotonin düzeylerinin değerlendirilmesi
(2012) Ayalp, Sunay; Aksungar, Fehime Benli; Şahin, Şevki; Karşıdağ, Sibel
Amaç: Migren ile serotonin düzeyleri arasındaki ilişki net değildir. Daha önceki çalışmalarda migrenlilerde plazma serotonin düzeyleri araştırılmıştır. Ancak, güncel literatürde santral sinir sistemindeki düzeyi yansıtması açısından trombositlerdeki serotonin düzeyinin daha güvenilir sonuçlar vereceği belirtilmektedir. Gereç ve Yöntem: Çalışma Uluslararası Başağrısı Derneğinin ölçütlerine göre tanı almış 30 aurasız migrenli kadın hasta ile yaş ve cinsiyet olarak uyumlu 20 sağlıklı kontrolle gerçekleştirildi. Tüm hasta ve kontrollere Hamilton depresyon ölçeği (HAM-D) uygulandı ve 10 puanın üzerinde alanlar çalışmaya alınmadı. Olgulardan sabah açlık venöz kan örnekleri alındı. Trombositten zengin ve fakir plazma hazırlanarak yüksek performanslı sıvı kromatografisi cihazında değerlendirildi ve trombosit serotonin konsantrasyonu hesaplandı. Bulgular: Çalışmamızda migrenlilerin trombosit serotonin konsantrasyonunu kontrol gurubuna göre istatistiksel olarak anlamlı düzeyde düşük olduğu saptandı. Hasta grubunda ailede migren görülme oranı kontrol grubundan belirgin oranda yüksek bulundu. Migrenlilerin HAM-D puanları kontrol grubundan belirgin düzeyde yüksek bulundu. Atak sayısı ve süresi ile düşük serotonin düzeyleri arasında zayıf bir korelasyon görülse de istatiksel olarak anlamlı bir ilişki saptanmadı. Sonuç: Sonuçlarımız migren patojenezinde düşük serotonin düzeylerine ve migrende kalıtımın rolüne işaret etmektedir. Çalışmaya alınan tüm olgular klinik depresyon puanının altında seçilmiş olmalarına rağmen, migrenlilerde kontrollere göre HAM-D puanları daha yüksek bulunmuştur. Bu durum migrenlilerde düşük serotonin düzeyi ile ilişkili subklinik depresyonun varlığına işaret edebilir. Hem ağrılı hem de ağrısız dönemleri içeren ve serotonin dışında da belirteçleri kapsayan geniş ölçekli çalışmalara ihtiyaç vardır.
Bone turnover and maternal 25(OH) vitamin D3 levels during pregnancy and the postpartum period: should routine vitamin D supplementation be increased in pregnant women?
(ELSEVIER SCIENCE BV, 2011) Haliloglu, Berna; Ilter, Erdin; Aksungar, Fehime Benli; Celik, Aygen; Coksuer, Hakan; Gunduz, Tonguc; Yucel, Erdal; Ozekici, Umit
Objective: To investigate the relationship between 25(OH) vitamin D3 levels and maternal bone turnover during pregnancy and lactation. Study design: Thirty pregnant women and 30 healthy non-pregnant controls were included the study. The pregnant women were examined in the 12th, 25th and 32nd gestational weeks and 6 weeks after delivery. The controls were examined once. Serum concentrations of 25(OH) vitamin D3, parathyroid hormone (PTH), cross-linked C-terminal telopeptide of type I collagen (CTX), calcium, and phosphate were measured. Results: In the 32nd week and the postpartum period, 25(OH) vitamin D3 deficiency rates were 13.3% and 333%, respectively. Serum 25(OH) vitamin 03 levels were below the detection limit in 10% and 33%, respectively, of the same subjects. In the control group, rates of 25(OH) vitamin D3 deficiency and "below detection limit" were 30% and 23%, respectively. While 25(OH) vitamin 03 and CTX levels were not correlated to each other in the first trimester, a negative correlation was found in the 2nd and 3rd trimesters and the postpartum period between 25(OH) vitamin 03 and CTX levels (r = -0.472, p = 0.048; r = -0.893, p < 0.0001, r = -0.881, p < 0.001, respectively). No correlation between 25(OH) vitamin D3 and CTX levels was found in controls. Conclusion: We consider that 25(OH) vitamin D3 supplementation of women could both decrease maternal bone resorption and lead to enhanced bone mass in offspring during later life. Since women are prone to 25(OH) vitamin D3 insufficiency, we suggest higher doses of 25(OH) vitamin D3 should be given to pregnant subjects. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
Bronchial hyperreactivity and airway wall thickening in obstructive sleep apnea patients
(SPRINGER HEIDELBERG, 2011) Sariman, Nesrin; Levent, Ender; Cubuk, Rahmi; Yurtlu, Sirin; Aksungar, Fehime Benli
Hypoxia/reoxygenation episodes in obstructive sleep apnea (OSA) results in the alteration of the oxidative balance, leading to the development of inflammation. Airway wall thickening and inflammatory changes are suggested as a primary cause of the airway hyperresponsiveness in asthmatics. Bronchial hyperreactivity (BH) may also occur in patients with OSA. We investigated the presence of BH and airway wall thickness in OSA and correlations with inflammatory markers. Sixteen OSA patients and ten controls without allergic diseases were prospectively studied. Plasma pro-B-type natriuretic peptide (pro-BNP), fibrinogen, D-dimer, alpha 1-antitrypsin, and high-sensitive C-reactive protein levels were measured. Airway wall thickness was evaluated with high-resolution CT, and BH was assessed by giving each subject a methacholine challenge test. In OSA patients, bronchial wall thickness, fibrinogen, D-dimer, alpha 1-antitrypsin, high sensitive C-reactive protein, and pro-BNP levels were significantly greater than those in control subjects. Among the 16 patients, three had BH on methacholine challenge. Bronchial wall thickness(mm) was positively correlated with apnea-hypopnea index (AHI: number of apneas + hypopneas/hour of sleep), BMI, respiratory arousal index, nocturnal oxygen desaturation (NOD) duration (time in minutes with a nocturnal arterial oxygen saturation of < 90% during sleep), and alpha 1-antitrypsin levels. NOD duration also correlated with pro-BNP and fibrinogen levels. In OSA patients, walls of central airways were thicker than normal subjects. BH may have occurred in OSA patients. NOD duration correlated with inflammatory parameters and oxygen desaturation index 3% had an effect on the thickness of bronchial walls. But overall, AHI was found to be the only independent predictor of bronchial wall thickness.
Comparison of Melatonin and Ozone in the Prevention of Reperfusion Injury Following Unilateral Testicular Torsion in Rats
(ELSEVIER SCIENCE INC, 2012) Ekici, Sinan; Ekici, A. Isin Dogan; Ozturk, Guler; Aksungar, Fehime Benli; Sinanoglu, Orhun; Turan, Guven; Luleci, Nurettin
OBJECTIVE To compare the efficacy of ozone with melatonin, shown as the most powerful antioxidant in attenuation of testicular ischemia/reperfusion injury, in an experimental rat model of testicular torsion/detorsion. METHODS Twenty-four male Wistar rats were divided into 4 groups: sham-operated, torsion/detorsion, torsion/detorsion plus melatonin, and torsion/detorsion plus ozone. Melatonin (10 mg/kg) and ozone (4 mg/kg) were intraperitoneally injected daily beginning 15 minutes before detorsion for the following 7 days. At the seventh day, blood and tissue samples were obtained. Johnsen score, malondialdehyde, inhibin B, glutathione plasma total sulfhydryl group (RSH) levels, and total nitric oxide were studied. RESULTS Torsion/detorsion caused increase in tissue malondialdehyde and total nitric oxide along with a decrease in Johnsen score, tissue and plasma inhibin B, RSH, and glutathione levels. Melatonin prevented the rise in malondialdehyde and total nitric oxide levels and improved Johnsen score, tissue and plasma inhibin B, and tissue glutathione levels, along with a decrease in plasma RSH level. Ozone showed similar results except for the total nitric oxide level. Concomitantly, in contralateral testis, melatonin and ozone induced similar changes for Johnsen score, malondialdehyde, and inhibin B (not significant) and in glutathione (significant). Melatonin decreased the total nitric oxide level in both testes and ozone increased the same parameter. CONCLUSION On different pathways, ozone was comparable with melatonin in the amelioration of ischemia/reperfusion injury. Protective effects of ozone were associated with nitrous oxide. The potential for ozone as a treatment for torsion/detorsion therefore deserves to be further elucidated. UROLOGY 80: 899-906, 2012. (C) 2012 Elsevier Inc.
The Effect of Vitamin C on Ischemia Reperfusion Injury Because of Prolonged Tourniquet Application With Reperfusion Intervals
(LIPPINCOTT WILLIAMS & WILKINS, 2009) Ulug, Burcak Tumerdem; Aksungar, Fehime Benli; Mete, Ozgur; Tekeli, Fatma; Mutlu, Nilgun; Calik, Burcu
We examined the effect of vitamin Con muscle injury distal to the tourniquet which was applied for 4 hours with 10- and 20-minute reperfusion intervals after 2 hours of tourniquet. Sixty-four Sprague-Dawley rats were allocated to 4 randomized groups. After 2 hours tourniquet, 10- and 20-minutes of reperfusion were allowed to half of each group respectively. Afterward an additional 2 hours compression was applied. Except the control group the animals received vitamin C intravenously, before the first tourniquet in Group 1, at the reperfusion interval in Group 11, and at both times in Group III. Malondialdehyde levels were measured in blood and the tibialis anterior muscle. The muscle was histopathologically examined. The data was evaluated statistically. The effects of timing and the dose of vitamin C on ischemia reperfusion injury remain controversial and there was no statistical difference between 10- and 20-minute reperfusion intervals. But the blood malondialdehyde levels showed that vitamin C has a positive effect on the muscle injury caused by ischemia-reperfusion.
Homocysteine Levels and Echocardiographic Findings in Obstructive Sleep Apnea Syndrome
(KARGER, 2010) Sariman, Nesrin; Levent, Ender; Aksungar, Fehime Benli; Soylu, Akin Cem; Bektas, Osman
Background: The obstructive sleep apnea syndrome (OSAS) is characterized by repeated upper airway obstruction during sleep together with decreases in oxygen saturation leading to a series of pathological events, primarily in the cardiovascular system. Elevated plasma homocysteine levels have recently been considered as an independent risk factor for vascular disease, and increased levels are attributed to cardiovascular diseases. Objectives: We aimed to investigate the possible relationship between homocysteine levels and echocardiographic findings in OSAS patients at different stages of disease. Methods: Thirty-eight patients (23 males and 15 females) with polysomnographically verified OSAS (mean age, 49 +/- 12 years, range 27-74) and a mean body mass index of 31.27 +/- 5.24 kg/m(2) (range 22.60-47.90) were prospectively studied. Plasma levels of homocysteine, cholesterols, triglycerides, vitamin B(12) and high-sensitive C-reactive protein (hsCRP), as well as echocardiographic and lung function parameters were assessed. Results: Homocysteine levels were elevated in all OSAS groups and were statistically significantly different between the mild and moderate/severe groups. Significant differences were present between the variables nocturnal oxygen desaturation (NOD), respiratory arousal and light sleep among the mild and moderate/severe groups. We found a significant positive correlation between homocysteine levels and NOD duration, and hsCRP levels were positively correlated with the apnea-hypopnea index and NOD duration. Conclusions: In all OSAS groups, homocysteine levels were elevated regardless of the presence of cardiac dysfunction. Echocardiographic abnormalities were primarily left-ventricular (LV) hypertrophy and LV diastolic dysfunction and could be observed in all OSAS severity groups. Copyright (C) 2009 S. Karger AG, Basel
Melatonin with 1,25-Dihydroxyvitamin D3 Protects against Apoptotic Ischemia-Reperfusion Injury in the Rat Kidney
(INFORMA HEALTHCARE, 2012) Sinanoglu, Orhun; Sezgin, Gulbuz; Ozturk, Guler; Tuncdemir, Matem; Guney, Sevin; Aksungar, Fehime Benli; Yener, Nese
This study was designed to evaluate the preventive role of melatonin (Mel) and 1,25-dihydroxyvitamin D3 (VD3) in biochemical and apoptotic events leading to tissue injury and renal dysfunction after ischemia-reperfusion (I/R). Thirty male Wistar rats were divided into five groups: sham-operated, I/R, Mel + I/R, VD3 + I/R, and Mel + VD3 + I/R. The rats were intraperitoneally administered with Mel (10 mg/kg), VD3 (0.5 mu g/kg), or Mel (10 mg/kg) plus VD3 (0.5 mu g/kg) each day at 1 week prior to ischemia. Right nephrectomy was initially performed and left renal I/R injury was induced by 45 min of bilateral renal ischemia followed by 45 min of reperfusion. After reperfusion, kidneys and blood were obtained for histopathologic and biochemical evaluation. Mel and VD3 had an ameliorative effect on biochemical parameters such as serum creatinine, blood urea nitrogen, alanine aminotransferase, aspartate aminotransferase, and apoptosis (caspase-3 and terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling staining) in the kidneys against renal I/R injury in rats. Additionally, VD3 combined with Mel significantly reduced apoptotic and histological alterations when compared with Mel or VD3 alone. This preventive effect on renal tubular apoptosis was remarkable when Mel was combined with VD3.
Negative correlation between D-dimer and homocysteine levels during pregnancy and the postpartum period a prospective study
(ELSEVIER SCIENCE BV, 2010) Haliloglu, Berna; Aksungar, Fehime Benli; Celik, Aygen; Ilter, Erdin; Coksuer, Hakan; Ozekici, Umit
Objective There have been conflicting data about the role of increased levels of homocysteine (Hcy) on haemostatic system We aim to investigate prospectively the relation between serum Hcy levels and changes in haemostatic system in pregnancy and postpartum period Study design Sixty-eight healthy pregnant women were included in the study Blood samples were obtained in the 11th gestational week 25th gestational week 32nd gestational week and postpartum 4th week The haemoglobin levels white blood cell count (WBC) platelet count activated partial thromboplastin time (aPTI-) prothrombin time (PT) fibrinogen D-dimer Hcy vitamin B12 and folate levels were measured Results Serum Hcy levels were negatively correlated with D-dimer levels (r = -0 57 p < 0 0001) The highest levels of D-dimer (1046 62 +/- 322 01 ng/ml) were achieved in the third trimester and the lowest levels of serum Hcy (4 45 +/- 123 mmol/1) were detected in the same trimester In postpartum fourth week D dimer levels were decreased to normal levels (238 27 +/- 198 59 ng/ml) while the serum Hcy levels were reached to the highest levels (7 99 +/- 1 36 mmol/1) Conclusion The negative correlation between Hcy and D-dimer levels may be a compensatory mechanism to maintain the normal haemostatic balance in pregnancy Hence possible advantage of low Hcy levels in pregnancy may be to prevent undesired thrombosis (C) 2010 Elsevier Ireland Ltd All rights reserved
Paranazal sinüs yerleşimli bir mantar topu: olgu sunumu
(2007) Şahin, Ethem; Aksungar, Fehime Benli; Özakkaş, Fatma; Topkaya, Aynur E.; Koca, Öncel
Mantar topu, paranazal sinüslerin mantar infeksiyonları arasında oldukça ender görülen bir hastalıktır. Olgumuz, öncesinde herhangi bir hazırlayıcı neden olmaksızın gelişen, maksiller sinüs yerleşimli mantar topu tanısı alması nedeniyle sunulmuştur.50 yaşındaki kadın hasta, son 2 aydır devam eden, sol tarafta burun tıkanıklığı, baş ağrısı ve post-nazal akıntı şikayetleriyle Kulak Burun Boğaz polikliniğine başvurmuştur. Çekilen paranazal sinüs bilgisayarlı tomografisinde sol maksiller sinüsü dolduran bir kitle saptanmıştır. Hastaya genel anestezi altında sol fonksiyonel endoskopik sinüs cerrahisi uygulanarak kitlenin tamamı boşaltılmıştır. Örneğin mikrobiyolojik incelemesi sırasında Aspergillus türünü düşündüren tipik morfolojik yapılar izlenmiştir.Öncesinde ortodontik girişim, kronik hastalık veya bağışık sistemi baskılayan herhangi bir ilaç kullanımı olmasada, özellikle orta yaş ve üzerindeki kadın hastalarda, sinüslerdeki kitlenin ayırıcı tanısında küf mantarları da düşünülerek mikolojik inceleme istenmelidir.
The Protective Effects of Spirulina in Cyclophosphamide Induced Nephrotoxicity and Urotoxicity in Rats
(ELSEVIER SCIENCE INC, 2012) Sinanoglu, Orhun; Yener, Arzu Nese; Ekici, Sinan; Midi, Ahmet; Aksungar, Fehime Benli
OBJECTIVE To evaluate the role of Spirulina, a blue-green algae with antioxidant properties in the protection of cyclophosphamide-induced nephrotoxicity and hemorrhagic cystitis in rats. METHODS The control group (C) was sacrificed 24 hours after being given a single dose of saline intraperitoneally (150 mg/kg) on the seventh day of the experiment. The rats in the second group (CP) were sacrificed 24 hours after being given a single dose of cyclophosphamide, intraperitoneally (150 mg/kg) on the seventh day of the experiment. Spirulina was administered to the third group (SP + CP) orally (1000 mg/kg bw/day) for 7 days and a single dose of cyclophosphamide was injected intraperitoneally (150 mg/kg) on the seventh day of the experiment. At the eighth day of the experiment, malondialdehyde, superoxide dismutase, and catalase levels in renal and urinary bladder tissues were measured. Histomorphology in urinary bladder, apoptosis by caspase 3 immunostaining, and TUNEL assay in kidney were also evaluated. RESULTS Tissue levels of malondialdehyde in the SP + CP group were significantly lower versus CP group (P < .05). Tissue levels of superoxide dismutase and catalase in the SP + CP group were significantly higher vs the CP group (P < .05). The histomorphologic alteration in urinary bladder in the SP + CP group was significantly lower vs that in the CP group. In the kidney, apoptosis in the SP + CP group as shown with TUNEL assay and immunohistochemistry was significantly lower vs that in the CP group (P < .05). CONCLUSION Pretreatment with Spirulina protects the rats from cyclophosphamide-induced nephro-urotoxicity via its antioxidant and anti-apoptotic properties. UROLOGY 80: 1392.e1-1392.e6, 2012. (C) 2012 Elsevier Inc.
Relationship between bone mineral density, bone turnover markers and homocysteine, folate and vitamin B12 levels in postmenopausal women
(SPRINGER HEIDELBERG, 2010) Haliloglu, Berna; Aksungar, Fehime Benli; Ilter, Erdin; Peker, Hakan; Akin, Figen Temelli; Ozekici, Umit
We aimed to investigate whether levels of homocysteine (Hcy), folate, and vitamin B12 are related to bone turnover markers and bone mineral density (BMD) in postmenopausal women. One hundred and twenty postmenopausal women were divided into three groups: osteoporotic, osteopenic and normal, according to the BMD measurements. The age, weight, body mass index (BMI), years since menopause (YSM), gravidity, parity, bone turnover markers [type I collagen C-telopeptides (CTx) and bone-specific alkaline phosphatase (BAP)], serum Hcy, parathyroid hormone (PTH), vitamin B12, folate, calcium and magnesium levels were compared with each other. Twenty-five women had osteoporotic, 42 women had osteopenic, and 53 had normal BMD values. After adjusting for confounding factors, serum Hcy levels were significantly higher in osteoporotic women [adj OR = 38.95 (1.474-1029.88) p = 0.02]. The age, YSM, PTH, CTx and BAP levels were related to serum Hcy in all women (beta = 0.523, p = 0.0001; beta = 0.446, p = 0.001; beta = 0.295, p = 0.005; beta = 0.239, p = 0.026; beta = 0.451, p = 0.001, respectively). Our data showed that vitamin B12, folate and Hcy levels were not related with BMD in postmenopausal women. We think that one of the underlying mechanisms of increased Hcy levels and osteoporosis may be a mechanistic link which cannot detected by BMD or biochemical markers.
Relationship between bone mineral density, bone turnover markers and homocysteine, folate and vitamin B12 levels in postmenopausal women (vol 281, pg 663, 2010)
(Springer Heidelberg, 2010) Haliloglu, Berna; Aksungar, Fehime Benli; Ilter, Erdin; Peker, Hakan; Akin, Figen Temelli; Mutlu, Nilgün; Özekici, Umit
[Abstract Not Available]
Voice and Speech Changes in Various Phases of Menstrual Cycle
(MOSBY-ELSEVIER, 2013) Celik, Oner; Celik, Aygen; Atespare, Altay; Boyaci, Zerrin; Celebi, Saban; Gunduz, Tonguc; Aksungar, Fehime Benli; Yelken, KursAt
Background. The reproductive system in females undergoes a regular cyclic change known as the menstrual cycle. Laryngeal changes are evident and fluctuate systematically during the reproductive years with the menstrual cycle. The impact of estrogens in concert with progesterone produces the characteristics of the female voice, with a fundamental frequency (F-0) higher than that of male. Objective. To characterize changes in voice and speech in adolescent females in different phases of the menstrual cycle-during menstruation, after menstruation, mid-menstrual cycle, and premenstruation. Materials and Methods. Sixteen adult females who were nonusers of oral contraceptives participated in a cross-sectional study of menstrual cycle influences on voicing and speaking tasks. Acoustic analysis (F-0, intensity, perturbation measurements [jitter and shimmer], and harmonic-to-noise ratio), maximum phonation time (MPT), s/z ratio, and perceptual assessments (grade [G], roughness [R], breathiness [B], asthenia [A], and strain [S] [GRBAS] and Voice Handicap Index-10 [VHI-10]) scales were performed during all phases. Results. None of the acoustic analysis parameters and MPT and s/z ratio measurements revealed statistically significant difference (P > 0.05). Perceptual voice assessment scales either clinician based or patients self-evaluated showed significant differences among phases (P < 0.05). Conclusions. The objective voice analysis methods, such as acoustic analysis, MPT, and s/z ratio, determined no difference; however, the subjective voice analysis methods, such as clinician-based perceptual assessment (GRBAS) and patients self-evaluation (VHI-10) scales, demonstrated significant changes during different phases of menstrual cycle.

Yazar "Aksungar, Fehime Benli" seçeneğine göre listele

Sayfa Başına Sonuç

Sıralama seçenekleri